PIKE-A Modulates Mitochondrial Metabolism through Increasing SDHA Expression Mediated by STAT3/FTO Axis

Sun, Mingming; Yan, Qi; Qiao, Yaya; Zhao, Huifang; Wang, Yingzhi; Shan, Changliang; Zhang, Shuai

doi:10.3390/ijms231911304

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Bojie Chen et al 28 discovered that reversible mitochondrial inhibition might limit tumour growth, migration, and invasion via the PI3K/Akt/FoxO1/Cyclin D1 pathway for papillary thyroid cancer. Moreover, Mingming Sun et al discovered that PIKE-A (phosphoinositol 3-kinase enhancer activated Akt) influences the expression of respiratory chain complex II succinate dehydrogenase A (SDHA) via the STAT3/FTO axis, hence influencing mitochondrial activity 29 . In work by Jiao-Yan Cheng et al, AKT inhibitors substantially affected the location of PHB1 in mitochondria, which is essential for mitochondrial function 30 .…”

Section: Discussionmentioning

confidence: 99%

UQCRFS1 serves as a prognostic biomarker and promotes the progression of ovarian cancer

Sun

Dong

et al. 2023

Sci Rep

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UQCRFS1 has been reported to be highly expressed in gastric and breast cancer, but the mechanism remains unclear. The prognosis and biological functions of UQCRFS1 in ovarian cancer (OC) have not been evaluated. The expression of UQCRFS1 in EOC was detected by GEPIA and HPA websites, and the prognosis value was investigated by Kaplan–Meier analysis. Then the correlation between the UQCRFS1 gene and tumor-related signature were analyzed by Spearman correlation analysis and rank sum test. Subsequently, the expression of the UQCRFS1 gene in four ovarian cancer cell lines was detected. A2780 and OVCAR8 with the highest expression of UQCRFS1 were selected in the following biological experiments. Cell proliferation was detected by CCK8 assay, cell cycle and apoptosis were determined by flow cytometry, reactive oxygen species (ROS) production was detected by DCFH-DA, DNA damage gene mRNA expression was analyzed by RT-PCR, and AKT/mTOR pathway protein expression were also examined by western blot after siRNA transfection. We found that UQCRFS1 was high-expression in EOC and associated with poor prognosis. Spearman correlation analysis revealed that the high expression of UQCRFS1 is associated with the cell cycle, apoptosis, oxidative phosphorylation, and DNA damage. Further studies found that knockdown of UQCRFS1 cells reduced cell proliferation, cell cycle arrest at the G1 phase, increased proportion of apoptosis, ROS production, and expression of DNA damage genes, inhibited ATK/mTOR pathway. The study suggested that UQCRFS1 may be a candidated target for diagnosis and treatments in OC.

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Section: Discussionmentioning

confidence: 99%

UQCRFS1 serves as a prognostic biomarker and promotes the progression of ovarian cancer

Sun

Dong

et al. 2023

Sci Rep

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“…FTO, known for its role in fat consumption and overall metabolic rate regulation [ 136 ], also acts as a demethylase for m6A, affecting pre-mRNAs’ alternative splicing and 3′-end processing [ 137 ]. FTO’s influence extends to mitochondrial functions, affecting the expression of genes like SDHA and regulating the STAT3/FTO axis [ 138 ]. Prognostic studies suggest that FTO can predict poor outcomes in glioma patients, and inhibitors targeting FTO have shown promise in reducing tumorigenicity and aggressiveness in glioma models [ 139 , 140 , 141 , 142 ].…”

Section: Rna Modifications In Gliomamentioning

confidence: 99%

Emerging Roles and Mechanisms of RNA Modifications in Neurodegenerative Diseases and Glioma

Kobayashi,

Kitagawa,

Nasser

et al. 2024

Cells

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Despite a long history of research, neurodegenerative diseases and malignant brain tumor gliomas are both considered incurable, facing challenges in the development of treatments. Recent evidence suggests that RNA modifications, previously considered as static components of intracellular RNAs, are in fact dynamically regulated across various RNA species in cells and play a critical role in major biological processes in the nervous system. Innovations in next-generation sequencing have enabled the accurate detection of modifications on bases and sugars within various RNA molecules. These RNA modifications influence the stability and transportation of RNA, and crucially affect its translation. This review delves into existing knowledge on RNA modifications to offer a comprehensive inventory of these modifications across different RNA species. The detailed regulatory functions and roles of RNA modifications within the nervous system are discussed with a focus on neurodegenerative diseases and gliomas. This article presents a comprehensive overview of the fundamental mechanisms and emerging roles of RNA modifications in these diseases, which can facilitate the creation of innovative diagnostics and therapeutics for these conditions.

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Marine-derived antimicrobial peptide piscidin-1 triggers extrinsic and intrinsic apoptosis in oral squamous cell carcinoma through reactive oxygen species production and inhibits angiogenesis

Chiu,

Kuo,

et al. 2024

Free Radical Biology and Medicine

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PIKE-A Modulates Mitochondrial Metabolism through Increasing SDHA Expression Mediated by STAT3/FTO Axis

Cited by 4 publications

References 29 publications

UQCRFS1 serves as a prognostic biomarker and promotes the progression of ovarian cancer

UQCRFS1 serves as a prognostic biomarker and promotes the progression of ovarian cancer

Emerging Roles and Mechanisms of RNA Modifications in Neurodegenerative Diseases and Glioma

Marine-derived antimicrobial peptide piscidin-1 triggers extrinsic and intrinsic apoptosis in oral squamous cell carcinoma through reactive oxygen species production and inhibits angiogenesis

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