Pigmented Squamous Cell Carcinoma

Satter, Elizabeth K.

doi:10.1097/dad.0b013e318156d756

Cited by 54 publications

(44 citation statements)

References 23 publications

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“…6,9,10,11 The dark hue of the tumor is due to scattered melanocytes in the tumor, abnormal thickening of the epidermis, and scattered hemorrhages. 19,20 Contrary to the common belief, most of the pigmented skin lesions (93%) in this study were benign and no case of malignant melanoma was encountered. Melanocytic nevi (73%) were the most common excised pigmented skin lesions and weremost often seen in females.…”

contrasting

confidence: 40%

Common Pigmented Skin Lesions

Khan¹,

Asghar²,

Akhund³

et al. 2018

TPMJ

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ABSTRACT… Objectives: The purpose of this study is; firstly, to study the histopathological spectrum of the pigmented skin lesions in the community, to signify that not all pigmented skin lesions are malignant melanomas; secondly, to assess the age-wise distribution of the common pigmented skin lesions; and thirdly, to determine the commonly affected body sites by these pigmented skin lesions. Study Design: Retrospective/Observational study. Setting: Charsada Teaching Hospital affiliated with Jinnah Medical College Peshawar. Period: 100 consecutive cases with clinical diagnosis of pigmented skin lesion, starting in the year 2013. Methods: In this study, 100 consecutive surgical pathology cases with clinical diagnosis of pigmented skin lesion were retrieved from the archives of Charsada Teaching Hospital affiliated with Jinnah Medical College Peshawar. All the specimens were incisional biopsies of skin, fixed in 10% formalin, embedded in paraffin, and stained with Hematoxylin and Eosin stains. Results: On analyzing 100 consecutive pigmented skin lesions (n=100) starting from the year 2013, it was found thatthe large majority of these lesions were benign. The most common pigmented skin lesion was melanocytic nevus. Moreover, majority of pigmented skin lesions were seen in females. Seborrheic keratosis and malignant tumors, like basal cell carcinoma and squamous cell carcinomas, were more commonly seen in males in the 6 th and 7 th decades of life; whereas, dermatofibroma and post-inflammatory pigmentation were more common in females in the 4 th and 5 th decades of life. Overall, the pigmented skin lesions were more common in the 3 rd , 4 th , and 5 th decades of life with peak in the 4 th decade. Skin of face was the most common site affected by melanocytic nevi and malignant epidermal skin tumors. Conclusions: In conclusion, most of the pigmented skin lesions are benign, encountered in the 4 th decade of life, and commonly affect the skin of face. Also, most of the melanocytic nevi are encountered in females, while most of the malignant epidermal neoplasms are encountered in males affecting the skin of face.

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contrasting

confidence: 40%

Common Pigmented Skin Lesions

Khan¹,

Asghar²,

Akhund³

et al. 2018

TPMJ

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“…11 It is hypothesized that the presence of nonneoplastic dendritic melanocytes are due to tumor colonization by normal melanocytes or through neoplastic multidirectional differentiation. 12,13 Although focal melanocytic hyperplasia along the epidermal basal layer overlying various neoplasms is not an uncommon phenomenon, colonization differs because there is a distinct population of individual dendritic melanocytes that are randomly dispersed throughout the entire neoplasm. 12 Melanocytic colonization is also observed in some breast cancers.…”

Section: Discussionmentioning

confidence: 99%

“…12,13 Although focal melanocytic hyperplasia along the epidermal basal layer overlying various neoplasms is not an uncommon phenomenon, colonization differs because there is a distinct population of individual dendritic melanocytes that are randomly dispersed throughout the entire neoplasm. 12 Melanocytic colonization is also observed in some breast cancers. It seems that the melanocytes exhibit a symbiotic relationship with the neoplastic cells, but it remains to be ascertained what promotes the melanocytes to proliferate and colonized the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…It seems that the melanocytes exhibit a symbiotic relationship with the neoplastic cells, but it remains to be ascertained what promotes the melanocytes to proliferate and colonized the tumor. 12 Porokeratosis is viewed as a neoplastic process that exhibits a link with carcinogenesis. This is proposed from the observation of the abnormalities in DNA ploidy shown by the inherited mutant clones of keratinocytes from porokeratotic skin lesions.…”

Section: Discussionmentioning

confidence: 99%

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Pigmented Porokeratosis. A Further Variant?

Tan

Tallon²

2016

The American Journal of Dermatopathology

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Porokeratosis is a clonal disorder of keratinization characterized by the presence of the cornoid lamella. A number of variants of porokeratosis have been described, based on the clinical features and histologic features of the lesions. The authors present a case of porokeratosis with prominent melanocytic hyperplasia, which was biopsied to clinically exclude melanoma. The authors retrospectively studied cases of porokeratosis to look for the presence of melanocytic hyperplasia. Melanocytic hyperplasia was identified in 8 of 31 cases (25.8%). All of the cases except the index case were clinically nonpigmented but arose in solar damaged skin. This case represents a distinct variant of porokeratosis, and the authors propose the designation pigmented porokeratosis. Melanocytic hyperplasia is a benign condition, and it is important that this is not histologically confused with melanoma in situ, particularly in a context of clinically pigmented lesion. Increased recognition of pigmented porokeratosis is essential to avoid an erroneous diagnosis of melanoma in situ.

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“…5,14 The prognosis of squamous neoplasms in patients with EV compared to patients without EV is unclear due to limited studies and clinical follow-up. Although the prevailing concept is that the clinical behavior of squamous cell carcinomas and Bowen disease in patients with EV is comparable to that of patients without EV, 15,16 other studies report squamous cell carcinoma tumors of patients with EV as aggressive and invasive.…”

Section: Discussionmentioning

confidence: 99%

Subungual Bowen Disease in a Patient With Epidermodysplasia Verruciformis Presenting Clinically as Longitudinal Melanonychia

Stetsenko

McFarlane

Chien

et al. 2008

The American Journal of Dermatopathology

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Epidermodysplasia verruciformis (EV) is a rare autosomal-recessive condition associated with a predisposition to infection with specific types of human papillomaviruses. A spectrum of wart-like lesions on the face, dorsa of the hands, and legs are characteristic clinical findings. Lesions usually develop in early childhood, persist, and may eventuate in cutaneous squamous cell carcinoma, usually in sun-exposed areas. These lesions are locally destructive and sometimes metastasize. We present a case of a 34-year-old African American woman with EV with a 9-month history of a right index finger ungual longitudinal pigmented band and nail splitting. Biopsy showed hyperkeratotic and parakeratotic subungual epithelium with verrucous hyperplasia. The superficial keratinocytes showed koilocytic changes. In addition, there was extensive, focally full-thickness keratinocyte dysmaturation with variable nuclear atypia and numerous mitotic figures, without apparent invasion. An associated melanocytic hyperplasia (confirmed by Melan-A stain), composed of large, pigment-laden dendritic melanocytes, was present without appreciable atypia or pagetoid spread. The findings are of a squamous cell carcinoma in situ arising in association with EV with incidental melanocytic hyperplasia. To the best of our knowledge, this is first report of a subungual presentation of this condition with associated melanonychia.

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Pigmented Squamous Cell Carcinoma

Cited by 54 publications

References 23 publications

Common Pigmented Skin Lesions

Common Pigmented Skin Lesions

Pigmented Porokeratosis. A Further Variant?

Subungual Bowen Disease in a Patient With Epidermodysplasia Verruciformis Presenting Clinically as Longitudinal Melanonychia

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