Pig Coat Color Manipulation by MC1R Gene Editing

Zhong, Haiwen; Zhang, Jian; Tan, Cheng; Shi, Junsong; Yang, Jie; Cai, Guangyan; Wu, Zhenfang; Yang, Huaqiang

doi:10.3390/ijms231810356

Cited by 7 publications

(3 citation statements)

References 24 publications

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“…The active form of MC1R promotes eumelanin synthesis, producing a uniformly black coat colour. At the same time, inactive MC1R is associated with phaeomelanin production, resulting in a red or yellow coat colour [108]. In pigs, four MC1R variants corresponding to five different E alleles have been associated with coat-colour phenotypes ranging from recessive red to dominant black: MC1R*-E+, and MC1R*1-E+ for wild type, MC1R*2-E D1 , MC1R*7-E D1 , and MC1R*3-E D2 for dominant black, and MC1R*6-E P for black spotting and recessive red MC1R*4-e. [109].…”

Section: Specific Genes and Genetic Markers Identified In Belted Pig ...mentioning

confidence: 99%

Genetic and Phenotypic Characteristics of Belted Pig Breeds: A Review

Giovannini,

Strillacci,

Bagnato

et al. 2023

Animals

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Belted pig breeds have unique, distinguishing phenotypic characteristics. This review summarises the current knowledge on pig breeds displaying a belted coat pattern. Belts of different widths and positions around the animal’s trunk characterise specific pig breeds from all around the world. All the breeds included in the present paper have been searched through the FAO domestic animal diversity information system (DAD-IS), Every country was checked to identify all breeds described as having black or red piebald coat pattern variations. Advances in genomic technologies have made it possible to identify the specific genes and genetic markers associated with the belted phenotype and explore the genetic relationships between different local breeds. Thus, the origin, history, and production traits of these breeds, together with all the genomic information related to the mechanism of skin pigmentation, are discussed. By increasing our understanding of these breeds, we can appreciate the richness of our biological and cultural heritage and work to preserve the biodiversity of the world’s animals.

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Section: Specific Genes and Genetic Markers Identified In Belted Pig ...mentioning

confidence: 99%

Genetic and Phenotypic Characteristics of Belted Pig Breeds: A Review

Giovannini,

Strillacci,

Bagnato

et al. 2023

Animals

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“…Coat color is also a significant factor in breed selection. Researchers have used gene editing techniques to develop Duroc pigs with black coats, aiming to create superior breeds with high growth rates, high meat production, and coat color preferences of consumers [ 19 ]. Understanding the genetic mechanisms behind coat color diversity is crucial for assessing breeding germplasm resources.…”

Section: Introductionmentioning

confidence: 99%

Coloration in Equine: Overview of Candidate Genes Associated with Coat Color Phenotypes

Liu,

Peng,

Zhang

et al. 2024

Animals

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Variation in coat color among equids has attracted significant interest in genetics and breeding research. The range of colors is primarily determined by the type, concentration, and distribution of melanin pigments, with the balance between eumelanin and pheomelanin influenced by numerous genetic factors. Advances in genomic and sequencing technologies have enabled the identification of several candidate genes that influence coat color, thereby clarifying the genetic basis of these diverse phenotypes. In this review, we concisely categorize coat coloration in horses and donkeys, focusing on the biosynthesis and types of melanin involved in pigmentation. Moreover, we highlight the regulatory roles of some key candidate genes, such as MC1R, TYR, MITF, ASIP, and KIT, in coat color variation. Moreover, the review explores how coat color relates to selective breeding and specific equine diseases, offering valuable insights for developing breeding strategies that enhance both the esthetic and health aspects of equine species.

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“…Several important genes affecting pig coat color phenotypes have been identified to date, including mast/ stem-cell growth factor receptor (KIT), Melanocyte Inducing Transcription Factor (MITF), antagonist Agouti Signaling Protein (ASIP), DCT, Tyrosinase-related Protein 1 (TYRP1) (Du et al 2022). Melanocortin 1 Receptor (MC1R) gene determines dominant black, black-spotted, and red coat colors in Western and Chinese pigs (Zhong et al 2022). The skin and hair pigmentation in mammals results from cellular activities and cooperation between two cell types, melanocytes producing melanin and keratinocytes distributing melanin throughout the skin (Le et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Genetic variation within the coat color gene of Melanocortin 1 Receptor (MC1R) in Mong Cai pigs of Vietnam

THUY

LONG

et al. 2023

Biodiversitas

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Abstract. Thuy CTT, Ha CD, Long TD, Hai TV, Long ST, Chi TT, Quyen TTH, Yen VH, Khanh NTM, Trung NQ, Trung NT. 2023. Genetic variation within the coat color gene of Melanocortin 1Receptor (MC1R) in Mong Cai pigs of Vietnam. Biodiversitas 24: 1735-1741. Pig (Sus scrofa) is considered one of the major domesticated animals in Vietnam. Various indigenous pig varieties have been successfully developed as the Vietnamese's main daily meat source. However, little information has been reported about the conservation of these indigenous pig varieties. In this study,the Mong Cai, a prized domestic pig breed in Vietnam, is well-characterized by a black saddle on the hips extending to the lower abdomen. As a result of the introduction of exotic breeds and crossbreeding, Mong Cai pigs exhibited various phenotypic characteristics and coat colors. We constructed a database of Melanocortin 1Receptor(MC1R) coding sequences, including the MC1Rsequences of 26 Mong Cai and 20 other pig breeds from Europe and Asia. Subsequently, 12 haplotypes were determined using 18 mutations in 46 individuals. The phylogenetic tree result indicated that the Mong Cai population was distributed into two distinct haplotypes. Moreover, Mong Cai pigs could belong to the Asian clade; however, six Mong Cai individuals formed a distinct cluster. These six individuals carried the nt729G gene, which is prevalent in European pigs. In addition, our study could provide a solid foundation for further investigation of the evolution of indigenous pig varieties in Vietnam.

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Pig Coat Color Manipulation by MC1R Gene Editing

Cited by 7 publications

References 24 publications

Genetic and Phenotypic Characteristics of Belted Pig Breeds: A Review

Genetic and Phenotypic Characteristics of Belted Pig Breeds: A Review

Coloration in Equine: Overview of Candidate Genes Associated with Coat Color Phenotypes

Genetic variation within the coat color gene of Melanocortin 1 Receptor (MC1R) in Mong Cai pigs of Vietnam

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