Pigmentary and Other Dermatologic Manifestations of Minocycline: a reminder of adverse effects

Abstract

The applications of the tetracycline class of antibiotics extend beyond their antimicrobial activity to anti-inflammatory, immunosuppressive and neuroprotective applications, making it a commonly used class of medication. Minocycline, a second-generation tetracycline, has inherent characteristics that improve absorption and distribution. These benefits promote even more widespread use. This familiarity of usage breeds prescriptive complacency toward the dermatologic complications including hyperpigmentation. The following case explores these adverse manifestations of minocycline use.

Minocycline-Induced Gum Pigmentation during Treatment for Acne Vulgaris

“…One proposed mechanism of the hyperpigmentation is due to the accumulation of the minocycline derivatives that chelate to iron, calcium, and melanin [15,16]. Another proposed mechanism includes the formation of insoluble salts from minocycline, which is accumulated in di erent locations [17].…”