To effectively control the critical thickness of a polydimethylsiloxane (PDMS) film and enhance the sensitivity characteristics of the fiber pressure sensor, we propose a new method to optimize the thickness of the PDMS film in a fiber tube. It is characterized by analyzing the relationship between the diffusion rate of the PDMS and its viscosity, and using an oven to solidify the PDMS to a certain extent to accurately control the diffusion rate and diffusion length of the PDMS in the fiber tube. We also used multiple transfer methods to control the volume of the PDMS in the fiber tube to minimize the thickness of the formed PDMS film. Fabry-Perot interference occurs when the surface of the PDMS film layer filled into the fiber tube and the adjacent single mode fiber/fiber tube form a joint surface. This method forms a new fiber-optic Fabry-Perot pressure sensor that is very sensitive to external pressure parameters. The experimental results show that the optimized film thickness will be reduced to an order of 20 μm. Correspondingly, the fiber-optic pressure sensor has a sensitivity of up to 100 pm/kPa, which is about 100 times that reported in the literature. The structure also has better resistance to temperature interference. To our knowledge, this is the first in-depth study of the effects of the PDMS viscosity coefficient, diffusion rate, and fiber pressure sensitivity in fiber. The film thickness optimization method has some advantages, including a low cost, good controllability, and good application value in high sensitivity pressure and sound wave detection.