Pigmented lesions of the oral mucosa: A cross‐sectional study of 458 histopathological specimens

Tavares, Thalita Soares; Meirelles, Daniela Pereira; Aguiar, Maria Cássia Ferreira de; Caldeira, Patrícia Carlos

doi:10.1111/odi.12924

Cited by 43 publications

(90 citation statements)

References 17 publications

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“…Acometem a região cutânea com maior frequência, contudo, na cavidade oral são lesões incomuns (Müller, 2010;Buchner et al, 2004;Gondak et al, 2012;Ferreira et al, 2015;Natarajan, 2019;Freitas et al, 2015;Lambertini et al, 2017). De acordo com a literatura, nota-se uma prevalência de acometimento na terceira e quarta década de vida (Buchner et al, 2004;Freitas et al, 2015;Tavares et al, 2018), e exibem uma variação de ocorrência entre 3 a 85 anos (Müller, 2010;Buchner et al, 2004;Ferreira et al, 2015). Há uma correlação entre a média de idade e o subtipo histológico do nevo oral, por exemplo, a idade média apresentada por pacientes diagnosticados com nevo juncional variou entre 6 a 12 anos (Buchner et al, 2004;Ferreira et al, 2015;Tavares et al, 2018), nevo composto variou entre 18 a 23 anos (Buchner et al, 2004;Ferreira et al, 2015;Tavares et al, 2018), nevo intramucoso variou entre 31 a 35,1 anos (Buchner et al, 2004;Ferreira et al, 2015;Tavares et al, 2018) e em pacientes diagnosticados com nevo azul a variação ocorreu entre 40 a 48,7 anos de idade (Buchner et al, 2004;Ferreira et al, 2015;Tavares et al, 2018).…”

Section: Discussionunclassified

“…Sua aparência clínica pode mimetizar a do melanoma em estágios iniciais, o que o torna seu principal diagnóstico diferencial (Kauzman et al, 2004;Buchner et al, 2004;Gondak et al, 2012;Freitas et al, 2015). Histopatologicamente são classificados em nevo juncional, nevo composto, nevo intradérmico ou intramucoso, nevo azul comum, nevo combinado, nevo displásico, nevo de Spitz e nevo azul celular (Vasconcelos et al, 2014;Research, Society and Development, v. 9, n. 11, e2409119815, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i11.9815 4 Buchner et al, 2004;Ferreira et al, 2015;Meleti, 2007;Natarajan, 2019;Freitas et al, 2015;Tavares, Meirelles, de Aguiar & Caldeira, 2018).…”

Section: Introductionunclassified

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Nevo oral intramucoso: relato de caso

Santana¹,

Santos

Ávila

et al. 2020

RSD

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Paciente se apresentou com uma queixa principal de “surgiu uma mancha na minha gengiva”. A anamnese e o exame físico extraoral não demonstraram alteração. Já no exame físico intraoral, observou-se uma lesão enegrecida localizada em gengiva inserida. Foi proposto, então, o procedimento de biópsia excisional para investigar a possibilidade diagnóstica de melanoma oral em estágio inicial. O resultado do exame histopatológico descartou a hipótese diagnóstica de lesão maligna e possibilitou o diagnóstico definitivo de nevo oral intramucoso. O paciente encontra-se em acompanhamento há dois anos, sem sinais de recidiva. As lesões orais pigmentadas apresentam uma variedade etiológica e podem apresentar, também, características clínicas semelhantes entre si, em especial, o nevo melanocítico oral e o melanoma oral. Portanto, para a obtenção de um diagnóstico seguro e, consequentemente, para o estabelecimento do tratamento mais adequado frente a essas lesões, é importante realizar uma associação entre anamnese, exame clínico e exame histopatológico.

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Section: Discussionunclassified

Section: Introductionunclassified

Nevo oral intramucoso: relato de caso

Santana¹,

Santos

Ávila

et al. 2020

RSD

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“…Pigmentation is asymptomatic and no treatment is required except for aesthetic concerns. Moreover, color variation may be uniform, unilateral, bilateral, mottled, macular, or blotched and may either involve the gingival papillae alone, or extend throughout the gingiva and into other oral tissues [13]. Physiologic pigmentation clinically appears as multifocal or diffuse, with variable prevalence in different ethnic groups.…”

Section: Physiologic (Ethnic/racial) Gingival Pigmentationmentioning

confidence: 99%

The Pseudolesions of the Oral Mucosa: Differential Diagnosis and Related Systemic Conditions

et al. 2019

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Pseudolesions are defined as physiological or paraphysiological changes of the oral normal anatomy that can easily be misdiagnosed for pathological conditions such as potentially malignant lesions, infective and immune diseases, or neoplasms. Pseudolesions do not require treatment and a surgical or pharmacological approach can constitute an overtreatment indeed. This review aims to describe the most common pseudolesions of oral soft tissues, their possible differential diagnosis and eventual related systemic diseases or syndromes. The pseudolesions frequently observed in clinical practice and reported in literature include Fordyce granules, leukoedema, geographic tongue, fissured tongue, sublingual varices, lingual fimbriae, vallate papillae, white and black hairy tongue, Steno’s duct hypertrophy, lingual tonsil, white sponge nevus, racial gingival pigmentation, lingual thyroid, and eruptive cyst. They could be misdiagnosed as oral potential malignant disorders, candidiasis, Human Papilloma Virus (HPV)-related affections, oral autoimmune diseases, or benign and malignant tumors. In some cases, pseudolesions feature in a syndromic panel, for example, fissured tongue in Melkersson–Rosenthal syndrome. It is strictly fundamental for dentists to know and to distinguish oral pseudolesions from pathological conditions, in order to avoid overtreatment.

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“…1 Pigmentations can be caused by multiple factors such as dermatologic lesions, ethnicity, trauma, graphite, and amalgam particles. [2][3][4][5][6][7] The correct diagnosis is important in deciding the mode of treatment and the possible need for biopsy. [8][9][10][11][12] The etiology of the pigmentation and its depth in the tissue will influence which technique to use in eliminating or masking the discoloration.…”

Section: Introductionmentioning

confidence: 99%

Treatment of the amalgam tattoo in the esthetic zone

Mathews

2020

J Esthet Restor Dent

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Objective: When pigmentations appeared in the esthetic zone and were visible during the patient's smile, they were very disconcerting. There are multiple techniques to eradicate or ameliorate these discolorations. This article will address those pigmentations caused by amalgam particles. Clinical considerations: Keratinized gingival grafts were used to cover and mask these pigmentations. In addition, connective tissue grafts were used to aid in the elimination of the external pigmentation. Conclusions: Both techniques were shown to be very effective in masking or eliminating these unesthetic pigmentations. Long-term follow-up has shown these results to be stable with no recurrence of the pigmentation. Clinical significance: Unesthetic pigmentations in the esthetic zone that are visible during a patient's smile are very disconcerting. Elimination of these unesthetic discolorations can make a dramatic improvement in the patient's smile.

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Pigmented lesions of the oral mucosa: A cross‐sectional study of 458 histopathological specimens

Abstract: Pigmented lesions represent an uncommon diagnosis in oral pathology routines. The most frequent entities are amalgam tattoo, melanotic macule, and nevus. Patients are usually middle-aged women presenting a small, long-lasting, macular lesion on the cheek mucosa.

Cited by 43 publications

References 17 publications

Nevo oral intramucoso: relato de caso

Nevo oral intramucoso: relato de caso

The Pseudolesions of the Oral Mucosa: Differential Diagnosis and Related Systemic Conditions

Treatment of the amalgam tattoo in the esthetic zone

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