Pigmented villonodular synovitis of a lumbar intervertebral facet joint

Müslüman, Ahmet Murat; Çavuşoğlu, Halit; Yılmaz, Adem; Dalkılıç, Türker; Tanık, Canan; Aydın, Yunus

doi:10.1016/j.spinee.2008.12.010

Cited by 14 publications

(18 citation statements)

References 22 publications

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“…It is similar with the rate of appendicular PVNS reported in different studies (0-50%)14,17,23,34). Various treatments for PVNS include surgery, radiation therapy, radioisotope infusions, and chemotherapy8,21,22,33,48). Surgical excision with the aim of gross total resection is accepted as the treatment of choice.…”

Section: Discussionmentioning

confidence: 99%

Pigmented Villonodular Synovitis on Lumbar Spine : A Case Report and Literature Review

Lee

Eoh

2014

J Korean Neurosurg Soc

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Pigmented villonodular synovitis (PVNS) is a benign proliferative joint disease with an uncertain etiology that uncommonly involves the spine. We present a case of PVNS involving the lumbar spine. A 38-year-old male developed back pain and pain in both legs caused by a mass in the L4 region of the right lamina. After gross total tumor removal, the symptoms improved. The pathological finding was synovial hyperplasia with accumulation of hemosiderin-laden macrophages. He was diagnosed with PVNS and experienced no recurrence for up to 2 years after surgery. In this report, we review the previous literature and discuss etiology, clinical manifestations, diagnosis, and treatment.

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Section: Discussionmentioning

confidence: 99%

Pigmented Villonodular Synovitis on Lumbar Spine : A Case Report and Literature Review

Lee

Eoh

2014

J Korean Neurosurg Soc

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“…It is characterized by synovial hyperplasia and pigment deposition (hemosiderin) inside the joints, tendon sheaths and bursae. Evidence shows that it mainly affects large joints such as the knee and the hip [ 2 , 3 ], and is extremely rare in the temporomandibular joint [ 4 ] and spine [ 5 ]. It mainly occurs between 20–40 years, though it is also found in children and the elderly.…”

Section: Introductionmentioning

confidence: 99%

Pigmented Villonodular Synovitis: A Retrospective Multicenter Study of 237 Cases

et al. 2015

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PurposeTo review clinical characteristics of pigmented villonodular synovitis (PVNS) in China.MethodsElectronic medical records (EMR) of four Chinese institutes were queried for patients with histologically proven PVNS between January 2005 and February 2014. Their data were collected including gender, age at diagnosis, clinical presentation, affected site, symptom duration, comorbidities, treatment strategy, recurrence and routine laboratories.ResultsA total of 237 patients with biopsy-proven PVNS were investigated. The gender ratio was 1.35 for a female predominance (101 males and 136 females). The average age was 36 years (range, 2 to 83 years). The median delay from initial clinical symptom to diagnosis was 18 months. Main affected areas were the knee (73.84%) and the hip (18.14%). Forty patients had a clear history of joint trauma. Six patients were concurrently diagnosed with PVNS and avascular necrosis (AVN). Five patients suffered from PVNS following implantation of orthopaedic devices including artificial prosthesis, plate and wire. One hundred and twenty-nine patients underwent arthroscopic synovectomy and 108 open synovectomy. Altogether 48 patients (26 males and 22 females) had recurrence of disease. The relapse rate was 24% (knee) and 6.98% (hip), 20.93% (open surgery) and 19.44% (arthroscopy), respectively. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) rate were elevated in 45.83% and 38.41% of the patients respectively.ConclusionsTo our knowledge, this study is the largest sample size of PVNS patients reported as well as the largest sample of PVNS with concurrent AVN reported to date. Our outcomes suggest that PVNS shows a female predominance, occurs mostly between 20–40 years and favors the knee and hip. Recurrence is frequent, particularly in the knee. Serum ESR and CRP may be elevated in some patients. Additionally, the present study supports the theory of an association between PVNS and orthopedic surgery, which is not limited to joint replacement.

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“…This investigation is also able to reveal the extent of the lesion, mainly any conflicts with nervous structures 17 . Nevertheless, radiologic diagnosis of PVNS is not obvious, and several differential diagnoses may be discussed including primary bone lesions, extradural and mesenchymal neoplasms such as osteoblastomas, schwannomas, large cell lymphomas, fibrohistiocytic tumors and hypertrophic synovitis 2,9,16 …”

Section: Discussionmentioning

confidence: 99%

Villonodular synovitis of the lumbar spine: Case report of a rare pathology

Gader

Belaïd

Zehani

et al. 2020

Clinical Case Reports

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Pigmented villonodular synovitis (PVNS) is a rare proliferative disorder of an uncertain origin belonging to benign synovial dystrophies, characterized by villous or nodular hyperplasia of the synovium. 1,2 There are mainly two types of PVNS: the first affects the synovium of a joint diffusely, whereas the second localized form focally involves the synovium about a tendon sheath. 1,3 The diffuse form is usually monoarticular, affecting large joints such as knees, hips, ankles, shoulders, and elbows. 1,4 But PVNS rarely involves the axial skeletal system. 5-7 Within the spine, lumbar localizations are the less encountered. Thus, their description in the literature is only restricted to some case reports. 1,7 In this paper, we report a new case of a PVNS of the lumbar spine and try to review different epidemiologic, clinic, radiologic, and therapeutic features related to this pathologic entity.

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Pigmented villonodular synovitis of a lumbar intervertebral facet joint

Cited by 14 publications

References 22 publications

Pigmented Villonodular Synovitis on Lumbar Spine : A Case Report and Literature Review

Pigmented Villonodular Synovitis on Lumbar Spine : A Case Report and Literature Review

Pigmented Villonodular Synovitis: A Retrospective Multicenter Study of 237 Cases

Villonodular synovitis of the lumbar spine: Case report of a rare pathology

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