Pilomatrixkarzinom in ungewöhnlicher Lokalisation

Abstract

A 58-year-old man developed an extensive pilomatrical carcinoma in the left axilla. Clinically, a squamous cell carcinoma was suspected. Histological examination revealed the presence of proliferating basaloid cells with many atypical mitoses and mass necrosis infiltrating into the subcutaneous tissue. The tumor was removed by micrographic surgery with a 2 cm safety margin. Histological examination of 2 regional lymph nodes as well as further diagnostic procedures ruled out metastases. We review the clinical and histopathological differences between pilomatricoma and pilomatrical carcinoma, as well as the published cases of the malignant variant.

Pilomatrix Carcinoma with Lymph Node and Pulmonary Metastases

“…PC generally occurs as an asymptomatic mass and lesions are mainly situated on the scalp, posterior area of the neck, buttocks, and upper extremities, although they have also been reported in other areas such as the axilla [7] and inguinal region [36]. Recurrences of PC are common, but metastasizing disease is exceedingly rare, with only twelve cases reported in the medical literature ( Table 1).…”

CASE REPORT Concurrent pilomatrix carcinoma and giant pilomatrixoma

“…In 1993, a series of 20 patients with pilomatrix carcinoma was reported and 23 other patients in the literature were reviewed 4 . There are a further 36 cases in the world literature 5,9–40 . It has been disputed whether these 79 reported cases are all true carcinomas and some may be benign pilomatrixomas with atypical histology or behaviour 6 .…”

Pilomatrixom

“…Pilomatrixkarzinome sind gekennzeichnet durch lokal aggressives Wachstum, erhöhte Neigung zu Lokalrezidiven und Metastasierungspotenz [2]. Als weitere klinische Unterscheidungskriterien gelten die unscharfe Abgrenzung zur Umgebung sowie Ulzerationen.…”

“…Schattenzellen, als große, polygonale, keratinisierte Zellen mit zentral liegenden, schemenhaft erkennbaren Kernumrissen, gestellt [2]. Die klinische Abgrenzung gegenüber Dermatofibromen, Spitz-Nävi oder amelanotischen Melanomen ist mitunter nicht sicher möglich.…”