Pigmented atypical fibroxanthoma

Díaz‐Cascajo, Carlos; Borghi, Susanna; Bonczkowitz, Matthias

doi:10.1046/j.1365-2559.1998.00567.x

Cited by 51 publications

(31 citation statements)

References 17 publications

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“…25,26 In addition, pigmented variants of AFX mimicking melanoma have been reported in the literature. 27 LMSs are most frequently found in young adults presenting as painful subcutaneous nodules on the extremities. Superficial cutaneous LMSa are rarely encountered spindle cell tumors of sun-damaged skin.…”

Section: Discussionmentioning

confidence: 99%

P75 Nerve Growth Factor Receptor as a Useful Marker to Distinguish Spindle Cell Melanoma From Other Spindle Cell Neoplasms of Sun-Damaged Skin

Sigal

Keenan

Lazova

2012

The American Journal of Dermatopathology

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P75 nerve growth factor receptor (p75 NGF-R) is a low-affinity receptor expressed on the surface of neural crest-derived cells and in a variety of neural tumors. Strong p75 NGF-R expression has been found in spindle cell melanoma (SCM). We studied spindle cell neoplasms of sun-damaged skin to determine whether this marker can reliably distinguish between SCM and other spindle cell malignancies. We evaluated the staining of p75 NGF-R, S100, and HMB-45 in 11 cases of SCM, 16 cases of spindle cell squamous cell carcinoma (SCSCC), 19 cases of spindle cell atypical fibroxanthoma, 6 cases of cutaneous leiomyosarcoma, and 20 scars. Staining with p75 NGF-R was positive in all 11 of 11 (100%) cases of SCM, whereas S100 stained 10 of 11 (91%) cases, and HMB-45 was negative in all SCMs. In addition, there was superior intensity of the staining for p75 NGF-R in comparison to S100. P75-NGF-R showed focal positivity in 3 of 16 (19%) cases of SCSCC. None of the rest of the cases of SCSCC, and none of the cases of spindle cell atypical fibroxanthoma, cutaneous leiomyosarcoma, and scars expressed p75 NGF-R, S100, or HMB-45. P75 NGF-R is a useful marker to distinguish SCM from other spindle cell neoplasms of sun-damaged skin. This marker exhibits greater sensitivity than S100 in identifying SCM and may be a useful diagnostic and ancillary stain especially in the setting of an S100 negative spindle cell neoplasm.

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Section: Discussionmentioning

confidence: 99%

P75 Nerve Growth Factor Receptor as a Useful Marker to Distinguish Spindle Cell Melanoma From Other Spindle Cell Neoplasms of Sun-Damaged Skin

Sigal

Keenan

Lazova

2012

The American Journal of Dermatopathology

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“…Pigmented AFX was described by Díaz-Cascajo et al 1 in 1998 in a series of four cases. In 2003, the authors added five additional cases to this series.…”

Section: Discussionmentioning

confidence: 84%

A nodule on the scalp of an elderly patient

et al. 2015

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“…Histologically, these lesions overlap with benign lesions such as common or cellular blue nevi, desmoplastic nevi, and pigmented neurofibromas and with malignant lesions such as pigmented atypical fibroxanthoma, melanoma, and Bednar tumors, if they have some atypical cells. 14,15 In the vast majority of nevi and melanoma, the nonpigmented lesional cells express S100 and/or specific melanocytic markers, whereas pigmented fibrous proliferations, including dermatofibromas and DFSPs, would be negative for these markers. Although pigmented neurofibromas can express CD34, like other neural lesions, this possibility can be excluded from the differential diagnosis by a negative S100.…”

Section: Discussionmentioning

confidence: 99%

CD34+ Pigmented Fibrous Proliferations: The Morphologic Overlap Between Pigmented Dermatofibromas and Bednar Tumors

McAllister¹,

Recht²,

Hoffman³

et al. 2008

The American Journal of Dermatopathology

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Pigmented dermatofibrosarcoma protuberans (DFSP; Bednar tumor) constitutes 5%-10% of all cases of DFSP and shows morphologic features that overlap with melanocytic and fibrous proliferations. We report 2 unusual cases of pigmented fibrous proliferations that demonstrate features of dermatofibromas and DFSP. The first case is that of a 19-year-old man with a 3-year history of a slowly growing pigmented lesion on the right arm. On clinical exam, the lesion was a 7-mm firm pigmented papulonodular lesion. The second case is that of a 31-year-old woman with a 4- to 5-year history of a slowly enlarging, asymptomatic "dark area" on the right buttock. On clinical exam, the lesion was a 2-cm darkly pigmented flat nodule. Morphologically, both lesions are primarily dermal proliferations of spindled cells admixed with pigmented dendritic melanocytes. The lesional cells trap collagen fibers at the periphery and there is basal cell hyperpigmentation. Adnexal structures are effaced, but significant trapping of subcutaneous fat is not present. By immunohistochemistry, both lesions show focal CD34 positivity but are negative for Factor XIIIa and melanocytic markers. Although overlap between standard dermatofibromas and DFSP is well documented in the literature, pigmented fibrous lesions with features of both entities are not well described.

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Pigmented atypical fibroxanthoma

Abstract: Pigmented atypical fibroxanthoma represents a poorly recognized variant of the neoplasm that may be easily misinterpreted as malignant melanoma. To the best of our knowledge, this is the first report of erythrophagocytosis in atypical fibroxanthoma.

Cited by 51 publications

References 17 publications

P75 Nerve Growth Factor Receptor as a Useful Marker to Distinguish Spindle Cell Melanoma From Other Spindle Cell Neoplasms of Sun-Damaged Skin

P75 Nerve Growth Factor Receptor as a Useful Marker to Distinguish Spindle Cell Melanoma From Other Spindle Cell Neoplasms of Sun-Damaged Skin

A nodule on the scalp of an elderly patient

CD34+ Pigmented Fibrous Proliferations: The Morphologic Overlap Between Pigmented Dermatofibromas and Bednar Tumors

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