Pilot scale production of poly(3-hydroxybutyrate- co -4-hydroxybutyrate) biopolymers with high molecular weight and elastomeric properties

Huong, Kai‐Hee; Azuraini, Mat Junoh; Aziz, Nursolehah Abdul; Amirul, Al-Ashraf Abdullah

doi:10.1016/j.jbiosc.2017.02.003

Cited by 33 publications

(23 citation statements)

References 35 publications

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“…The scale-up strategy needs to be based on some criteria such as volumetric oxygen transfer coefficient ( k L a), volumetric power consumption (P/V), impeller tip speed (Vs) and mixing time (t m ) [ 22 , 23 , 24 ]. For aerobic fermentation, oxygen supply is one of the key limiting factors for microbial growth and product formation, thus volumetric oxygen transfer coefficient ( k L a) is generally used as a scale-up criterion [ 25 , 26 ]. k L a plays an important role in the design, scale-up and economy of the fermentation process.…”

Section: Introductionmentioning

confidence: 99%

Effects of Agitation, Aeration and Temperature on Production of a Novel Glycoprotein GP-1 by Streptomyces kanasenisi ZX01 and Scale-Up Based on Volumetric Oxygen Transfer Coefficient

et al. 2018

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The effects of temperature, agitation and aeration on glycoprotein GP-1 production by Streptomyces kanasenisi ZX01 in bench-scale fermentors were systematically investigated. The maximum final GP-1 production was achieved at an agitation speed of 200 rpm, aeration rate of 2.0 vvm and temperature of 30 °C. By using a dynamic gassing out method, the effects of agitation and aeration on volumetric oxygen transfer coefficient (kLa) were also studied. The values of volumetric oxygen transfer coefficient in the logarithmic phase increased with increase of agitation speed (from 14.53 to 32.82 h−1) and aeration rate (from 13.21 to 22.43 h−1). In addition, a successful scale-up from bench-scale to pilot-scale was performed based on volumetric oxygen transfer coefficient, resulting in final GP-1 production of 3.92, 4.03, 3.82 and 4.20 mg/L in 5 L, 15 L, 70 L and 500 L fermentors, respectively. These results indicated that constant volumetric oxygen transfer coefficient was appropriate for the scale-up of batch fermentation of glycoprotein GP-1 by Streptomyces kanasenisi ZX01, and this scale-up strategy successfully achieved 100-fold scale-up from bench-scale to pilot-scale fermentor.

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Section: Introductionmentioning

confidence: 99%

Effects of Agitation, Aeration and Temperature on Production of a Novel Glycoprotein GP-1 by Streptomyces kanasenisi ZX01 and Scale-Up Based on Volumetric Oxygen Transfer Coefficient

et al. 2018

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“…With the efforts on incorporating a 4‐hydroxybutyrate unit into P3HB, the obtained P(3HB‐ co ‐4HB) showed tunable hardness and flexibility via controlling the mole fraction of P4HB . Due to its variable physicochemical and mechanical properties, P3HB‐ co ‐P4HB is favored by researchers in many fields .…”

Section: Synthesis Of Polyhydroxyalkanoatesmentioning

confidence: 99%

Recent Progress in Polyhydroxyalkanoates‐Based Copolymers for Biomedical Applications

Luo

Liu

et al. 2019

Biotechnology Journal

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In recent years, naturally biodegradable polyhydroxyalkanoate (PHA) monopolymers have become focus of public attentions due to their good biocompatibility. However, due to its poor mechanical properties, high production costs, and limited functionality, its applications in materials, energy, and biomedical applications are greatly limited. In recent years, researchers have found that PHA copolymers have better thermal properties, mechanical processability, and physicochemical properties relative to their homopolymers. This review summarizes the synthesis of PHA copolymers by the latest biosynthetic and chemical modification methods. The modified PHA copolymer could greatly reduce the production cost with elevated mechanical or physicochemical properties, which can further meet the practical needs of various fields. This review further summarizes the broad applications of modified PHA copolymers in biomedical applications, which might shred lights on their commercial applications.

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“…Moreover, in biomedical industry based bioplastics has been named as the eyes of biomaterial because it is highly applicable in skins replacements for burnings and wounds, scaffolds for tissue engineering, bone reconstruction, nerves and gum reconstruction, drugs releasing system, blood vessel growth and stent covering [40,51,66]. Besides, in dental industry bioplastics based nanocellulose has been used in dental tissue regeneration in humans which is produced from microbial cellulose by the Glucanacetobacter xylinus strain [69].…”

Section: Applications Of Bioplasticsmentioning

confidence: 99%

Current Development on Bioplastics and Its Future Prospects: An Introductory Review

Sidek¹,

Draman²,

Abdullah³

et al. 2019

I. tech. mag.

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Bioplastics are kind of plastics produce from natural and renewable raw materials biomass sources such as sugarcane, corn starch, wood, waste paper, vegetable oils and fats, bacteria, algae, etc. Mostly, the commercial plastics in the marketplace are made from non-renewable petroleum based and this product can cause damaging to the ecosystem of the nature. Bioplastics are not harmful to nature environment because it can decompose back into carbon dioxide. Thus, the demand for applications of bioplastics are growing rapidly. The products made from bioplastics should be commercialize because they are renewable, biodegradable, compostable and environmentally friendly. The aims of this short review are to present about classifications of bioplastic, their advantages and disadvantages, processing, applications and challenges. Finally, the possible future developments of bioplastics are prospected.

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Pilot scale production of poly(3-hydroxybutyrate- co -4-hydroxybutyrate) biopolymers with high molecular weight and elastomeric properties

Cited by 33 publications

References 35 publications

Effects of Agitation, Aeration and Temperature on Production of a Novel Glycoprotein GP-1 by Streptomyces kanasenisi ZX01 and Scale-Up Based on Volumetric Oxygen Transfer Coefficient

Effects of Agitation, Aeration and Temperature on Production of a Novel Glycoprotein GP-1 by Streptomyces kanasenisi ZX01 and Scale-Up Based on Volumetric Oxygen Transfer Coefficient

Recent Progress in Polyhydroxyalkanoates‐Based Copolymers for Biomedical Applications

Current Development on Bioplastics and Its Future Prospects: An Introductory Review

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