Pigment vs cholesterol cholelithiasis: Comparison of stone and bile composition

Trotman, Bruce W.; Ostrow, J. Donald; Soloway, Roger D.; Cheong, E.; Longyear, Regina B.

doi:10.1007/bf01073011

Cited by 174 publications

(54 citation statements)

References 20 publications

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“…We compare responses to 2 population-based surveys completed before and after introduction of the new labels to address 3 questions: (1) Has there been an increase in the proportion ofpersons reading and using nutrition labels? (2) Have there been changes in the information people most often use? and (3) Do people report fewer barriers to using nutrition labels?…”

Section: Introductionmentioning

confidence: 99%

Serum ascorbic acid and other correlates of gallbladder disease among US adults.

Simon¹,

Hudes²

1998

Am J Public Health

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OBJECTIVES: This study examined the correlates of clinical gallbladder disease among US adults and whether serum ascorbic acid levels are associated with a decreased prevalence of gallbladder disease. METHODS: Cross-sectional analyses of data from the Second National Health and Nutrition Examination Survey were conducted. RESULTS: A total of 384 women (8%) and 107 men (3%) reported a history of gallstone disease, and 347 women (7%) and 81 men (2%) reported a history of cholecystectomy. An inverted U-shaped relation was found between serum ascorbic acid level and clinical gallbladder disease among women but not among men. CONCLUSIONS: Ascorbic acid, which affects the catabolism of cholesterol to bile acids and, in turn, the development of gallbladder disease in experimental animals, may reduce the risk of clinical gallbladder disease in humans.

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Section: Introductionmentioning

confidence: 99%

Serum ascorbic acid and other correlates of gallbladder disease among US adults.

Simon¹,

Hudes²

1998

Am J Public Health

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“…Gallstones were divided into cholesterol (dry weight Ͼ 50% cholesterol), pigment (Ͻ 20% cholesterol), and mixed (20% Ͻ cholesterol Ͻ 50%) gallstone types. 14 Gallbladder sludge was defined as sandy debris in the gallbladder visualized after cholecystectomy. We arbitrarily set gallbladder sludge size at 0.5 mm.…”

Section: Methodsmentioning

confidence: 99%

Small gallstones, preserved gallbladder motility, and fast crystallization are associated with pancreatitis†‡

et al. 2005

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Acute pancreatitis is a severe complication of gallstones with considerable mortality. We sought to explore the potential risk factors for biliary pancreatitis. We compared postprandial gallbladder motility (via ultrasonography) and, after subsequent cholecystectomy, numbers, sizes, and types of gallstones; gallbladder bile composition; and cholesterol crystallization in 21 gallstone patients with previous pancreatitis and 30 patients with uncomplicated symptomatic gallstones. Gallbladder motility was stronger in pancreatitis patients than in patients with uncomplicated symptomatic gallstones (minimum postprandial gallbladder volumes: 5.8 ؎ 1.0 vs. 8.1 ؎ 0.7 mL; P ‫؍‬ .005). Pancreatitis patients had more often sludge (41% vs. 13%; P ‫؍‬ .03) and smaller and more gallstones than patients with symptomatic gallstones (smallest stone diameters: 2 ؎ 1 vs. 8 ؎ 2 mm; P ‫؍‬ .001). Also, crystallization occurred much faster in the bile of pancreatitis patients (1.0 ؎ 0.0 vs. 2.5 ؎ 0.4 days; P < .001), possibly because of higher mucin concentrations (3.3 ؎ 1.9 vs. 0.8 ؎ 0.2 mg/mL; P ‫؍‬ .04). No significant differences were found in types of gallstones, relative biliary lipid contents, cholesterol saturation indexes, bile salt species composition, phospholipid classes, total protein or immunoglobulin (G, M, and A), haptoglobin, and ␣-1 acid glycoprotein concentrations. In conclusion, patients with small gallbladder stones and/or preserved gallbladder motility are at increased risk of pancreatitis. The potential benefit of prophylactic cholecystectomy in this patient category has yet to be explored. (HEPATOLOGY 2005;41:738-746.)

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“…3). The majority of these stones are of the calcium-bilirubinate type [17], which differs from pure cholesterol and black pigment stones in their composition and etiology [30]. Bacterial infection, bile stasis and an alteration of the bile composition are thought to be responsible for the nucleation, formation and maturation of intrahepatic stones [17].…”

Section: Muc Expression In the Biliary Tract With Hepatolithiasismentioning

confidence: 99%

Expression Profiles of MUC Mucin Core Protein in the Intrahepatic Biliary System: Physiological Distribution and Pathological Significance

Sasaki

Ikeda

Nakanuma

2005

Acta Histochem. Cytochem

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Mucin secreted by mucosal epithelial cells plays a role in the protection of the mucosal surface and also is involved in pathological processes. So far, MUC1-4, 5AC, 5B, 6-8, 11-13 and 15-17 genes coding the backbone mucin core protein have been identified in humans. Their diverse physiological distribution and pathological alterations have been reported. We have studied the expression profiles of MUC genes in the intrahepatic biliary system in developmental, normal and diseased livers using immunohistochemistry and in situ hybridization. Fetal intrahepatic bile ducts and ductal plates frequently express MUC1, while intrahepatic large bile ducts after birth express mainly MUC3 mucin. In hepatolithiasis, MUC5AC (gastric foveolar epithelial type) and MUC6 (pyloric gland type) mucins are newly expressed in surface epithelial cells and proliferated peribiliary glands, respectively, and the expression of gel-forming mucin may play a role in lithogenesis. Most biliary epithelial dysplasias and cholangiocarcinomas associated with hepatolithiasis expressed MUC5AC, suggesting that intrahepatic bile ducts express the gastric foveolar phenotype during carcinogenesis. In addition, intestinal metaplasia, intraductal papillary tumor and mucinous carcinoma, characterized by MUC2 expression, are occasionally associated with hepatolithiasis in a CDX2 homeobox gene-dependent manner. These findings may suggest the presence of intestinal metaplasia-related carcinogenesis in the intrahepatic biliary system as in the stomach.

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Pigment vs cholesterol cholelithiasis: Comparison of stone and bile composition

Cited by 174 publications

References 20 publications

Serum ascorbic acid and other correlates of gallbladder disease among US adults.

Serum ascorbic acid and other correlates of gallbladder disease among US adults.

Small gallstones, preserved gallbladder motility, and fast crystallization are associated with pancreatitis†‡

Expression Profiles of MUC Mucin Core Protein in the Intrahepatic Biliary System: Physiological Distribution and Pathological Significance

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