Pigmented Median Raphe Cysts of the Penis

Urahashi, Junko; Hara, Hiroyuki; Yamaguchi, Z; Morishima, Takafumi

doi:10.1080/000155500750012225

Cited by 35 publications

(5 citation statements)

References 9 publications

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“…Some authors attribute ciliated cysts to an additional abnormality of embryological development [47], whereas others refer to it as a result of metaplastic changes in the urothelium [58]. In our extensive literature search, we could only find three cases of pigmented variant [10, 46, 50], which in our view makes them truly rare.…”

Section: Discussion and Reviewmentioning

confidence: 90%

“…The cyst is generally solitary [3–5], sometimes double [3], and rarely presents as a chain of cystic swellings along the median raphe [4, 10, 33, 39]. The chain of cysts gives a cordlike appearance and has been described as canaliform MRCs [17, 29, 40].…”

Section: Discussion and Reviewmentioning

confidence: 99%

“…The cyst may have a bluish hue [6], which is more a characteristic of cystadenoma/hydrocystoma of the penis. Pigmented cysts appearing as brown-black in color due to presence of melanocytes and melanin pigment in the epithelial lining have also been reported [10, 46, 50]. Multiple areas are rarely involved.…”

Section: Discussion and Reviewmentioning

confidence: 99%

“…The ciliated type is characterized by the presence of ciliated cells interspersed with pseudostratified [16, 26, 47, 56] or columnar [31, 57, 58] epithelium. The pigmented variant appears brown-black in color due to the presence of melanocytes and melanin pigment in the epithelial lining [10, 46, 50]. Pigment granules can become evident with Fontana-Masson stain [50].…”

Section: Discussion and Reviewmentioning

confidence: 99%

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Median raphe cyst of the penis: a case report and review of the literature

2019

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Background A defect in embryological development or closure of median raphe may lead to formation of cyst(s) anywhere in the midline from glans to anus. These cysts are referred to as median raphe cysts, an uncommonly encountered clinical condition. The cyst is generally solitary, with the penile shaft being the most common location, with average size of around 1 cm. The diagnosis is mostly clinical and confirmed histologically. We report a case of a patient with a rare histological variant of median raphe cyst and provide a focused review on presentation, histopathology, and management. Case presentation A 29-year-old unmarried Nepali man presented to our clinic with an asymptomatic, solitary, soft, translucent, nontender cystic lesion of about 1-cm diameter at the ventral aspect of glans penis, close to the meatus, that had been noticed at the age of 3 and was nonprogressive for the past 15 years. Ultrasonography demonstrated an isoechoic cystic lesion at the tip of the penis, separated from the urethra, and lying entirely within the mucosa without any evidence of solid component, septation, or vascularity. On the basis of clinical and ultrasonographic findings, a diagnosis of median raphe cyst of the penis was made. The cyst was excised with the patient under local anesthesia, and there was no evidence of recurrence in 2 years of follow-up. The histopathological examination with Hematoxylin and eosin staining showed the cyst wall was lined partly by ciliated pseudostratified columnar epithelium and partly by columnar epithelium with apical mucin. Conclusions Median raphe cyst is an uncommon, mostly asymptomatic condition in young patients. The cyst may occur anywhere along the midline from glans to anus. The diagnosis is clinical with histological confirmation. Excision is the treatment of choice with minimal chance of recurrence.

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Section: Discussion and Reviewmentioning

confidence: 90%

Section: Discussion and Reviewmentioning

confidence: 99%

Section: Discussion and Reviewmentioning

confidence: 99%

Section: Discussion and Reviewmentioning

confidence: 99%

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Median raphe cyst of the penis: a case report and review of the literature

2019

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“…The third theory, hypothesized by Paslin, is an anomalous sprouting and subsequent separation of the urethral columnar epithelium from the urethra. [3]…”

Section: Discussionmentioning

confidence: 99%

Median raphe cyst of the penis: A startling diagnosis for the unaccustomed clinician

2019

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Penile median raphe cysts are uncommon lesions occurring predominantly in the ventral aspect of the glans penis of young men. In most patients, the cysts, which are asymptomatic or unrecognized during childhood, may progress later and become symptomatic during adolescence or adulthood. A differential diagnosis must be made from other penile skin lesions such as glomus tumors, dermoid cysts, pilonidal cysts, epidermal inclusion cysts, urethral diverticula, and steatocystomas that originate in the genital region. The usual treatment is complete surgical excision. We are presenting a case of a penile median raphe cyst which presented in a middle-aged adult.

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