Pilot-scale co-precipitation synthesis of a novel active ingredient made of ultrasmall iron (oxyhydr)oxide nanoparticles for the treatment of hyperphosphatemia

Abstract

Ultrasmall iron (oxyhydr)oxide nanoparticles can be prepared with a yield >40 g L−1 on a pilot scale by co-precipitation without losing their exceptionally high phosphate-binding efficacy. Only slight changes in composition were observed, attributed to a reduction in core size.