Pilot Feasibility Study Examining Pupillary Response During Driving Simulation as a Measure of Cognitive Load in Breast Cancer Survivors

Myers, Jamie; Alissa, Nesreen; Mitchell, Melissa; Dai, Junqiang; He, Jia; Moon, Sanghee; O’Dea, Anne; Klemp, Jennifer R.; Kurylo, Monica; Akinwuntan, Abiodun Emmanuel; Devos, Hannes

doi:10.1188/20.onf.203-212

Cited by 4 publications

(5 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the ICA is claimed to be unaffected by changes in eye movements and sampling rate [ 27 ]. The ICA in particular has been used to investigate changes in cognitive workload in individuals at risk of cognitive impairment, including those with Parkinson’s disease, multiple sclerosis, and breast cancer [ 4 , 28 , 29 , 30 , 31 , 32 ]. Overall, the ICA seems to increase with cognitive demand, regardless of disease condition [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Psychometric Properties of NASA-TLX and Index of Cognitive Activity as Measures of Cognitive Workload in Older Adults

et al. 2020

Self Cite

View full text Add to dashboard Cite

Cognitive workload is increasingly recognized as an important determinant of performance in cognitive tests and daily life activities. Cognitive workload is a measure of physical and mental effort allocation to a task, which can be determined through self-report or physiological measures. However, the reliability and validity of these measures have not been established in older adults with a wide range of cognitive ability. The aim of this study was to establish the test–retest reliability of the National Aeronautics and Space Administration Task Load Index (NASA-TLX) and Index of Cognitive Activity (ICA), extracted from pupillary size. The convergent validity of these measures against event-related potentials (ERPs) was also investigated. A total of 38 individuals with scores on the Montreal Cognitive Assessment ranging between 17 and 30 completed a working memory test (n-back) with three levels of difficulty at baseline and at a two-week follow-up. The intraclass correlation coefficients (ICC) values of the NASA-TLX ranged between 0.71 and 0.81, demonstrating good to excellent reliability. The mean ICA scores showed fair to good reliability, with ICCs ranging between 0.56 and 0.73. The mean ICA and NASA-TLX scores showed significant and moderate correlations (Pearson’s r ranging between 0.30 and 0.33) with the third positive peak of the ERP at the midline channels. We conclude that ICA and NASA-TLX are reliable measures of cognitive workload in older adults. Further research is needed in dissecting the subjective and objective constructs of cognitive workload.

show abstract

Section: Introductionmentioning

confidence: 99%

Psychometric Properties of NASA-TLX and Index of Cognitive Activity as Measures of Cognitive Workload in Older Adults

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Here, we observe the RTA rate over a period of 7 years and report no difference in RTA risk between nine cancer groups and one control group. Compared to the earlier literature, [17][18][19][20]22 our study is the largest study with a control group focusing on cancer We were able to differentiate driver responsibility based on sex and birth year in the registry and could confirm that the study participant was most likely the at-fault driver. We also observed that among cancer patients, advanced stage at diagnosis, or use of anticancer treatment did not lead to an increased risk of RTA.…”

Section: Cancer Diagnosis Not Associated With An Increased Car Crash ...mentioning

confidence: 71%

“…Here, we observe the RTA rate over a period of 7 years and report no difference in RTA risk between nine cancer groups and one control group. Compared to the earlier literature, 17–20,22 our study is the largest study with a control group focusing on cancer patients. Around 200 annual RTA deaths are recorded in Finland, and fortunately, RTAs leading to injury were few, highlighting the need for large datasets and extensive follow‐up.…”

Section: Discussionmentioning

confidence: 98%

Section: Cancer Diagnosis Not Associated With An Increased Car Crash ...mentioning

confidence: 99%

“… 17 Another study from the United States showed that comorbid conditions, especially heart disease and stroke but not cancer, increased RTA risk in elderly patients. 18 Two small studies reported that patients with cancer fared worse in a virtual driving simulator, 19 , 20 but apart from these, no comparative traffic safety studies for cancer patients were found.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Controlled register‐based study of road traffic accidents in 12,651 Finnish cancer patients during 2013–2019

Huuskonen

Koistinen

Sihvola³

et al. 2022

Cancer Medicine

View full text Add to dashboard Cite

Background: Little controlled evidence exists on road traffic accident (RTA) risk among patients diagnosed with cancer, while clinicians are often requested to comment their ability to drive. The aim of this study was to evaluate RTA risk in a population-based cohort of cancer patients living in Southwest Finland.Patients: All adult patients diagnosed with cancer in 2013-2019 were included.Acute appendectomy/cholecystectomy and actinic keratosis patients without cancer were selected from the same region as the control cohort. Participants were cross-referenced to a national driving licence database, yielding 12,651 cancer and 6334 control patients with a valid licence. Due to marked differences in their clinical presentation, the cancer cohort was divided into nine cancers of interest (breast, prostate, colorectal, lung, melanoma, head & neck, primary brain tumours, gynaecological and haematological malignancies). The nationwide lawregulated motor liability insurance registry was searched for all RTAs leading to injury with claims paid to not-or at-fault participants. At-fault drivers were verified based on sex and birth year.Results: During a median follow-up of 34 months, 167 persons were at-fault drivers in RTAs leading to injury. Among the nine cancers of interest, RTA risk did not differ from the control cohort. Among cancer patients, multivariable regression suggested male sex and opioid use, but not advanced cancer stage or given systemic therapy, as the most influential risk factors for RTA.Conclusions: Cancer diagnosis itself was not associated with increased RTA risk, but other associated symptoms, medications, comorbidities or specific cancer subgroups may.

show abstract

Cognitive intra-individual variability in breast cancer survivors: A systematic review

Vance,

Collette,

Frank

et al. 2023

Applied Neuropsychology: Adult

View full text Add to dashboard Cite

Pilot Feasibility Study Examining Pupillary Response During Driving Simulation as a Measure of Cognitive Load in Breast Cancer Survivors

Abstract: OBJECTIVES:To test the feasibility of adding driving simulation tasks to measure visuospatial ability and processing speed to an existing neurocognitive battery for breast cancer survivors (BCSs).

Cited by 4 publications

References 37 publications

Psychometric Properties of NASA-TLX and Index of Cognitive Activity as Measures of Cognitive Workload in Older Adults

Psychometric Properties of NASA-TLX and Index of Cognitive Activity as Measures of Cognitive Workload in Older Adults

Controlled register‐based study of road traffic accidents in 12,651 Finnish cancer patients during 2013–2019

Cognitive intra-individual variability in breast cancer survivors: A systematic review

Contact Info

Product

Resources

About