Pigmented onychopapilloma in Caucasians: a case series of six patients

Starace, Michela; Ferrari, Tiziano; Pezzetta, Serena; Savoia, Francesco; Zengarini, Corrado; Piraccini, Bianca Maria; Alessandrini, Aurora

doi:10.1111/ijd.15375

Cited by 8 publications

(8 citation statements)

References 4 publications

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“…It was first described by Baran and Perrin in 1995, 3 with a series of four patients who presented with the typical clinical appearance of longitudinal erythronychia. Since then, approximately 20 reports, describing a total of 205 cases, have been published on this diagnosis [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] (see Table 2). Atypical appearances, including longitudinal melanonychia, have been further described, especially in patients with pigmented skin.…”

Section: Discussionmentioning

confidence: 99%

“…3 Subsequent reports have described diverse presentations, including longitudinal melanonychia, longitudinal leukonychia, yellow-brown chromonychia, splinter hemorrhages, distal nail plate fissuring, and onycholysis. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] It could easily mimic worrisome diagnoses, including melanoma and squamous cell carcinoma. Misdiagnosis could cause significant patient distress and anxiety.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and onychoscopic features of histopathologically proven onychopapillomas and literature update

et al. 2021

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Background: Onychopapilloma is a benign tumor of the distal nail matrix and proximal nail bed with heterogeneous clinical presentations. It poses a diagnostic challenge because it could mimic subungual malignancies and inflammatory conditions. Clinical, onychoscopic, and histopathological clues play critical roles in diagnosis.Methods: We performed a retrospective chart review of onychopapilloma cases collected over 10 years, and characterized the clinical, onychoscopic, and histopathological features of onychopapilloma at an academic institution.Results: We obtained 17 biopsy-confirmed cases of onychopapilloma. Among our cases, we found manifestation of onychopapilloma as longitudinal erythronychia, longitudinal leukonychia, yellow-brown chromonychia, and longitudinal melanonychia.Long longitudinal or short splinter hemorrhages may be present. Distal fissuring with V-shaped notch, subungual keratotic mass, and onycholysis are other discernable features. Histopathological features include papillomatosis, epidermal hyperplasia, acanthosis of the distal nail bed, premature keratinization, matrix metaplasia, hyperkeratosis, and splinter hemorrhages; histopathological signs of malignancy were not observed in any of our cases.Conclusions: Onychopapilloma has polymorphic clinical and morphological features.Onychoscopic and histopathological studies are important to help exclude malignant mimickers. Consider onychopapilloma in the differential diagnoses of a monodactylous longitudinal streak in the nail, especially on the left thumb of an adult female.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical and onychoscopic features of histopathologically proven onychopapillomas and literature update

et al. 2021

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“…27 It generally presents as a reddish streak in the central portion of the nail plate, but may also present as longitudinal leukonychia or melanonychia. 28,29 Dermatoscopy typically shows a band of longitudinal erythronychia, often with distal onycholysis and prominent distal hyperkeratosis, 30 best seen when examining the free edge of the nail plate (Figure 14). Presence of a hyperkeratotic tip, absence of oozing and warty nail bed changes, and absence of pain are helpful signs and symptoms that make Bowen disease and squamous cell carcinoma less likely.…”

Section: Onychopapilloma Clinical and Dermatoscopic Signsmentioning

confidence: 99%

Diagnosis and surgical treatment of benign nail unit tumors

Starace

Rubin

Chiacchio

et al. 2023

J Deutsche Derma Gesell

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Summary Little is known about benign non‐melanocytic nail tumors, probably due to their low pathogenicity. They are commonly misdiagnosed as inflammatory or infective diseases. They have various features, depending on the type of tumor and its location in the nail apparatus. The typical sign of a tumor is the presence of a mass and/or secondary nail changes from damaged nail structures. In particular, if a single digit is affected by a dystrophic sign or a symptom is reported without any explanation, the presence of a tumor should always be ruled out. Dermatoscopy helps to enhance visualization of the condition and in many cases supports the diagnosis. It may also assist in identifying the right place to biopsy, but it never replaces surgery. Most common non‐melanocytic nail tumors are analyzed in this paper, including glomus tumor, exostosis, myxoid pseudocyst, acquired fibrokeratoma, onychopapilloma, onychomatricoma, superficial acral fibromyxoma and subungual keratoacanthoma. The aim of our study is to review the main clinical and dermatoscopic characteristics of the most common benign non‐melanocytic nail tumors, to correlate them with the histopathology and to advise practitioners of the best surgical management.

