Pig and Mouse Models of Hyperlipidemia and Atherosclerosis

Getz, Godfrey S.; Reardon, Catherine A.

doi:10.1007/978-1-0716-1924-7_24

Cited by 5 publications

(2 citation statements)

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“…The above brief review of atherogenic lesion formation reveals an extremely complex set of interactions, with most of these potential interactions illuminated by studies in animals, particularly mice. Aside from mice, pigs, especially minipigs, are valuable models for atherosclerosis studies [ 11 ]. Inducing atherosclerosis in mice requires significantly increasing the levels of apoB-containing lipoproteins.…”

Section: Murine Models Of Atherosclerosismentioning

confidence: 99%

“…Since it is difficult to undertake detailed experimentation in humans, investigators have turned to experimental animals, large and small, to approach the mechanisms that account for the development of lesions at atherosclerosis-susceptible regions of the arterial tree [ 10 , 11 ]. Murine models are currently favored for the experimental study of atherogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Insights from Murine Studies on the Site Specificity of Atherosclerosis

Getz,

Reardon

2024

IJMS

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Atherosclerosis is an inflammatory reaction that develops at specific regions within the artery wall and at specific sites of the arterial tree over a varying time frame in response to a variety of risk factors. The mechanisms that account for the interaction of systemic factors and atherosclerosis-susceptible regions of the arterial tree to mediate this site-specific development of atherosclerosis are not clear. The dynamics of blood flow has a major influence on where in the arterial tree atherosclerosis develops, priming the site for interactions with atherosclerotic risk factors and inducing cellular and molecular participants in atherogenesis. But how this accounts for lesion development at various locations along the vascular tree across differing time frames still requires additional study. Currently, murine models are favored for the experimental study of atherogenesis and provide the most insight into the mechanisms that may contribute to the development of atherosclerosis. Based largely on these studies, in this review, we discuss the role of hemodynamic shear stress, SR-B1, and other factors that may contribute to the site-specific development of atherosclerosis.

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Section: Murine Models Of Atherosclerosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%