Pilomatricoma Arising at an Influenza Vaccination Site

Jeon, Heechang; Jeong, Seong Ho; Dhong, Eun Sang; Han, Seung Kyu

doi:10.5999/aps.2014.41.6.775

Cited by 7 publications

(12 citation statements)

References 5 publications

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“…Pilomatricoma, also known as calcifying epithelioma of Malherbe, is a benign calcifying tumor that arises from the hair matrix and presents as a slow-growing dermal or subcutaneous mass. 6 Pilomatricoma mainly occurs in children and adolescents. Another small onset peak is between the ages of 50 and 70 years.…”

Section: Discussionmentioning

confidence: 99%

Bullous Pilomatricoma After Influenza Vaccination

Zhang¹,

Jin²,

Chen³

et al. 2022

CCID

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Pilomatricoma, also known as “benign calcifying epithelioma”, is an uncommon slow-growing benign adnexal skin tumor, which originates from primitive cells of the hair matrix and usually appears as a solitary, firm, and asymptomatic nodule beneath the skin. Bullous pilomatricoma is a rare form of pilomatricoma, always presenting with firm subcutaneous nodules with a bullous appearance. In this study, we report a 9-year-old Chinese presenting girl with bullous pilomatricoma after influenza vaccination.

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Section: Discussionmentioning

confidence: 99%

Bullous Pilomatricoma After Influenza Vaccination

Zhang¹,

Jin²,

Chen³

et al. 2022

CCID

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“…A trauma that can damage the hair follicles during vaccination can also lead to missuppression in apoptosis and to pilomatricoma formation. 8 In our case, we, too, believe that the post-vaccination inflammation has triggered the formation of the tumor. Hematoma subsequent to an injection can also accelerate the growth of pilomatricoma tumors.…”

Section: Discussionmentioning

confidence: 54%

“…Tumors that arise after vaccination can be thought to be induced by traumas and persistent inflammation associated with the injection. 8 Pirouzmanesh et al 12 report that inflammation was seen in 40.8% of their pilomatricoma cases in microscopic examinations. A trauma that can damage the hair follicles during vaccination can also lead to missuppression in apoptosis and to pilomatricoma formation.…”

Section: Discussionmentioning

confidence: 97%

“…Prophylactic vaccines rarely cause skin complications. 8 Bullous pilomatricoma has been reported to develop after Hepatitis A vaccination in the injection site. 9 In the literature, there are several cases of pilomatricoma reported to occur in the injection site after a BCG vaccine, 10 an influenza vaccine 8 or following intramuscular injections 11 .…”

Section: Discussionmentioning

confidence: 99%

“…8 Bullous pilomatricoma has been reported to develop after Hepatitis A vaccination in the injection site. 9 In the literature, there are several cases of pilomatricoma reported to occur in the injection site after a BCG vaccine, 10 an influenza vaccine 8 or following intramuscular injections 11 . But we have not come across any reports about a pilomatricoma case that occurred following a combination vaccine (Measles-Mumps-Rubella [MMR], Pneumococcal Conjugate [PCV], and Chickenpox) administered at the age of 12 months.…”

Section: Discussionmentioning

confidence: 99%

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Pilomatricoma in the Upper Extremity after Vaccination: A Case Report

Tuzlali¹,

Kaya²,

Gültan³

2017

Turk J Plast Surg

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Pilomatricoma (also known as pilomatrixoma) is a rare benign skin tumor arising from hair follicle stem cells; it is also known as calcifying epithelioma of Malherbe. A definitive diagnosis can be made by histopathological examination. Surgical excision of the lesion is recommended for its treatment. The lesion can often be misdiagnosed when differential has not been considered. In the literature, there are few reports of pilomatricoma cases occurring after vaccination. A 21-month-old male patient was admitted to our clinic with a mass on his left arm that occurred after vaccination. The lesion was completely excised. The diagnosis of pilomatricoma was made after histopathological examination. As there were no predisposing factors other than vaccination, we concluded this to be a complication of the vaccination. The pathogenesis of pilomatricoma is unclear, but inflammation and trauma may promote neoplastic development. We report this case to draw attention to this rare lesion and to the possible etiopathogenetic association of vaccination with pilomatricoma.

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