Pigmented purpuric dermatosis due to pseudoephedrine

Díaz‐Jara, M.; Tornero, Pilar; Barrio, M. De; Vicente, M. E.; Fuentes, Vanessa; Barranco, Ruth

doi:10.1034/j.1600-0536.2002.460511.x

Cited by 18 publications

(7 citation statements)

References 15 publications

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“…While gravity and venous insufficiency are important localizing factors in many cases, 1 various medications and chemical agents, including carbromal and meprobamate, 2,3 vitamin B1, 4 topical fluorouracil, 5 nitroglycerin, furosemide, chlordiazepoxide, and trichlomethianzole, 6 tartrazine, 7 glipizide, 8 medroxyprogesterone acetate, 9 and interferon 10 have been implicated as factors responsible for the development of pigmented purpuric dermatosis. An exogenous contact dermatitis, especially with textile dye, may play a possible role in some cases of the itchy purpuric type 11–13 . Furthermore, pigmented purpuric dermatosis lesions appear to be provoked by remote bacterial infection, such as odontogenic infection 14 .…”

Section: Discussionmentioning

confidence: 99%

“…An exogenous contact dermatitis, especially with textile dye, may play a possible role in some cases of the itchy purpuric type. [11][12][13] Furthermore, pigmented purpuric dermatosis lesions appear to be provoked by remote bacterial infection, such as odontogenic infection. 14 Delayed-type hypersensitivity or immunocomplex vasculitis has been considered as a possible mechanism in the pathogenesis of the disease.…”

Section: Discussionmentioning

confidence: 99%

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Pigmented purpuric dermatosis and hepatitis profile: a report on 10 patients

Dessoukey¹,

Abdel‐Dayem²,

Omar³

et al. 2005

Int J Dermatology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pigmented purpuric dermatosis and hepatitis profile: a report on 10 patients

Dessoukey¹,

Abdel‐Dayem²,

Omar³

et al. 2005

Int J Dermatology

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“…Pigmented purpuric dermatoses (PPDs) comprise asymptomatic to mildly pruritic pigmented lesions, with distinct clinical and histological findings 6. Although the aetiopathogenesis is unknown, steroids, antihistaminics, griseofulvin, ciclosporin, systemic steroids, psoralens, carbromal, carbutamide, meprobamate, glipizide, acetaminophen, zomepirac sodium, interferon α, diuretics, chlordiazepoxide and aminoglutethimide are implicated in a minority of cases 3 7 – 9.…”

Section: Predominantly Perivascular Dermatitismentioning

confidence: 99%

Drug-induced cutaneous pathology

Ramdial¹,

Naidoo²

2009

J Clin Pathol

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Drug-induced cutaneous rashes, whether confined to the skin or part of a systemic disease, are characterised by a spectrum of inflammatory disease patterns that include perivascular dermatitis, nodular and diffuse dermatitis, vesiculobullous lesions, pustular eruptions, sclerodermoid reactions, vasculitis, folliculitis/perifolliculitis and panniculitis. While a single drug can elicit a range of reaction patterns, no reaction pattern is specific for a particular drug. Although the temporal link between initiation of drug therapy and the onset of the drug rash is critical to the diagnosis, drug reactions may also occur during the course of chronic drug ingestion. Clues to the drug-induced nature of the cutaneous eruption include the presence of overlapping histological reaction patterns and incongruent clinical and histopathological features. While eosinophils are an important tell-tale sign of a drug-induced reaction, they may also be conspicuous in skin rashes devoid of a drug association. Furthermore, eosinophils may be sparse or absent in some drug exanthems. Heightened awareness of the mimicry of a wide spectrum of cutaneous pathology by an ever-increasing range of therapeutic agents is pivotal to the diagnosis of drug-induced skin pathology.

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“…The specific mechanism of non‐immediate reactions to epinephrine remains unknown. However, previous publications have shown that patch testing can provide the diagnosis of T lymphocyte‐mediated hypersensitivity caused by this pharmacological group as well as support cross‐sensitivity evidence . Pharmacological interaction has also been hypothesized in non‐immediate reactions to drugs .…”

Section: Discussionmentioning

confidence: 92%

“…However, previous publications have shown that patch testing can provide the diagnosis of T lymphocyte-mediated hypersensitivity caused by this pharmacological group as well as support cross-sensitivity evidence. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Pharmacological interaction has also been hypothesized in non-immediate reactions to drugs. 21 In recent years, evidence has become stronger that not all drugs need to bind covalently to the major histocompatibility complex (MHC)-peptide complex in order to trigger an immune response.…”

Section: Case Reportmentioning

confidence: 99%