Pigmented Nail Disorders

André, Josette; Lateur, Nadine

doi:10.1016/j.det.2006.03.012

Cited by 112 publications

(138 citation statements)

References 35 publications

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“…The etiologies of LM can be divided into 2 broad categories: melanocytic activation and melanocytic proliferation [2]. Although melanocytic activation is the most common cause of LM in pigmented individuals who frequently have benign racial melanonychia involving multiple digits [2][3][4], melanocytic proliferation raises more concerns because LM may indicate an early stage of nail apparatus melanoma. The differential diagnosis to tell whether melanoma is the causative factor of LM remains an important task for dermatologists [5].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Melanonychia: Differences in Etiology Are Associated with Patient Age at Diagnosis

Tseng¹,

Liang²,

Liau³

et al. 2017

Dermatology

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Background: Longitudinal melanonychia (LM) may occur as a result of nail apparatus melanoma. Knowledge of etiology plays an important role in the management of LM. Objectives: The study is aimed to compare the diagnosis of LM in different age groups. Methods: We collected 63 cases (45 adults and 18 children) with LM who underwent nail matrix biopsy or excision in a 21-year cohort and assessed their clinicopathological features. Results: Melanomas in adults and children were 40% and none, while nevi accounted for 15.6% in adults and 94.4% in children. There was a statistically significant difference between the average age at diagnosis for melanoma (54.5 ± 13.3 years) and nevus (15.2 ± 18.5 years). Logistic regression related the occurrence of melanoma to older ages with a relative risk of 1.2 compared to nevus, but no cutoffs between age groups could be deﬁned between LM-associated nevus and melanoma. Conclusion: The adult group has a significantly higher risk of melanoma, while children with LM show mostly nonmelanoma etiologies. Tissue proof is more warranted in adult cases, and it is needed in selected cases of children with LM.

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Section: Introductionmentioning

confidence: 99%

Longitudinal Melanonychia: Differences in Etiology Are Associated with Patient Age at Diagnosis

Tseng¹,

Liang²,

Liau³

et al. 2017

Dermatology

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“…They have a predilection for the thumb, and their size averages more than 3 mm in 50% of the cases. Their brownish-black color is present in two thirds of the cases, and periungual pigmentation (pseudo-Hutchinson's sign) is observed in one third of the cases [4]. Pseudo-Hutchinson's sign is the apparent pigmentation of the proximal nail fold seen through the transparent cuticle [2] and can be subdivided into three categories: benign, malignant nonmelanoma, and illusory.…”

Section: Discussionmentioning

confidence: 99%

“…Malignant nonmelanoma conditions, such as Bowen's disease, can also manifest in the same fashion. Finally, illusory pigmentation of the cuticle occurs when pigmentation is seen in the nail matrix or bed [4]. It is essential that subungual melanoma be ruled out, as both benign and malignant lesions can manifest as a linear pigmented band along the nail plate [4].…”

Section: Discussionmentioning

confidence: 99%

“…Finally, illusory pigmentation of the cuticle occurs when pigmentation is seen in the nail matrix or bed [4]. It is essential that subungual melanoma be ruled out, as both benign and malignant lesions can manifest as a linear pigmented band along the nail plate [4]. Clinical findings suggestive of malignant lesions include irregular pigmentation, color variegation, and bands that have a late development [2].…”

Section: Discussionmentioning

confidence: 99%

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Atypical Location and Morphology of a Proximal Nail Fold Nevus Mimicking Other Diseases

Minotto¹,

Giustina²,

Damiani³

et al. 2016

Skin Appendage Disord

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Melanocytic nevi result from the proliferation of melanocytes at the dermal-epidermal junction and/or in the dermis and very rarely affect the nail matrix and bed. Intradermal nevi are tumors often diagnosed in routine clinical dermatological practice, with typical clinical and histopathologic aspects, and found in a wide variety of skin sites. We report a case of intradermal melanocytic nevus of the proximal nail fold with uncommon intraoperative gross findings and without involvement of the nail bed or matrix, showing intradermal component only, which draws our attention to the possible different presentation of melanocytic lesions. No description of intradermal nevi at this site has been reported in the literature so far.

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“…1,2 Understanding the nail unit's anatomy and physiology is required for appropriate evaluation of this extensive differential diagnosis.…”

mentioning

confidence: 99%

Longitudinal Melonychia: Clinical Evaluation and Biopsy Technique

O’Connor

Dzwierzynski

2011

The Journal of Hand Surgery

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Pigmented Nail Disorders

Cited by 112 publications

References 35 publications

Longitudinal Melanonychia: Differences in Etiology Are Associated with Patient Age at Diagnosis

Longitudinal Melanonychia: Differences in Etiology Are Associated with Patient Age at Diagnosis

Atypical Location and Morphology of a Proximal Nail Fold Nevus Mimicking Other Diseases

Longitudinal Melonychia: Clinical Evaluation and Biopsy Technique

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