Pigmented mammary Paget disease mimicking melanoma on dermatoscopy

Yanagishita, Takeshi; Tamada, Yasuhiko; Tanaka, Masaru; Kasugai, Chikatoshi; Takahashi, Emiko; Matsumoto, Yoshinari; Watanabe, Daisuke

doi:10.1016/j.jaad.2010.09.717

Cited by 16 publications

(19 citation statements)

References 6 publications

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“…To our knowledge, six cases of pigmented MPD have been reported to date with dermoscopic findings. Five of these cases presented with irregular pigmentation, and four cases presented with irregular dots/globules and blue–white structures, including blue–white veil and regression structures . These six cases showed dermoscopic features similar to our case, and were indistinguishable from MM under dermoscopy.…”

Section: Discussionsupporting

confidence: 75%

Pigmented macule on the nipple

et al. 2015

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Section: Discussionsupporting

confidence: 75%

Pigmented macule on the nipple

et al. 2015

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“…However, Azzopardi and Eusebi 1 first described pigmented mammary Paget disease as a pigmentation of breast carcinoma in 1977. Currently, about 35 cases have been reported in the literature 2 . A possible explanation for the mechanism of hyperpigmentation was that Paget cells might induce the production of melanin from normal melanocytes 3 .…”

Section: Discussionmentioning

confidence: 99%

Pigmented Mammary Paget Disease Misdiagnosed as Malignant Melanoma

Lee

Kim

et al. 2014

Ann Dermatol

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“…On clinical grounds, MPD displays an unspecific morphologic pattern, usually manifesting as an ulcerated, crusted or scaly patch or plaque on the nipple that may extend to the areolar region . The clinical recognition of MPD is challenging, since it may closely simulate a variety of benign and malignant skin conditions . Early diagnosis is crucial to initiate detailed work‐up for the detection and management of the very probable underlying breast malignancy.…”

Section: Introductionmentioning

confidence: 99%

Dermoscopic features of mammary Paget’s disease: a retrospective case‐control study by the International Dermoscopy Society

Apalla

Errichetti

Kyrgidis

et al. 2019

Acad Dermatol Venereol

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Background Mammary Paget's disease (MPD) is a rare intraepidermal adenocarcinoma of the nipple-areola complex, associated with an underlying breast cancer in approximately 90% of cases. Delayed diagnosis of MPD is common. Its dermoscopic features have been ill defined in the literature. ObjectivesTo determine the clinical and dermoscopic features of MPD versus other dermatologic entities that involve nipple and areola.Methods Members of the IDS were invited to submit any case of histologically confirmed MPD, as well as other benign and malignant dermatoses that involve the nipple and areola complex. A standardized evaluation of the dermoscopic images was performed and the results were statistically analyzed.Results Sixty-five lesions were included in the study, 22 (33.8%) of them MPD and 43 (66.2%) controls. The most frequent dermoscopic criteria of MPD were white scales (86.4%) and pink structureless areas (81.8%), followed by dotted vessels (72.7%), erosion/ulceration (68.2%) and white shiny lines (63.6%). The multivariate analysis showed that white scales and pink structureless areas were significant predictors of MPD, posing a 68-fold and a 31-fold probability of MPD, respectively. Split of the population into pigmented and non-pigmented lesions showed that in pigmented MPD, pink structureless areas, white lines and grey granules and dots are positive predictors of the disease. Among nonpigmented lesions, pink structureless areas, white lines, erosion/ulceration and white scales served as predictors of MPD. Conclusions The most frequent profile of an individual with MPD is an elderly female with unilateral, asymptomatic, erythematous plaque of the nipple, dermoscopically displaying pink structureless areas, fine white scales, dotted and a few short linear vessels. In case of pigmentation we may also observe brown structureless areas and pigmented granules.Limitations Small sample size, retrospective design.

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Pigmented mammary Paget disease mimicking melanoma on dermatoscopy

Cited by 16 publications

References 6 publications

Pigmented macule on the nipple

Pigmented macule on the nipple

Pigmented Mammary Paget Disease Misdiagnosed as Malignant Melanoma

Dermoscopic features of mammary Paget’s disease: a retrospective case‐control study by the International Dermoscopy Society

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