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“…Es ist in der Regel leicht onycholytisch und weist manchmal eine distale Kerbe und Splitterblutungen auf 27 . Im Allgemeinen präsentiert es sich als rötlicher Streifen im zentralen Teil der Nagelplatte, es kann jedoch auch als longitudinale Leukonychie oder Melanonychie auftreten 28,29 . In der Dermatoskopie zeigt sich normalerweise ein Streifen einer longitudinalen Erythronychie, oft mit einer distalen Onycholyse und einer deutlichen distalen Hyperkeratose 30 , die bei Untersuchung des freien Rands der Nagelplatte am besten erkennbar ist (Abbildung 14).…”

Section: Onychopapillomunclassified

“…Subunguale Exostose: (a) präoperative Bilder; (b) Bestätigung im Röntgen-Bild; (c) chirurgische Exzision; (d) 2 Jahre nach dem Eingriff. A B B I L D U N G 8 (a) Klinische und (b) onychoskopische Bilder einer myxoiden Pseudozyste.präsentiert es sich als rötlicher Streifen im zentralen Teil der Nagelplatte, es kann jedoch auch als longitudinale Leukonychie oder Melanonychie auftreten 28,29. In der Dermatoskopie zeigt sich normalerweise ein Streifen einer longitudinalen Erythronychie, oft mit einer distalen Onycholyse und einer deutlichen distalen Hyperkeratose30 , die bei Untersuchung des freien Rands der Nagelplatte am besten erkennbar ist (Abbildung 14).…”

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Diagnose und chirurgische Behandlung gutartiger Tumoren der Nägel

Starace

Rubin

Chiacchio

et al. 2023

J Deutsche Derma Gesell

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ZusammenfassungEs ist wenig über gutartige nicht-melanozytäre Nageltumoren bekannt. Grund dafür ist wahrscheinlich ihre niedrige Pathogenität. Sie werden häufig als entzündliche oder infektiöse Erkrankungen fehldiagnostiziert. Je nach Art des Tumors und seiner Lokalisation im Nagelapparat haben sie verschiedene Merkmale. Typische Zeichen eines Tumors sind eine Raumforderung und/oder sekundäre Nagelveränderungen, die aus den beschädigten Nagelstrukturen hervorgehen. Insbesondere wenn ein einziger Finger oder eine einzige Zehe Dystrophie aufweist oder ein Symptom ohne weitere Erklärung genannt wird, ist das Vorliegen eines Tumors immer auszuschließen. Eine dermatoskopische Untersuchung kann die Visualisierung der Erkrankung verbessern und unterstützt in vielen Fällen die Diagnose. Sie kann auch bei der Identifizierung der richtigen Stelle für eine Biopsie helfen, aber einen chirurgischen Eingriff nicht ersetzen.In diesem Artikel werden die häufigsten nicht-melanozytären Tumoren analysiert, einschließlich Glomustumor, Exostose, myxoide Pseudozyste, erworbenes Fibrokeratom, Onychopapillom, Onychomatrikom, superfizielles akrales Fibromyxom und subunguales Keratoakanthom.Ziel unserer Studie ist es, die wesentlichen klinischen und dermatoskopischen Eigenschaften der häufigsten gutartigen nicht-melanozytären Nageltumoren zu überprüfen und mit der Histopathologie zu korrelieren sowie Ärzte hinsichtlich der besten chirurgischen Versorgung zu beraten. SummaryLittle is known about benign non-melanocytic nail tumors, probably due to their low pathogenicity. They are commonly misdiagnosed as inflammatory or infective diseases. They have various features, depending on the type of tumor and its location in the nail apparatus. The typical sign of a tumor is the presence of a mass and/or secondary nail changes from damaged nail structures. In particular, if a single digit is affected by a dystrophic sign or a symptom is reported without any explanation, the presence of a tumor should always be ruled out. Dermatoscopy helps to enhance visualization of the condition and in many cases supports

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Pigmented onychopapilloma in Caucasians: a case series of six patients

Cited by 8 publications

References 4 publications

Clinical and onychoscopic features of histopathologically proven onychopapillomas and literature update

Clinical and onychoscopic features of histopathologically proven onychopapillomas and literature update

Diagnosis and surgical treatment of benign nail unit tumors

Diagnose und chirurgische Behandlung gutartiger Tumoren der Nägel

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