Pigmented purpura masquerading as acral melanoma

Callaghan, Grainne; Woods, Graham; Menzies, Stephanie; Moloney, Fergal J.

doi:10.1111/ajd.12885

Cited by 1 publication

(2 citation statements)

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“…We identified 17 cases of PPD with hand involvement in the literature (Table 2). 8,11–21 Again, a wide age range was found (5–73 years; mean, 33 years). There was a male predominance (male-to-female ratio, 2.4:1).…”

Section: Resultsmentioning

confidence: 99%

“…Although all of our cases were confined to the dorsum of one hand, most of the reported cases in the literature involved more than one site, and most frequently the proximal ipsilateral extremity. 8,11–21 Only 3 of the 17 previous cases were confined to one hand. 11,12,19 Clinical diagnosis of PPD is presumably easier to achieve when multiple sites are involved.…”

Section: Discussionmentioning

confidence: 99%

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Pigmented Purpuric Dermatosis of the Hand: Clinicopathologic Analysis of Six Cases With Review of the Literature

Runge

Nakamura²,

Sullivan³

et al. 2022

The American Journal of Dermatopathology

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Pigmented purpuric dermatosis (PPD) is a group of skin disorders characterized by red, brown, or golden macules and patches with cayenne pepper-like spots. Classic histopathologic features include a perivascular lymphocytic infiltrate with associated erythrocyte extravasation and hemosiderin deposition. Although PPD most commonly affects the lower extremities, upper extremity involvement has been infrequently reported. Cases involving the hands are particularly rare. We present 6 new cases of PPD involving the hand and review 17 previously reported cases in the literature. All cases in our series were unilateral and localized to the dorsum of the hand. PPD was considered clinically in only 2 of these cases. Histopathologic examination revealed hallmark features of PPD, namely a superficial perivascular lymphocytic infiltrate and extravasated erythrocytes. Previous reports of PPD involving the hand described concurrent involvement of other anatomic sites in most cases; only 4 cases (24%) were confined to the hands. Histopathologic descriptions of these reported cases were compatible with PPD. In sum, our series describes a unique and rare clinical presentation of PPD confined to the unilateral dorsal hand. Because of the unusual presentation, biopsy is often required for accurate diagnosis.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%