Pilomatricoma (Malherbe)

Taaffe, A.; Wyatt, E.H.; Bury, Henry

doi:10.1111/j.1365-4362.1988.tb00924.x

Cited by 33 publications

(6 citation statements)

References 5 publications

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“…The age distribution of all our 22 patients demonstrates that pilomatricoma occurred in about 54.5% in children and young adults (below 30 years of age) and in about 45.5% in adults above 30 years of age (table 1). Our findings are quite similar to those of Kaddu et al [8]and also in accordance with those of Taaffe et al [12], who noted a second peak of onset in adults, too. Our observations show – by about 61.5% of all adult patients in the group of patients above 50 years of age – a noteworthy percentage of pilomatricomas (table 2).…”

Section: Discussionsupporting

confidence: 83%

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Pilomatricoma in Elderly Individuals

et al. 1998

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We report on 4 elderly patients aged 54–85 years with histopathologically diagnosed pilomatricoma who had been seen in our department from 1993 to 1997. Pilomatricoma is a rather uncommon neoplasm in middle-aged and old patients. It is much better known in children. Here, we clinically studied these 4 cases of pilomatricoma in elderly patients (above 50 years of age) to show the variety of clinical differential diagnosis and discuss the clinicopathological features. The results of the present study indicate that the differential diagnosis of pilomatricoma should also be considered in elderly individuals.

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Section: Discussionsupporting

confidence: 83%

“…Reports on the occurrence of pilomatricoma in the external ear canal have been published [13, 14]. The female-to-male ratio is roughly between 3:2 [4, 5, 7]and 1:1 [1, 3, 8, 12]. The malignant counterpart of pilomtricoma is very rare with a low tendency for metastasis [6, 15].…”

Section: Discussionmentioning

confidence: 99%

Pilomatricoma in Elderly Individuals

et al. 1998

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“…We think that pilomatricoma and matrical carcinoma should also be included in the list of differential diagnosis due to matrical differentiation of the cells composing these two neoplasms. Pilomatricoma differs histologically from TG in the presence of cystic changes and proliferation of matrical cells with rather dark chromatin that show transition to ‘shadow’ cells with subsequent calcification and ossification [4, 5, 6, 7]. The malignant counterpart of pilomatricoma – matrical carcinoma – is distinguished by its ‘malignant’ architecture with invasion and destruction of surrounding tissue and presence of atypical cells and high mitotic activity [8, 9].…”

Section: Discussionmentioning

confidence: 99%

Trichogerminoma: A Rare Cutaneous Adnexal Tumor with Differentiation toward the Hair Germ Epithelium

et al. 2002

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In 1992, Sau and colleagues described 14 cases of a rare cutaneous adnexal tumor with differentiation toward the hair germ epithelium. All cases in their study displayed a unique constellation of histological features which allowed the authors to consider the neoplasm to be a distinct entity and to designate it as ‘trichogerminoma’ (TG). We present a case of an adnexal tumor identical to that described as TG and report the immunophenotypical features of this neoplasm for the first time. A biopsy from a 41-year-old man revealed a well-demarcated epithelial tumor composed of multiple lobules located in the deep dermis without connection to the overlying epidermis and surrounded by a fibrous pseudocapsule. The tumorous lobules were composed of uniform basophilic cells with vesicular nuclei, dispersed chromatin and prominent nucleoli showing no prominent peripheral palisading. Some of the lobules had the appearance of densely packed ‘cell balls’ with peripheral condensation of the tumor cells. The stroma showed a moderate number of fibroblasts and mast cells. Reticulum staining revealed fine reticulum fibers surrounding the tumor aggregates with accentuation of the ‘cell balls’. Immunohistochemically, the tumor cells expressed AE1/AE3, CK5/8, CK5/6, CAM5.2 and stained negatively for CK20, CK7, calretinin, Lu-5 and Thomsen- Friedensreich antigen. There was no increase in the numbers of CK20-positive Merkel cells in the epidermis overlying the tumor; however, a few Merkel cells were scattered in some tumor lobules. In addition, we stained 6 trichoblastomas (TBs) and found a particular pattern of calretinin expression in this tumor which was not observed in our case of TG. We conclude that pathological features allow the delineation of TG as a distinct adnexal neoplasm. Histological differential diagnosis includes basal-cell carcinoma (pilar type), large nodular TB, trichoblastic fibroma, trichoepithelioma, tricholemmoma, pilomatricoma and matrical carcinoma.

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“…It is more common at a young age, especially in the first two decades of life, with an onset below 10 years in 40% of cases [4,5]. Although multiple localizations have been described in literature [6,7], PM occurs as a solitary lesion on the face (47% of cases), neck [8] and upper trunk and can be associated to other diseases, e.g. Steinert's Myotonic Dystrophy and Gardner Syndrome [4,7,9,10].…”

Section: Introductionmentioning

confidence: 99%

Epithelioma of Malherbe: new ultrasound patterns

Solivetti

Elia

Drusco

et al. 2010

J Exp Clin Cancer Res

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BackroundCalcifying epithelioma of Malherbe, or Pilomatricoma, is considered an uncommon cutaneous neoplasia, normally occurring in children as a solitary, firm, asymptomatic, hard, subcutaneous, slowly growing nodule on the face, neck, or proximal upper extremity. In literature, two Pilomatricoma ultrasound patterns are described: the totally calcified nodule and the hypoechoic nodule with internal calcific foci. High frequency ultrasound has not yet been applied for routine diagnosis of Pilomatricoma. The aim of the study was to retrospectively identify specific ultrasound features.MethodsWe retrieved 124 histologically Pilomatricoma cases: 28 patients with 32 lesions were preoperatively evaluated with ultrasound.Results22/32 have shown a solid formation, hypoechoic, with a sharp outline. Of these 22, 10 lesions were completely calcifying and 12 partially calcified. In 3/32 lesions with uncertain diagnosis, ultrasounds showed a complex/mixed pattern with pseudo-fluid areas and microspots. 7/32 lesions with US different diagnosis included 3 complex lesions, 2 cystic lesions and 2 solid nodular lesions.ConclusionIn addition to well-known ultrasound patterns (completely calcified and partially calcified) we identified three new, not yet described, patterns that constitute the 31% of the cases: complex, pseudocistyc and pseudotumoral.

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Pilomatricoma (Malherbe)

Cited by 33 publications

References 5 publications

Pilomatricoma in Elderly Individuals

Pilomatricoma in Elderly Individuals

Trichogerminoma: A Rare Cutaneous Adnexal Tumor with Differentiation toward the Hair Germ Epithelium

Epithelioma of Malherbe: new ultrasound patterns

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