Pigeon-Associated Strains of
            <i>Salmonella enterica</i>
            Serovar Typhimurium Phage Type DT2 Have Genomic Rearrangements at rRNA Operons

Helm, R. Allen; Porwollik, Steffen; Stanley, April E.; Maloy, Stanley; McClelland, Michael; Rabsch, Wolfgang; Eisenstark, A.

doi:10.1128/iai.72.12.7338-7341.2004

Cited by 16 publications

(12 citation statements)

References 18 publications

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“…This might explain why major genomic rearrangements owing to homologous recombination between the rrn operons are a characteristic feature of the chromosomes of S. Typhi isolates Sanderson 1995, 1996;Kothapalli et al 2005;Matthews et al 2010). Similar genome rearrangements are also found in other host-restricted lineages within the genus Salmonella, including S. Paratyphi C, S. Gallinarum, and S. Typhimurium phage type DT2 (Liu and Sanderson 1998;Helm et al 2004;Wu et al 2005;Liu et al 2007). Thus, rearrangements are a genomic signature of host-restricted members of the genus Salmonella that rely on chronic persistence in the host for transmission.…”

Section: Genomic Rearrangementsmentioning

confidence: 75%

Host Specificity of Bacterial Pathogens

Bäumler

Fang

2013

Cold Spring Harbor Perspectives in Medicine

173

134

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Section: Genomic Rearrangementsmentioning

confidence: 75%

Host Specificity of Bacterial Pathogens

Bäumler

Fang

2013

Cold Spring Harbor Perspectives in Medicine

173

134

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“…In a recent study of pigeon-associated serovar Typhimurium DT2 strains, Helm et al also detected genomic rearrangements in the rrnD-and rrnE-flanked region (9). Whether rearrangements in this region would relate to bird adaptation of the Salmonella pathogens remains to be investigated.…”

Section: Discussionmentioning

confidence: 99%

The Genome of Salmonella enterica Serovar Gallinarum: Distinct Insertions/Deletions and Rare Rearrangements

Wu¹,

Liu

Liu³

et al. 2005

J Bacteriol

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Salmonella enterica serovar Gallinarum is a fowl-adapted pathogen, causing typhoid fever in chickens. It has the same antigenic formula (1,9,12:-:-) as S. enterica serovar Pullorum, which is also adapted to fowl but causes pullorum disease (diarrhea). The close relatedness but distinct pathogeneses make this pair of fowl pathogens good models for studies of bacterial genomic evolution and the way these organisms acquired pathogenicity. To locate and characterize the genomic differences between serovar Gallinarum and other salmonellae, we constructed a physical map of serovar Gallinarum strain SARB21 by using I-CeuI, XbaI, and AvrII with pulsed-field gel electrophoresis techniques. In the 4,740-kb genome, we located two insertions and six deletions relative to the genome of S. enterica serovar Typhimurium LT2, which we used as a reference Salmonella genome. Four of the genomic regions with reduced lengths corresponded to the four prophages in the genome of serovar Typhimurium LT2, and the others contained several smaller deletions relative to serovar Typhimurium LT2, including regions containing srfJ, std, and stj and gene clusters encoding a type I restriction system in serovar Typhimurium LT2. The map also revealed some rare rearrangements, including two inversions and several translocations. Further characterization of these insertions, deletions, and rearrangements will provide new insights into the molecular basis for the specific host-pathogen interactions and mechanisms of genomic evolution to create a new pathogen.

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“…Although the majority of S. enterica serovar Typhimurium strains affect multiple hosts (Helm et al 2004), there are no reports regarding the existence of serovar Typhimurium phage type DT2 in dogs.…”

Section: Discussionmentioning

confidence: 99%

“…However, some serotype Typhimurium variants have an only very narrow host range whereas other species may transmit infections to multiple hosts (Baumler et al 1998;Rabsch et al 2002). Although the majority of S. Typhimurium strains affect several animal species, the phage types (DT) 2 and 99 of Salmonella Typhimurium have been associated with systemic diseases particularly in pigeons (Pasmans et al 2003;Helm et al 2004). Serotype Typhimurium can be differentiated into numerous distinct variants by phage typing and other epidemiological typing methods (Pang et al 2013).…”

mentioning

confidence: 99%

An abdominal cavity abscess associated with Salmonella enterica serovar Typhimurium phage type DT2 in a dog: a case report

Bayram¹,

Aydın²

2016

Vet. Med. - Czech

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Most Salmonella enterica serovar Typhimurium strains are capable of infecting multiple hosts. In this report, an abdominal cavity abscess associated with the Salmonella enterica serovar Typhimurium phage type DT2 is described in a dog. A dead male dog was admitted to the Department of Pathology at the Faculty of Veterinary Medicine at Erciyes University for necropsy. Anorexia, weight loss and lethargy were the clinical symptoms that were reported by the owner of the dog. The diagnosis was made by histopathological and bacteriological examinations of the lungs, spleen, liver and heart. In addition, the content of the abdominal cavity mass was evaluated in bacteriological analysis. The serotyping, phage typing and antibiotic susceptibility of the isolated bacteria were performed at the Danish Institute for Food and Veterinary Research. To the best of the authors' knowledge, this is the first study reporting an abscess associated with S. enterica serovar Typhimurium phage type DT2 in a dog.

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Pigeon-Associated Strains of Salmonella enterica Serovar Typhimurium Phage Type DT2 Have Genomic Rearrangements at rRNA Operons

Cited by 16 publications

References 18 publications

Host Specificity of Bacterial Pathogens

Host Specificity of Bacterial Pathogens

The Genome of Salmonella enterica Serovar Gallinarum: Distinct Insertions/Deletions and Rare Rearrangements

An abdominal cavity abscess associated with Salmonella enterica serovar Typhimurium phage type DT2 in a dog: a case report

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