Pigmented epitheloid melanocytoma: a low grade/intermediate/ borderline melanoma

Neelam, Sreemani Kumari; Nandyala, Venkata Narasimha Reddy; Srujana, Shyamala; Pallam, Praveen; Chintakindi, Santosh Babu; Odapally, Shravan Kumar

doi:10.18203/2349-2902.isj20160269

Cited by 1 publication

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“…Patients with equivocal ATM were younger with a median age 12 versus 53 years, and had a lower rate of positive lymph nodes compared with unequivocal ATM thus suggesting molecular differences to justify differential clinical behaviour (Ref 36). Immunoistochemistry of ATM is positive for S-100 protein, HMB-45, vimentin and Melan-A (Refs 4, 36, 37, 38, 39) and testing CD68 is useful to differentiate pigmented melanocytic cells from melanophages. The principal differential diagnosis of ATM or PEM are summarised in Table 1 (Refs 2, 4, 15, 16, 33, 39, 40).…”

Section: Review Of the Literaturementioning

confidence: 99%

Animal-type melanoma: dog or wolf? A review of the literature and a case report

Stucci

Palmirotta

Lovero

et al. 2018

Expert Rev. Mol. Med.

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The human animal type melanoma (ATM) is a rare subtype of melanoma characterised by the proliferation of pigmented dermal epithelioid and spindled melanocytes. However, this variant of melanoma is still lacking a precise nosography definition and classification for the difficulty to be distinguished from other more common melanocytic lesions, as well as for its peculiar biological behaviour. On the other hand, the contribution of scientific literature to this issue is fragmented and limited to the description of very few cases. Starting from the presentation of a case with abnormally aggressive clinical features, here we revisit the current knowledge on ATM from its dermatologic patterns, epidemiology, demography and histopathology to the clinical management. Peculiar accuracy has also been reserved to several histopathologic criteria, which are critical for the differential diagnosis from other melanocytic diseases in junction with molecular data deriving from recent cytogenetic and mutational characterisation of this tumour.

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