Pigmented villonodular synovitis

Sirlyn, Quanson

doi:10.1002/sono.12003

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…They are most common in the middle and index fingers occurring twice as frequently in the volar than the dorsal aspect of the hand. They represent the most common space‐occupying lesion of the hand secondary to ganglia …”

Section: Flexor Tendons – Open or Closed Injuriesmentioning

confidence: 99%

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Ultrasound of flexor digitorum apparatus in acute and chronic pathology

Sirlyn¹,

Bird²

2018

Sonography

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The flexor digitorum apparatus (FDA) of the finger consists of two flexor tendons located within their osteofibrous tunnel, reinforced by the pulley apparatus and the supporting volar plates. The FDA is essential for facilitating hand grasping functions, and pathology affecting the FDA can result in functional impairment of the hand. These injuries can be open or closed in nature and are commonly the sequelae of acute trauma or chronic overuse. This article includes an overview of the anatomy of the FDA, ultrasound scanning technique and common pathologies that sonographic assessment may encounter. The anatomy of the finger and its variants is complex, and an ultrasound can only be accurate if the operator possesses comprehensive knowledge of these structures.Funding: None. Conflict of interest: None.Sonography 5 104-114

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Section: Flexor Tendons – Open or Closed Injuriesmentioning

confidence: 99%

“…Dynamic ultrasound is able to demonstrate the relationship between the nodules and the adjacent tendon and tendon sheath. Pigmented villonodular tenosynovitis lesions arise from the tendon sheath and move independently to the tendon during dynamic assessment …”

Section: Flexor Tendons – Open or Closed Injuriesmentioning

confidence: 99%

Ultrasound of flexor digitorum apparatus in acute and chronic pathology

Sirlyn¹,

Bird²

2018

Sonography

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Anterior Ankle

Greenberg,

Day,

Alradawi

2023

Manual of Musculoskeletal Ultrasound

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Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis

Brahmi

Vinceneux

Cassier

2016

Curr. Treat. Options in Oncol.

103

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Adequate surgical resection remains the treatment of choice for tenosyovial giant cell tumor (TGCT). However, diffuse type TGCT (D-TGCT) is more difficult to resect and has a higher rate of recurrence (up to 50 %), which is often multiple. D-TGCT is rarely lethal and only rare cases of metastases have been described. Nevertheless, patients might have a significant decline in their quality of life due to multiple operations, which may sometimes result in a partial loss of function of the affected joint and may also be associated with perioperative morbidity and secondary arthrosis. As of today, no systemic treatment is approved for this rare disease. The aims of systemic therapy in the context of a non-lethal tumor are to reduce surgical morbidity and to preserve function and patient quality of life. Because TGCT is associated with characteristic cytogenetic abnormalities resulting in the overexpression of CSF1, systemic therapies targeting the CSF1/CSF1R axis (imatinib, nilotinib, emactuzumab, and PLX3397) have been tested in patients with locally advanced or relapsed D-TGCT. The more recent and more specific CSF1R inhibitors have shown a very interesting clinical activity with acceptable toxicity in early phase trials. These results will need to be confirmed in larger, ideally randomized, trials. But the high rate of clinical and functional improvement seen in some patients with advanced D-TGCT, often after multiple operations, suggests that these inhibitors will likely have a role in the management of patients with an inoperable disease; the definition of "inoperable TGCT" still requires refinement to reach a consensus. Another point that will need to be addressed is that of "the optimal duration of therapy" for these patients. Indeed, we and others have observed often prolonged clinical benefit and symptomatic relief even after treatment was stopped, with both monoclonal antibodies and tyrosine kinase inhibitors. Responses were observed very early on with emactuzumab and PLX3397, and patients experienced significant symptom improvement within a few weeks of starting therapy (2-4 weeks). Another possible application of CSF1R inhibitors could be used either as a preoperative or postoperative therapy for patients with operable TGCT. However, we currently lack sufficient follow-up to adequately address these questions which will each require specific trial designs. Overall, the striking clinical activity of CSF1R specific inhibitors in TGCT has created great enthusiasm among clinicians, and further development of these agents is clearly medically needed. Nevertheless, further investigations are necessary to validate those treatments and assess how to best incorporate them among other treatment modalities into the overall therapeutic strategy for a given patient.

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Pigmented villonodular synovitis

Cited by 5 publications

References 13 publications

Ultrasound of flexor digitorum apparatus in acute and chronic pathology

Ultrasound of flexor digitorum apparatus in acute and chronic pathology

Anterior Ankle

Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis

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