Pigmented epithelioid melanocytoma: A case report

Oliveira, Renan Tironi Giglio de; Landman, Gilles; Locatelli, D.; Muzy, Guilherme; Moraes, Ana Flavia; Paschoal, Francisco Macedo

doi:10.1111/cup.13584

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…The histopathological features suggestive of PEM are a cellular element proliferation with epithelioid cytoplasm containing melanin pigment infiltrating the papillary dermis in blocks. In immunohistochemistry studies, PEM demonstrates positivity for Melan A, HMB-45, and S-100 [ 17 , 18 ]. PEM has been described as behaving less aggressively than conventional melanomas.…”

Section: Discussionmentioning

confidence: 99%

Pigmented epithelioid melanocytoma (PEM) of the spine with compression fracture: case report

Nepal

Santipas

Yotchai

et al. 2022

BMC Musculoskelet Disord

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Background Pigmented epithelioid melanocytoma (PEM) is a sporadic type of pigmented melanocytic tumor with uncertain malignant potential. PEM arises as a solitary neoplasm that predominantly occurs spontaneously in otherwise healthy patients. Due to its rarity, a gold standard treatment regimen does not exist; however, symptomatic cases should be managed with radiotherapy and surgery. Case presentation A 28-year-old Thai female presented with a sudden onset of back pain and weakness of the lower extremities during the postpartum period. Magnetic resonance imaging demonstrated abnormal soft tissue formation from T4 to T7; it extended to the vertebral bodies, left neural foramina, and posterior columns of T6 and T7. The patient underwent complete tumor debulking, decompressive laminectomy from T4 to T8, and posterior instrumentation from T3 to T10. The histopathology and immunohistochemistry suggested PEM. The patient fully resolved back pain after surgery. Nevertheless, as the patient re-presented with a neurological deficit a few months after the operative intervention, it was decided to perform a surgical resection via an en bloc vertebrectomy. At the one-year follow-up, although the patient reported continued improvement of her back pain, there was no motor power improvement. Conclusions Spinal cord compression due to PEM is uncommon, especially in adults. Early diagnosis and treatment provide a good prognosis and help to regain lost neurological functions. Complete tumor removal and decompression of the spinal cord must be considered as a treatment strategy. Perioperative radiotherapy and chemotherapy have also been highlighted as treatment modalities for spinal tumors. With our reported case, early operative intervention coupled with radiotherapy produced satisfying outcomes.

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Section: Discussionmentioning

confidence: 99%

Pigmented epithelioid melanocytoma (PEM) of the spine with compression fracture: case report

Nepal

Santipas

Yotchai

et al. 2022

BMC Musculoskelet Disord

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Integrated Bioinformatics Analysis Exhibits Pivotal Exercise-Induced Genes and Corresponding Pathways in Malignant Melanoma

Zhu¹,

Hao²,

Zhang³

et al. 2021

Front. Genet.

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Malignant melanoma represents a sort of neoplasm deriving from melanocytes or cells developing from melanocytes. The balance of energy and energy-associated body composition and body mass index could be altered by exercise, thereby directly affecting the microenvironment of neoplasm. However, few studies have examined the mechanism of genes induced by exercise and the pathways involved in melanoma. This study used three separate datasets to perform comprehensive bioinformatics analysis and then screened the probable genes and pathways in the process of exercise-promoted melanoma. In total, 1,627 differentially expressed genes (DEGs) induced by exercise were recognized. All selected genes were largely enriched in NF-kappa B, Chemokine signaling pathways, and the immune response after gene set enrichment analysis. The protein-protein interaction network was applied to excavate DEGs and identified the most relevant and pivotal genes. The top 6 hub genes (Itgb2, Wdfy4, Itgam, Cybb, Mmp2, and Parp14) were identified, and importantly, 5 hub genes (Itgb2, Wdfy4, Itgam, Cybb, and Parp14) were related to weak disease-free survival and overall survival (OS). In conclusion, our findings demonstrate the prognostic value of exercise-induced genes and uncovered the pathways of these genes in melanoma, implying that these genes might act as prognostic biomarkers for melanoma.

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Pigmented epithelioid melanocytoma: A case report

Cited by 2 publications

References 7 publications

Pigmented epithelioid melanocytoma (PEM) of the spine with compression fracture: case report

Pigmented epithelioid melanocytoma (PEM) of the spine with compression fracture: case report

Integrated Bioinformatics Analysis Exhibits Pivotal Exercise-Induced Genes and Corresponding Pathways in Malignant Melanoma

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