Pilot Assessment of the Repeatability of Indocyanine Green Fluorescence Imaging and Correlation with Traditional Foot Perfusion Assessments

Venermo, Maarit; Settembre, Nicla; Albäck, Anders; Vikatmaa, Pirkka; Aho, Pekka; Lepäntalo, Mauri; Inoue, Yasuhiro; Terasaki, Hiroaki

doi:10.1016/j.ejvs.2016.06.018

Cited by 26 publications

(33 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are in accordance with previous findings of the present authors, as well as with results published by others. 17,19 The reproducibility of the IFA technique for the CLI patient was shown by Venermo et al 20 Previous studies had already confirmed this correlation with established non-invasive methods such as ABI, TBI, and TcPO 2 . 17, 19,20 However, the advantage of IFA is the topographical visualisation of the perfusion of the foot.…”

Section: Discussionmentioning

confidence: 84%

“…17,19 The reproducibility of the IFA technique for the CLI patient was shown by Venermo et al 20 Previous studies had already confirmed this correlation with established non-invasive methods such as ABI, TBI, and TcPO 2 . 17, 19,20 However, the advantage of IFA is the topographical visualisation of the perfusion of the foot. Thereby, different areas of the foot can be analysed separately, and comparison of the directly and indirectly revascularised angiosomes is possible.…”

Section: Discussionmentioning

confidence: 84%

See 1 more Smart Citation

Pilot Assessment of the Angiosome Concept by Intra-operative Fluorescence Angiography After Tibial Bypass Surgery

Rother

Lang

Horch

et al. 2018

European Journal of Vascular and Endovascular Surgery

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 84%

Pilot Assessment of the Angiosome Concept by Intra-operative Fluorescence Angiography After Tibial Bypass Surgery

Rother

Lang

Horch

et al. 2018

European Journal of Vascular and Endovascular Surgery

View full text Add to dashboard Cite

show abstract

“…ICG perfusion imaging in vascular surgery has been studied in a perfusion rat model to diagnose peripheral arterial occlusive disease. Perfusion rates of lower extremities with severe peripheral arterial occlusive disease was significantly lower than those of normal controls [55]. [57,58] demonstrated that ICG could rapidly target lipidrich atheroma in cholesterol-fed New Zealand white rabbits.…”

Section: Icg Imaging In Vascular Surgerymentioning

confidence: 99%

“…ICG fluorescence imaging in the assessment of critical limb ischemia is a recent method of imaging the foot perfusion. In a pilot study from Venermo et al[55], 41 patients with critical limb ischemia underwent ICG-fluorescence imaging after injecting ICG into the cephalic vein.ICG fluorescence imaging was quick to perform, easy to repeat due to rapid clearance of ICG and well tolerated. ICG fluorescence imaging in critical limb ischemia can be used to assess circulation at different sites, for example, at wound areas or the plantar side of the foot, which is not possible with transcutaneous oxygen pressure.…”

mentioning

confidence: 99%

Photodynamic therapy for atherosclerosis. The potential of indocyanine green

Houthoofd¹,

Vuylsteke

Mordon

et al. 2020

Photodiagnosis and Photodynamic Therapy

View full text Add to dashboard Cite

The aim of this article is to summarize and review the use of photodynamic therapy for the treatment of atherosclerotic plaque and the prevention of intimal hyperplasia. Different photosensitizers are discussed and more specific the role of indocyanine green as a potential photosensitizer. Methods: Literature search with focus on the use of photodynamic therapy in atherosclerosis, the mechanism of action and the different photosensitizers for photodynamic therapy. Results: In-vitro and in-vivo studies confirm the use of photodynamic therapy for the treatment of atherosclerosis and the prevention of restenosis. Non-specific accumulation of photosensitizer and thus phototoxicity, remains an important problem. Indocyanine green is a photosensitizer with features in favor of photodynamic therapy. The results of photodynamic therapy with indocyanine green point towards the potential of indocyanine green as a photosensitizer in photodynamic therapy for atherosclerosis. Conclusion: Photodynamic therapy is a promising tool for atherosclerosis. Many of the studied photosensitizers have toxic effects. Indocyanine green might be a good photosensitizer for the use of photodynamic therapy in atherosclerosis. These data justify further research to the use of indocyanine green as a photosensitizer in the treatment of atherosclerotic plaque both de novo or in restenotic lesions.

