PIK3CG single nucleotide polymorphisms are associated with poor responsiveness to clopidogrel and increased risk of ischemia in patients with coronary heart disease

Li, Kecheng; Yu, Shuling; Zhuge, Baozhong

doi:10.1097/md.0000000000007566

Cited by 6 publications

(2 citation statements)

References 42 publications

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“…PIK3CG protein belonged to the member protein of pI3/pI4-kinase and was an extracellular signaling critical modulator; including the cell-cell adhesion mediated by E-cadherin that importantly act proper maintenance with its integrity of structural epithelia [32] . In a combined meta-analysis of carotid plaques confirmed the rs17398575 SNP in PIK3CG gene that might induce an 18% chances plaque formation, showed PIK3CG had important clinical significance for higher chances of aggregation in platelet leading to acute coronary syndromes [33] . In our study, the results showed that PIK3CG were up-regulated in stable atherosclerotic plaques samples, compared with ruptured atherosclerotic plaques.…”

Section: Discussionmentioning

confidence: 97%

The ubiquitin-proteasome activity of macrophages involved in the rupture of atherosclerotic plaque based on bioinformatics analysis

Wan

Zhang

et al. 2020

Preprint

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Background Macrophages have been demonstrated to promote the rupture of the atherosclerotic lesion, a primary cause of ischemic events, by modulating the formation of plaque necrosis. We aimed to search the key factors of genetic macrophages in concerns of carotid ruptured plaques.Methods The database of the gene expressed GSE41571 is retrieved from the Gene Expression Omnibus (GEO) to differentially obtain the measured expression genes (DEGs) by tendering the tool usage of GEO2R. The enriched pathways of ontology at DEGs performances with DAVID interacted the constructions of protein to protein networking by the analysis of STRING and Cytoscape software. And also the identified PPI networks in the significance of hub genes module plugged into respective Cytohubba and MCODE Cytoscape.Result A total of 1481 DEGs in macrophages from ruptured and stable carotid atherosclerotic plaques are noticed, by including 568 up-regulation genes and 913 down-regulation genes. The analyzed GO shows a DEGs are mainly involved in protein ubiquitination, endocytosis, mRNA processing, and mitotic cell cycle. KEGG pathway enrichment analysis revealed that some major protein catabolism pathways, including the ubiquitin-proteasome, autophagy, and endocytosis systems, play key roles in the progressive carotid plaque clotting. The genes of the hub in the PPI network included POLR2E , PPP2R1A , HSP90AA1 , and CBL . The modules were mainly associated with ubiquitin-mediated proteolysis, endocytosis, spliceosome, proteasome.Conclusion Our findings offer novel molecular insights into the mechanisms by which macrophages drive formation and vulnerability of plaques. The candidate DEGs and potential biological pathways might be used as diagnostic targets, and facilitate the development of novel macrophage-targeting therapies for unstable atherosclerosis.

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Section: Discussionmentioning

confidence: 97%

The ubiquitin-proteasome activity of macrophages involved in the rupture of atherosclerotic plaque based on bioinformatics analysis

Wan

Zhang

et al. 2020

Preprint

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“…Rebrova et al ( 5 ) demonstrated that there was no association between the risk of clopidogrel resistance and the presence of polymorphic variants of platelet receptor genes P2RY12 and GpIII. However, Li et al ( 6 ) reported that a positive correlation might exist between PIK3CG SNPs (rs1129293 and rs17398575) and patients unresponsive to clopidogrel. In the present article, authors concluded that the presence of the CYP2C19*2 or *3 mutant allele was significantly associated with attenuated platelet response to clopidogrel and increased risk of clopidogrel resistance, although there was no obvious connection between presence of ABCB1 mutant allele and risk of clopidogrel resistance.…”

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confidence: 99%

Comment on “Association between CYP2C19 and ABCB1 polymorphisms and clopidogrel resistance in clopidogrel-treated Chinese patients

Wang

Lu²,

Wang³

et al. 2018

Anatol J Cardiol

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The identification of key genes in nasopharyngeal carcinoma by bioinformatics analysis of high-throughput data

Xiang

et al. 2019

Mol Biol Rep

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PIK3CG single nucleotide polymorphisms are associated with poor responsiveness to clopidogrel and increased risk of ischemia in patients with coronary heart disease

Abstract: A positive correlation may exist between PIK3CG SNPs (rs1129293 and rs17398575) and patients with poor responsiveness to clopidogrel. These findings show that this factor may contribute to an increased risk of ischemia in patients suffering from CHD.

Cited by 6 publications

References 42 publications

The ubiquitin-proteasome activity of macrophages involved in the rupture of atherosclerotic plaque based on bioinformatics analysis

The ubiquitin-proteasome activity of macrophages involved in the rupture of atherosclerotic plaque based on bioinformatics analysis

Comment on “Association between CYP2C19 and ABCB1 polymorphisms and clopidogrel resistance in clopidogrel-treated Chinese patients

The identification of key genes in nasopharyngeal carcinoma by bioinformatics analysis of high-throughput data

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