Pigmented median raphe cyst of the penis with consideration of the possible mechanism of melanocytic colonization: A case report

Ishida, Mitsuaki; Iwai, Muneo; Yoshida, Keiko; Kagotani, Akiko; Okabe, Hidetoshi

doi:10.3892/ol.2013.1719

Cited by 5 publications

(10 citation statements)

References 11 publications

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“…There is also evidence that most of these factors (LTC4, bFGF, ET‐1, SDF‐1) are expressed by meningiomas, having a role in tumorigenesis and/or angiogenesis . However, tumors in different locations may have alternate mechanisms of melanocyte colonization . We immunostained for several molecules that have been reported to affect melanocyte migration .…”

Section: Discussionmentioning

confidence: 90%

“…[20][21][22][23] However, tumors in different locations may have alternate mechanisms of melanocyte colonization. 24 We immunostained for several molecules that have been reported to affect melanocyte migration. [17][18][19][20][21][22][23] We show that the receptor CD117 (c-Kit) is expressed in a subset of the recurrent tumor's melanocytes and that its ligand, SCF (KITL), is diffusely expressed in the meningioma cells.…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathologic features and pathogenesis of melanocytic colonization in atypical meningioma

Harati

Magaki

et al. 2017

Neuropathology

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Only two prior cases of benign dendritic melanocytes colonizing a meningioma have been reported. We add a third case, describe clinicopathologic features shared by the three, and elucidate the risk factors for this very rare phenomenon. A 29 year-old Hispanic woman presented with headache and hydrocephalus. MRI showed a lobulated enhancing pineal region mass measuring 41 mm in greatest dimension. Subtotal resection of the mass demonstrated an atypical meningioma, WHO grade II, and the patient subsequently underwent radiotherapy. She presented 4 years later with diplopia, and MRI showed an enhancing extra-axial mass measuring 47 mm in greatest dimension and centered on the tentorial incisura. Subtotal resection showed a brain-invasive atypical meningioma with melanocytic colonization. The previous two cases in the literature were atypical meningiomas, one of which was also brain invasive. Atypical meningiomas may be at particular risk for melanocytic colonization as they upregulate molecules known to be chemoattractants for melanocytes. We detected c-Kit expression in a minority of the melanocytes as well as stem cell factor and basic fibroblast growth factor in the meningioma cells, suggesting that mechanisms implicated in normal melanocyte migration may be involved. In some cases, brain invasion with disruption of the leptomeningeal barrier may also facilitate migration from the subarachnoid space into the tumor. Whether there is low-level proliferation of the dendritic melanocytes is unclear. Given that all three patients were non-Caucasian, meningiomas in persons and/or brain regions with increased dendritic melanocytes may predispose to colonization. The age range spanned from 6 years old to 70 years old. All three patients were female. The role of gender and estrogen in the pathogenesis of this entity remains to be clarified. Whether melanocytic colonization may also occur in the more common Grade I meningiomas awaits identification of additional cases.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Clinicopathologic features and pathogenesis of melanocytic colonization in atypical meningioma

Harati

Magaki

et al. 2017

Neuropathology

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“…Although extremely rare, MRCs containing melanin pigment and/or melanocytes (i.e. pigmented MRCs) have been reported, with six cases to date having been published 4,5,10,14,15 . Given that the cyst of our patient was lined mostly by non‐keratinizing stratified squamous epithelium and partially by stratified columnar epithelium (Fig.…”

Section: Discussionmentioning

confidence: 88%

“…MRCs are rare benign lesions of the male genitalia that can develop at any site along the midline from meatus to anus (i.e. parameatus, glans penis, penile shaft, scrotum, perineum, or perianal) 1–19 . The condition was first described by Mermet in 1895, 1 and MRC is currently believed to be caused by a defect in closure of the median raphe during embryonic development 19 .…”

Section: Introductionmentioning

confidence: 99%

Pigmented median raphe cyst of the penis that developed after middle age without infection or trauma history

Kii

Taguchi²,

Nagahama

et al. 2021

IJU Case Reports

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Introduction Median raphe cysts are rare benign lesions of the male genitalia that can develop anywhere along the midline from meatus to anus. They are believed to be caused by a defect in closure of median raphe during embryonic development. These cysts commonly appear in childhood or adolescence, although some are diagnosed after middle age, typically triggered by infection or trauma. Pigmented median raphe cysts, or those containing melanin pigment and/or melanocytes, are extremely rare. Case presentation A 78‐year‐old man visited our hospital with a complaint of a penile mass that he first noticed in his 50s which slowly grew, eventually causing voiding difficulty. He had no history of infection or trauma. The lesion was excised, and the pathological diagnosis was pigmented median raphe cyst. Conclusion We successfully treated a rare case of pigmented median raphe cyst of the penis that developed after middle age without infection or trauma history.

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“…As far as squamomelanocytic tumors are concerned, the prognosis is worse, since these tumors have a more aggressive behavior similar to that of malignant melanoma. However, Pool SE refers no relapse or metastases for three patients with squamomelanocytic tumor for a mean follow up of 3.25 years [46,47].…”

Section: Discussionmentioning

confidence: 99%

Pigmented Squamous Cell Carcinoma of the Lower Back Skin: A Case Report and Review of the Literature

Dimitra¹,

Vassiliki²,

Maria³

et al. 2015

Pigmentary Disorders

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Pigmented squamous cell carcinoma is a rare neoplasm arising mostly in mucous membranes or in sun-exposed skin. We describe a case of this tumor in a 70 year-old man who presented with a pigmented ulcerated nodule on his lower back. Microscopic examination revealed a squamous cell carcinoma (SCC) with atypical proliferation of cells with individual cell keratisation and keratin pearls' formation. Apart from the squamous cell carcinoma a population of cytologically bland dendritic melanocytes was also present, a process that has been described as tumor cell colonization. Differential diagnosis of pigmented SCC includes melanoma with pseudoepitheliomatous hyperplasia, pigmented metatypical basal cell carcinoma and squamomelanocytic tumor, a recently described combined tumor. A small number of cases of pigmented SCC have been referred in the literature mainly located in mucosal surfaces such as the oral and nasal cavity and the conjunctiva but also in sun-exposed cutaneous sites especially at the skin of the head. In the present study, a case of pigmented SCC arising in sun protected skin is described. The authors review the published literature and discuss the histologic differential diagnosis of pigmented SCC as well as the possible mechanisms of melanocytes' colonization in pigmented non-melanocytic malignant neoplasms.

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Pigmented median raphe cyst of the penis with consideration of the possible mechanism of melanocytic colonization: A case report

Cited by 5 publications

References 11 publications

Clinicopathologic features and pathogenesis of melanocytic colonization in atypical meningioma

Clinicopathologic features and pathogenesis of melanocytic colonization in atypical meningioma

Pigmented median raphe cyst of the penis that developed after middle age without infection or trauma history

Pigmented Squamous Cell Carcinoma of the Lower Back Skin: A Case Report and Review of the Literature

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