show abstract

“…Although some publications exist on the use of fluorescence imaging in the assessment of ischemic feet, the technique is uncommon in vascular surgery. Few studies are available on patients with peripheral arterial disease [6][7][8][9]. Terasaki et al [6] introduced the use of two parameters, PDE10 and T1/2 derived from the time-intensity curve, to be used in the assessment of foot perfusion.…”

Section: Introductionmentioning

confidence: 99%

Quality Control of the Foot Revascularization Using Indocyanine Green Fluorescence Imaging

et al. 2017

View full text Add to dashboard Cite

Objectives Critical limb ischemia (CLI) is a clinical diagnosis, confirmed by objective tests, usually ankle-brachial index (ABI), toe pressure (TP) and TcPO2. Furthermore, the anatomical lesions in patients affected by CLI were visualized by ultrasound, angiography, CTA, or MRA. Indocyanine green fluorescence imaging (ICG-FI) is a diagnostic modality for assessing foot perfusion. We aimed to study the usefulness of ICG-FI in the quality control of revascularization. Materials and methods One hundred and four CLI limbs in 101 patients were studied with ICG-FI using SPY Elite before and after open or endovascular revascularization. ABI and TP were also measured. After ICG-FI, assessment of circulation was done using time-intensity curve derived from the two regions of interest the one being in the plantar side of the foot and the other in the dorsal side of the foot. Three parameters were derived from the curves: maximum intensity (the absolute value of the maximum intensity); intensity rate (the value from the time-intensity curve describing the increase in maximum intensity/s) and SPY10 (the intensity achieved during the first 10 s after the foot starts to gain intensity). Results Sixty-two limbs presented category 3 of Rutherford classification, 12 limbs category 4, and 30 limbs category 5. Ninety-five technically successful procedures were achieved, 63 (66.3%) endovascular and 32 (33.7%) surgical revascularizations. In 9 (9.5%) patients, an in-line flow from the aorta to the foot was not achieved due to a failure to recanalize the occlusion (n = 7) or due to distal embolization (n = 2). ABI was not reliable in 58 patients (57.4%) mostly due to pseudohypertension and TPs in 49 (48.5%) patients mostly due to previous minor amputations. ICG-FI was successful in all patients. The mean intensity values before and after the procedure in patients who underwent successful revascularization were 81 ± 47 units and 120 ± 5 units of intensity (p \ .001) and intensity rates 4.2 ± 4 and 8.0 ± 6.2 units/s (p = .001), respectively. In the PTA patients in whom the revascularization was unsuccessful, no changes were seen in the hemodynamic parameters. In 6 (8.8%) patients who underwent technically successful revascularization, the SPY values were worse after the revascularization than at the baseline. Conclusions ICG-FI with SPY Elite provides reliable information on the increase in perfusion after revascularization, in addition to implicating possible failure if there is no improvement in the ICG-FI variables. Unlike ABI and TP, it can be performed in all patients. It gives valuable information to complement traditional assessment methods.

show abstract

Pilot Assessment of the Repeatability of Indocyanine Green Fluorescence Imaging and Correlation with Traditional Foot Perfusion Assessments

Cited by 26 publications

References 14 publications

Pilot Assessment of the Angiosome Concept by Intra-operative Fluorescence Angiography After Tibial Bypass Surgery

Pilot Assessment of the Angiosome Concept by Intra-operative Fluorescence Angiography After Tibial Bypass Surgery

Photodynamic therapy for atherosclerosis. The potential of indocyanine green

Quality Control of the Foot Revascularization Using Indocyanine Green Fluorescence Imaging

Contact Info

Product

Resources

About