Pigmented villonodular synovitis (giant-cell tumor of the tendon sheath and synovial membrane). A review of eighty-one cases.

Rao, Addepalli Srinivasa; Vigorita, Vincent J.

doi:10.2106/00004623-198466010-00012

Cited by 395 publications

(214 citation statements)

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“…Some authors claim that the insignificant degree of inflammation, the nodular growth pattern, the propensity for recurrence after inadequate removal and the lack of characteristic changes in the adjacent synovial tissue suggest that PVNS is not an inflammatory synovitis. Moreover they argue that there does not seem to be a relationship between the degree of fibrosis and either the duration of symptoms or the size of the lesion, and no histological evidence of progressive fibrotic changes was seen [25].…”

Section: Discussionmentioning

confidence: 99%

Proliferating cell nuclear antigen labelling index in localised pigmented villo-nodular synovitis and its relationship to the size of nodules

Rosa

Galli

Fadda

et al. 2000

International Orthopaedics

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Proliferating cell nuclear antigen (PCNA) is one of the cell cycle-related proteins directly involved in DNA synthesis. It is a marker of cellular proliferation and has been shown to correlate with ploidy and proliferative activity of cells. Its expression has been used to estimate the growth fraction of human cancer and its prognostic value. Pigmented villo-nodular synovitis (PVNS) is characterised by a nodular lesion in the paratendinous synovial tissue or, less frequently, in a joint. Whether PVNS is a neoplastic or inflammatory lesion remains controversial. We have studied immunohistochemical PCNA expression with pc10 monoclonal antibody in 16 paraffin sections, in 16 cases of localised PVNS, or giant cell tumour of tendon sheath. We have found significant correlation between the size of the lesions and PCNA-LI (labelling index).Résumé L'antigène nucleaire de prolifération cellulaire (PCNA) est une des proteines du cycle cellulaire et il est impliqué directement dans la synthèse du DNA. Il s'agit certainement d'un indicateur de prolifération cellulaire. Son expression a été employé pour évaluer l'index de prolifération de la tumeur humaine et son valeur au point de vue pronostique. La synovite villo-nodulaire pigmentée (PVNS) est caractérisée par une lésion nodulaire plus fréquente dans les localisations tendineuses que dans les articulations. S'il s'agit d'un processus néoplasique ou d'une lésion inflammatoire reste controversée. Nous avons étudiés l'expression immunohistochimique du PCNA avec l'anticorps monoclonal PC10 en 16 lames paraffinés relatives à 16 synovites villo-nodulaires pigmentées localisées ou tumeurs à cellules geantes des gaines tendineuses. Nous avons trouvés une corrélation significative entre les dimensions des lésions nodulaires et le PCNA labelling index (PCNA-LI).

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Section: Discussionmentioning

confidence: 99%

Proliferating cell nuclear antigen labelling index in localised pigmented villo-nodular synovitis and its relationship to the size of nodules

Rosa

Galli

Fadda

et al. 2000

International Orthopaedics

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“…Recurrence of the illness after resection of the localized form is rare. 26,27 In the diffused form, the commonly suggested treatment is partial or extensive synovectomy. 4,5,10,21,23,24,27 The main problem appears to be the high rate of recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…29 Contrary to cases treated arthroscopically, complications such as pain and joint stiffness are frequently noted after open synovectomy. 21,28 We do not currently have direct experience using radiation therapy 26 in association with synovectomy to reduce the recurrence rate. 29 We can conclude that arthroscopic treatment has an efficacy similar to that with the open approach.…”

Section: Discussionmentioning

confidence: 99%

Result of arthroscopic treatment of pigmented villonodular synovitis of the knee

Ponti

Sansone

Malcherè

2003

Arthroscopy: The Journal of Arthroscopic & Related Surgery

138

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“…These patients generally present as painless swelling over hand, but when it affects other anatomical sites, it may be painful on presentation. 6 Ultrasonography of the mass is the primary diagnostic tool. GCTTS appears as a solid homogeneous hypoechoic mass on ultrasound exam.…”

Section: Discussionmentioning

confidence: 99%

Giant cell tumor of tendon sheath

et al. 2017

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Giant Cell Tumor of Tendon Sheath (GCTTS) is the second most common benign tumour affecting hand after ganglion. The tumor generally affects individuals between the age of 30 and 50 years, and is found more often in women than men. The etiological factors responsible for GCTTS are unclear. Some authors consider it as an inflammatory process arising as a consequence of chronic antigenic stimulation. Local excision with or without radiotherapy is the treatment of choice. We recently encountered two cases of Giant cell tumor involving tendon sheath of ring finger in one case and thumb in another case. Both were managed surgically with good results. There has been no evidence of recurrence till date in the follow up varying from 3-6 months.

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Pigmented villonodular synovitis (giant-cell tumor of the tendon sheath and synovial membrane). A review of eighty-one cases.

Cited by 395 publications

References 0 publications

Proliferating cell nuclear antigen labelling index in localised pigmented villo-nodular synovitis and its relationship to the size of nodules

Proliferating cell nuclear antigen labelling index in localised pigmented villo-nodular synovitis and its relationship to the size of nodules

Result of arthroscopic treatment of pigmented villonodular synovitis of the knee

Giant cell tumor of tendon sheath

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