Pigmentary Retinopathy in Patients Receiving High Doses of a New Phenothiazine

Weekley, Robert D.; Potts, Albert M.; Reboton, Jose; May, Rupert H.

doi:10.1001/archopht.1960.01840010067005

Cited by 94 publications

(21 citation statements)

References 15 publications

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“…However, there are rare instances of disseminated chorioretinitis in which the ERG is absent. Various drugs can cause a pigmentary retinopathy, among which are thioridazine, chloroquine and hydroxychloroquine [22,2]. In this case, the patient had not assumed any of these drugs.…”

Section: Discussionmentioning

confidence: 83%

Unilateral retinitis pigmentosa associated with exfoliation syndrome

1988

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A case of a 71-year-old woman showing pigmentary degeneration of the retina associated with posterior subcapsular cataract in one eye, with a normal fellow eye, is presented. Clinical examinations of the patient were performed in order to rule out the various causes which are known to produce funduscopic features that mimic retinitis pigmentosa. Since these investigations were all negative, the fundus changes were interpreted as a unilateral retinitis pigmentosa. One year later, the patient was re-examined and an exfoliation syndrome was discovered in the affected eye, while the fellow eye was unchanged. An association of unilateral retinitis pigmentosa and exfoliation syndrome in the same eye can be regarded as exceptional. The possibility of a correlation of the pathogenetic mechanisms involved in the development of both conditions is discussed.

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Section: Discussionmentioning

confidence: 83%

Unilateral retinitis pigmentosa associated with exfoliation syndrome

1988

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“…Chloroquine and thioridazine bind to me lanin and induce a retinopathy [1,2,5,13,16]. Although a retinal toxicity of befunolol has been suggested [9], the ocular side effects of p-adrenergic-blocking agents remain un certain.…”

Section: Discussionmentioning

confidence: 99%

Affinity of Drugs for Dopa-Auto-Oxidation Melanin and Tyrosinase-Catalyzed Dopa-Melanin in vitro

et al. 1988

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We examined spectrophotometrically the ability of drugs to bind with dopa-auto-oxidation melanin or tyrosinase-catalyzed dopa-melanin. Each drug, at 5 × 10^-5M, was incubated at 37 °C for 8h with 0.4 mg of synthetic melanins in 20 mM potassium phosphate buffer at pH 7.0 or in 20 mM acetate buffer at pH 4.8. Chloroquine, thioridazine, befunolol, pindolol, daunomycin and 5-fiuorouracil bound to melanin at pH 7.0 and 4.8. Methotrexate bound to melanin at pH 4.8, but not at pH 7.0. Pilocarpine, epinephrine, acy-clovir, vincristine and colchicine did not bind to dopa-auto-oxidation melanin or tyrosinase-catalyzed dopa-melanin.

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“…It is known that phenothiazines are con centrated in uvea of eyes (10,21,22), and that a long-term administration of phenothiazines (23,24) or chloroquine (25) injures uvea and retina. One of the mechanisms of the injury is considered to be the association of these drugs with melanin in eyes (10,25).…”

Section: Discussionmentioning

confidence: 99%

Flavin and Melanin in Cat and Dog Choroids

Matsui

Yanagiya

1973

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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The association of RF2 with melanin from cat and dog choroids was shown by dialysis and spectrophotometric methods. The association obeyed Freundlich's isotherm, and RF was liberated from RF-melanin complex by gel chromatography and by addition of CPZ. The liberation of flavin from cat choroid was not affected by Pronase treatment, though that from kidney was accelerated. It was also shown that flavins in cat choroid are not degraded by illumination. From above findings it was deduced that most of flavin in cat and dog choroids is associated with melanin.In previous reports we found that the flavin content in cat choroid was related to the presence of melanin (1), and that the extraction of flavin from cat choroid was apparently more difficult than from liver and kidney (2). Similar relation was also reported by Aso et al. (3) in human and animal skin and hair, and it is well known that flavin associates with many aromatic compounds (4). In this report we show that RF associates with melanin and that flavin in the choroids is in associated form with melanin.

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Pigmentary Retinopathy in Patients Receiving High Doses of a New Phenothiazine

Cited by 94 publications

References 15 publications

Unilateral retinitis pigmentosa associated with exfoliation syndrome

Unilateral retinitis pigmentosa associated with exfoliation syndrome

Affinity of Drugs for Dopa-Auto-Oxidation Melanin and Tyrosinase-Catalyzed Dopa-Melanin in vitro

Flavin and Melanin in Cat and Dog Choroids

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