Wurtzite-structured III-group nitrides, like GaN, InN, AlN, and their alloys, present both piezoelectric and semiconducting properties under straining owing to the polarization of ions in a crystal with non-central symmetry. The piezoelectric polarization charges are created at the interface when a strain is applied. As a result, a piezoelectric potential (piezopotential) is produced, which is used as a "gate" to tune/control the charge transport behavior across a metal/semiconductor interface or a p-n junction. This is called as piezotronic effect. A series of piezotronic devices and applications have been developed, such as piezotronic nanogenerators (NGs), piezotronic transistors, piezotronic logic devices, piezotronic electromechanical memories, piezotronic enhanced biochemical, and gas sensors and so on. With the flourished development of piezotronic effect, the piezo-phototronic effect, as the threeway coupling of piezoelectric polarization, semiconductor properties, and optical excitation, utilizes the piezopotential to modulate the energy band profile and control the carrier generation, transportation, separation, and/or recombination for improving performances of optoelectronic devices. This paper intends to provide an overview of the rapid progress in the emerging fields of piezotronics and piezo-phototronics, covering from the fundamental principles to devices and applications. This study will provide important insight into the potential applications of GaN based electronic/optoelectronic devices in sensing, active flexible/stretchable electronics/optoelectronics, energy harvesting, human-machine interfacing, biomedical diagnosis/therapy, and prosthetics. Figure 2. Piezopotential in wurtzite crystal. a) Atomic model of the wurtzite Àstructured ZnO. b) The piezopotential distributed along a ZnO NW under axial strain calculated by numerical methods. The growth direction of the NW is along the c-axis. (Reproduced with permission. [27]