Pigment Epithelium-Derived Factor as a Possible Treatment Agent for Choroidal Neovascularization

Xi, Lei

doi:10.1155/2020/8941057

Cited by 21 publications

(21 citation statements)

References 89 publications

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“…As a first-line therapy, intravitreal injection of antivascular endothelial growth factor (VEGF) agents is effective in patients with nAMD because it targets pathological CNV (Kovach et al, 2012;Ferrara and Adamis, 2016). However, the limitations of anti-VEGF therapy should not be ignored, such as the side effects of the injection (Xi, 2020) and the unsatisfactory duration of the therapeutic effect (Ehlken et al, 2019). In addition, long-term use of anti-VEGF therapy may lead to serious economic burdens, especially in developing countries and regions (Ruiz-Moreno et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Altered Fecal Microbiome and Metabolome in a Mouse Model of Choroidal Neovascularization

Cai

Huang

et al. 2021

Front. Microbiol.

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PurposeChoroidal neovascularization (CNV) is the defining feature of neovascular age-related macular degeneration (nAMD). Gut microbiota might be deeply involved in the pathogenesis of nAMD. This study aimed to reveal the roles of the gut microbiome and fecal metabolome in a mouse model of laser-induced CNV.MethodsThe feces of C57BL/6J mice with or without laser-induced CNV were collected. Multi-omics analyses, including 16S rRNA gene sequencing and untargeted metabolomics, were conducted to analyze the changes in the gut microbial composition and the fecal metabolomic profiles in CNV mice.ResultsThe gut microbiota was significantly altered in CNV mice. The abundance of Candidatus_Saccharimonas was significantly upregulated in the feces of CNV mice, while 16 genera, including Prevotellaceae_NK3B31_group, Candidatus_Soleaferrea, and Truepera, were significantly more abundant in the controls than in the CNV group. Fecal metabolomics identified 73 altered metabolites (including 52 strongly significantly altered metabolites) in CNV mice compared to control mice. Correlation analysis indicated significant correlations between the altered fecal metabolites and gut microbiota genera, such as Lachnospiraceae_UCG-001 and Candidatus_Saccharimonas. Moreover, KEGG analysis revealed six pathways associated with these altered metabolites, such as the ABC transporter, primary bile acid biosynthesis and steroid hormone biosynthesis pathways.ConclusionThe study identified an altered fecal microbiome and metabolome in a CNV mouse model. The altered microbes, metabolites and the involved pathways might be associated with the pathogenesis of nAMD.

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Section: Introductionmentioning

confidence: 99%

Altered Fecal Microbiome and Metabolome in a Mouse Model of Choroidal Neovascularization

Cai

Huang

et al. 2021

Front. Microbiol.

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“…Pigment epithelium derived factor (PEDF) is a glycoprotein with a molecular weight of 50 kDa [ 99 ]. It is the most effective neoangiogenesis inhibitor [ 100 ].…”

Section: Resultsmentioning

confidence: 99%

Tenascin-C: A Key Regulator in Angiogenesis during Wound Healing

Wang

Líu

2022

Biomolecules

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(1) Background: Injury repair is a complex physiological process in which multiple cells and molecules are involved. Tenascin-C (TNC), an extracellular matrix (ECM) glycoprotein, is essential for angiogenesis during wound healing. This study aims to provide a comprehensive review of the dynamic changes and functions of TNC throughout tissue regeneration and to present an up-to-date synthesis of the body of knowledge pointing to multiple mechanisms of TNC at different restoration stages. (2) Methods: A review of the PubMed database was performed to include all studies describing the pathological processes of damage restoration and the role, structure, expression, and function of TNC in post-injury treatment; (3) Results: In this review, we first introduced the construction and expression signature of TNC. Then, the role of TNC during the process of damage restoration was introduced. We highlight the temporal heterogeneity of TNC levels at different restoration stages. Furthermore, we are surprised to find that post-injury angiogenesis is dynamically consistent with changes in TNC. Finally, we discuss the strategies for TNC in post-injury treatment. (4) Conclusions: The dynamic expression of TNC has a significant impact on angiogenesis and healing wounds and counters many negative aspects of poorly healing wounds, such as excessive inflammation, ischemia, scarring, and wound infection.

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“…RPE cells produce a range of angiogenic factors, including VEGF and PEDF, which are strongly related to the development of chorioretinal diseases [ 7 ]. VEGF is a key factor promoting angiogenesis and vascular permeability [ 13 ]. It is a mitogen and chemokine of vascular endothelial cells responsible for cell division and proliferation.…”

Section: Discussionmentioning

confidence: 99%

“…So far, the key role of these cytokines has been confirmed in the pathogenesis of age-related macular degeneration (AMD) [ 8 , 9 , 10 , 11 ]. Importantly, AMD and CSC share some similarities, such as disturbances in the levels of proangiogenic and antiangiogenic factors [ 12 , 13 ] and the presence of hyperpermeability. Moreover, they both can be complicated by choroidal neovascularization (CNV).…”

Section: Introductionmentioning

confidence: 99%

Changes in Plasma VEGF and PEDF Levels in Patients with Central Serous Chorioretinopathy

et al. 2021

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Background and Objectives: Retinal pigment epitheliopathy and hyperpermeability of choroidal vessels were postulated to be involved in the pathogenesis of central serous chorioretinopathy (CSC). Imbalanced levels of vascular endothelial growth factor (VEGF) and pigment-epithelium–derived factor (PEDF) were previously implicated in the development of chorioretinal diseases characterized by increased vascular permeability. We aimed to compare the plasma levels of proangiogenic VEGF and antiangiogenic PEDF for 26 patients with acute CSC, 26 patients with chronic CSC, and 19 controls. Materials and Methods: VEGF and PEDF levels were measured using a multiplex immunoassay or enzyme-linked immunosorbent assay. Correlations with disease duration were assessed. Results: VEGF levels differed between groups (p = 0.001). They were lower in patients with acute CSC (p = 0.042) and chronic CSC (p = 0.018) than in controls. PEDF levels were similar in all groups. The VEGF-to-PEDF ratio was lower in CSC patients than in controls (p = 0.04). A negative correlation with disease duration was noted only for PEDF levels in the group with chronic CSC (rho = −0.46, p = 0.017). Discussion: Our study confirmed that patients with CSC have imbalanced levels of VEGF and PEDF. This finding may have important implications for the pathogenesis of CSC. VEGF-independent arteriogenesis rather than angiogenesis may underlie vascular abnormalities in these patients.

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Pigment Epithelium-Derived Factor as a Possible Treatment Agent for Choroidal Neovascularization

Cited by 21 publications

References 89 publications

Altered Fecal Microbiome and Metabolome in a Mouse Model of Choroidal Neovascularization

Altered Fecal Microbiome and Metabolome in a Mouse Model of Choroidal Neovascularization

Tenascin-C: A Key Regulator in Angiogenesis during Wound Healing

Changes in Plasma VEGF and PEDF Levels in Patients with Central Serous Chorioretinopathy

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