Pigmented villonodular synovitis of the knee: A retrospective analysis of 214 cases at a UK tertiary referral centre

Does CSF1 overexpression or rearrangement influence biological behaviour in tenosynovial giant cell tumours of the knee?

“…According to the 2013 World Health Organisation (WHO) classification, TGCT is subdivided into a lobulated well circumscribed lesion (localised type) and a more locally aggressive lesion, involving a large part or all the synovial lining (diffuse type) (Figure ) . The standard choice of treatment was surgical resection of the lesional tissue, either arthroscopically or with an open resection . The localised‐type TGCT is known to have a favourable course after resection (average recurrence rates <6%), while the diffuse‐type TGCT generally causes significant morbidity due to the high risk of local recurrence (>50% depending on surgical procedure and follow‐up time) .…”

Arthroscopic Technique for the Treatment of Localized Pigmented Villonodular Synovitis of the Knee

“…The surgical treatment of LPVNS is generally accepted as either open or arthroscopic localized synovectomy, with no significant difference in recurrence [12]. A large retrospective analysis of 214 cases of knee PVNS, including 100 cases of LPVNS, concluded that there was no difference in local recurrence rates between open and arthroscopic treatment of LPVNS [13]. A review article comparing open with arthroscopic synovectomy for PVNS of the knee including both cases of diffuse PVNS and LPVNS concluded that there was no significant difference between the two in terms of rates of recurrence, complication, and osteoarthritis [14].…”

Tenosynovial Giant Cell Tumors in Children: A Similar Entity Compared With Adults

“…Nonspecific symptoms accompanied by pain and diffuse joint swelling with thickening of the synovial capsule and/or joint effusion resulted in limited movement in approximately half of the patients. Studies in adults add mechanical symptoms, instability, and stiffness [19,26].…”

“…A systematic review (without age limitations) in 2013 [26] reported average recurrence rates for localized TGCT in the knee after open resection (4%) and after arthroscopic resection (6%) in contrast to the diffuse type after open resection (14%) and after arthroscopic resection (40%) at a mean followup of 108 months. Patel et al [19] presented 214 patients with knee TGCT of all ages with a recurrence rate of 9% in 100 localized patients and 48% in 114 patients with diffuse TGCT after a mean followup of 25 months (range, 1-168 months). Palmerini et al [17] reported 294 patients with TGCT of all ages in all joints with a local failure rate of 14% in localized and 36% in diffuse type after a median followup of 4.4 years (range, 1-20 years).…”