Pigmented epithelioid melanocytoma (animal-type melanoma): An institutional experience

Bax, Michael J.; Brown, Marc D.; Rothberg, Paul G.; Laughlin, Todd S.; Scott, Glynis

doi:10.1016/j.jaad.2017.01.029

Cited by 27 publications

(29 citation statements)

References 18 publications

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“…Other genetic alterations in specific genes relevant to melanocyte oncogenic transformation were not identified in this case. Table summarizes immunohistochemistry (IHC) for PrkaR1α, BRAF V600E, and p16 expression and molecular studies in PSMs and PEM …”

Section: Discussionmentioning

confidence: 99%

Distant metastasis due to heavily pigmented epithelioid melanoma with underlying BRAF V600E, NOTCH1, ERBB3, and PTEN mutations

2019

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Pigment-synthesizing melanoma (PSM) describes a morphologically and genetically diverse group of melanomas. In contrast, pigmented epithelioid melanocytoma (PEM) encompasses a spectrum of indolent tumors now classified as borderline/intermediate melanocytic tumors. Herein, we report a case of widely metastatic heavily pigmented epithelioid melanoma with fatal outcome in a 36-year-old woman. Nextgeneration sequencing identified somatic (tumoral) mutations in BRAF V600E, PTEN, NOTCH1, and ERBB3. By contrast, GNAQ and GNA11 were wild type. Prkar1α and p16 expression were maintained. Identification of mutations in NOTCH1 and ERBB3 may support the diagnosis of heavily pigmented epithelioid melanoma. In contrast, PRKCA fusion genes and PRKAR1A mutations support the diagnosis of PEM. Given the heterogeneity, potential overlap (loss of Prkar1α expression), and evolving genetic profiles of these two distinct groups of tumors, careful appraisal of molecular profiles in the light of histomorphology and clinical history is necessary for distinction between PEM and PSMs including heavily pigmented epithelioid melanomas, with significant potential impact on prognosis and therapy. K E Y W O R D S BRAF V600E, ERBB3, next-generation sequencing, NOTCH1, pigmented epithelioid melanocytoma, pigment-synthesizing melanoma, PTEN

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Section: Discussionmentioning

confidence: 99%

Distant metastasis due to heavily pigmented epithelioid melanoma with underlying BRAF V600E, NOTCH1, ERBB3, and PTEN mutations

2019

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“…Herein this entity was highlighted and revisited in brief. 1,7 ; therefore, although the tumor can be lethal given the depth of invasion according to Magro and colleagues, it seems to be less lethal than other usual or unusual vertical growth phase melanomas 1,2 . Local lymph nodes are often involved by metastases.…”

Section: Luca Roncati Francesco Piscioli Idmentioning

confidence: 95%

“…Up to day, only small series have been reported in humans and, therefore, its biological behavior remains unclear. Recently, some authors have supported that the tumor follows an indolent clinical course, with very low risk of spread beyond regional lymph nodes 2 . Given the complexity of the matter, Elder and Murphy proposed a histological categorization of PEM and PEM-like lesions, with distinctive clinicopathological and biologic features 3 .…”

Section: Luca Roncati Francesco Piscioli Idmentioning

confidence: 99%

Animal-type melanoma: an unusual variant of human melanoma with prominent pigment synthesis and unpredictable course

Roncati¹,

Piscioli²

2018

MMJ

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“…Pigmented epithelioid melanocytoma (PEM), also known as an animal-type melanoma, is a distinctive group of melanocytic tumors with a more favorable prognosis than conventional melanoma [ 1 , 2 , 3 ]. The typical PEM contains an aggregation of histiocytes in the center of the tumor, which is useful for the differential diagnosis against nodular melanomas or cellular blue nevus [ 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Pigmented Epithelioid Melanocytoma (Animal Types of Melanoma) on the Nose

Ohuchi¹,

Fujimura²,

Kambayashi³

et al. 2018

Case Rep Oncol

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Pigmented epithelioid melanocytoma (PEM), also known as an animal-type melanoma, is a distinctive group of melanocytic tumors with a more favorable prognosis than conventional melanoma. Since tumor-associated macrophages (TAMs) extend in the premetastatic lymph nodes in several cancers, we hypothesized that the lower rate of lymph node metastasis in PEM might be correlated with the phenotypes of TAMs. Therefore, in this report, we further investigate the subpopulation of TAMs in PEM, revealing that the main population of TAMs in histiocytic lesion is CD163+CD206+PD-L1+ M2-polarized macrophages. In addition, since the PD-L1-expressing CD205+ dendritic cells are also detected in histiocytic lesions, the PD-L1-expressing TAMs and dendritic cells might suggest favorable prognostic factors in patients with PEM.

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Pigmented epithelioid melanocytoma (animal-type melanoma): An institutional experience

Cited by 27 publications

References 18 publications

Distant metastasis due to heavily pigmented epithelioid melanoma with underlying BRAF V600E, NOTCH1, ERBB3, and PTEN mutations

Distant metastasis due to heavily pigmented epithelioid melanoma with underlying BRAF V600E, NOTCH1, ERBB3, and PTEN mutations

Animal-type melanoma: an unusual variant of human melanoma with prominent pigment synthesis and unpredictable course

Pigmented Epithelioid Melanocytoma (Animal Types of Melanoma) on the Nose

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