Pilot study of a lifestyle intervention for bipolar disorder: Nutrition exercise wellness treatment (NEW Tx)

Sylvia, Louisa G.; Pegg, Samantha; Dufour, Steven; Janos, Jessica; Bernstein, Emily E.; Chang, Weilynn C.; Hall, Nathan; Ellard, Kristen K.; Nierenberg, Andrew A.; Deckersbach, Thilo

doi:10.1016/j.jad.2019.03.033

Cited by 28 publications

(41 citation statements)

References 14 publications

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“…While the findings in our paper do not support the relationship between all lifestyle factors modifying depressed mood over time, the combination of the cross-sectional and longitudinal data, considered alongside the findings of other recent studies, does support the use of multipronged lifestyle intervention as being an effective approach (as embryonic RCT data has revealed [40]). An example of a multi-pronged lifestyle intervention is shown in the recently published NEWTx pilot study, which examined the intervention of nutrition, exercise and wellness via general education modules in 38 people with bipolar disorder (19 vs 19; active programme vs waitlist; assessors were blinded) [41]. While the treatment group reported a range of beneficial effects on their wellbeing and symptoms, only improvements in general functioning were significantly greater in the NEWTx group than in the control group.…”

Section: Discussionmentioning

confidence: 99%

Multiple lifestyle factors and depressed mood: a cross-sectional and longitudinal analysis of the UK Biobank (N = 84,860)

Sarris

Thomson

Hargraves

et al. 2020

BMC Med

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Background There is now evolving data exploring the relationship between depression and various individual lifestyle factors such as diet, physical activity, sleep, alcohol intake, and tobacco smoking. While this data is compelling, there is a paucity of longitudinal research examining how multiple lifestyle factors relate to depressed mood, and how these relations may differ in individuals with major depressive disorder (MDD) and those without a depressive disorder, as ‘healthy controls’ (HC). Methods To this end, we assessed the relationships between 6 key lifestyle factors (measured via self-report) and depressed mood (measured via a relevant item from the Patient Health Questionnaire) in individuals with a history of or current MDD and healthy controls (HCs). Cross-sectional analyses were performed in the UK Biobank baseline sample, and longitudinal analyses were conducted in those who completed the Mental Health Follow-up. Results Cross-sectional analysis of 84,860 participants showed that in both MDD and HCs, physical activity, healthy diet, and optimal sleep duration were associated with less frequency of depressed mood (all p < 0.001; ORs 0.62 to 0.94), whereas screen time and also tobacco smoking were associated with higher frequency of depressed mood (both p < 0.0001; ORs 1.09 to 1.36). In the longitudinal analysis, the lifestyle factors which were protective of depressed mood in both MDD and HCs were optimal sleep duration (MDD OR = 1.10; p < 0.001, HC OR = 1.08; p < 0.001) and lower screen time (MDD OR = 0.71; p < 0.001, HC OR = 0.80; p < 0.001). There was also a significant interaction between healthy diet and MDD status (p = 0.024), while a better-quality diet was indicated to be protective of depressed mood in HCs (OR = 0.92; p = 0.045) but was not associated with depressed mood in the MDD sample. In a cross-sectional (OR = 0.91; p < 0.0001) analysis, higher frequency of alcohol consumption was surprisingly associated with reduced frequency of depressed mood in MDD, but not in HCs. Conclusions Our data suggest that several lifestyle factors are associated with depressed mood, and in particular, it calls into consideration habits involving increased screen time and a poor sleep and dietary pattern as being partly implicated in the germination or exacerbation of depressed mood.

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Section: Discussionmentioning

confidence: 99%

Multiple lifestyle factors and depressed mood: a cross-sectional and longitudinal analysis of the UK Biobank (N = 84,860)

Sarris

Thomson

Hargraves

et al. 2020

BMC Med

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“…Sylvia et al in their study compared two groups consisting of bipolar patients with conventional treatment plus exercise and special diet vs a single conventional group 10 . Accordingly, function improvement was significantly greater in the plus exercise and diet group, but no difference was found in mental status between these two groups as same as the amount of weight reduction and cardiac status.…”

Section: Discussionmentioning

confidence: 99%

“…10 Accordingly, function improvement was significantly greater in the plus exercise and diet group, but no difference was found in mental status between these two groups as same as the amount of weight reduction and cardiac status. However, this study has not considered other physical health status body weight of participants.…”

mentioning

confidence: 82%

Physical fitness in patients with bipolar disorder compared with a population‐based sample

Kheradmand

AbediYekta

Safarzadeh

et al. 2022

Health Science Reports

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Background This study aimed to evaluate physical fitness and body composition in a sample including hospitalized patients with bipolar disorder and to compare them with a population‐based sample. Methods In this comparative observational study, 40 bipolar patients and 40 healthy subjects in Taleghani Hospital, Tehran, Iran, in 2019 were assessed. The physical fitness items such as body mass index (BMI), body fat, push‐up test, curl‐up test, VO2 peak, and sit and reach test were compared across the groups. Young Mania Rating Scale for assessing the severity of bipolar disease and WHODAS2.0 for the estimation of global performance were done in the case group. Results The results of this study demonstrate that sit and reach test, body mass index (BMI), and body fat percent were similar across the studied groups. The push‐up test, curl‐up test, and VO2 peak (P = .001) were significantly lower in the case group. In the case group, only the push‐up test was associated with the severity of bipolar disorder and decreased performance. Conclusion Lower push‐up and curl‐up can indicate an increase in both back and neck pains in these patients. Low VO2 peak in these patients increases the risk of heart disease and mortality rates in bipolar patients. The push‐up test can be used as a screen test to estimate the severity of the bipolar disorder.

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“…When exercise was examined in a retrospective cohort study, it was found that exercise reduced depressive and anxious symptoms ( Ng et al., 2007 ). Another study examined exercise and healthy eating's contribution to BD depression symptoms; again, those patients who participated in the exercise and healthy eating group had a more significant improvement in depressive symptoms ( Sylvia et al., 2019 ). Finally, physical exercise has also been shown to positively impact the gut microbiota ( Monda et al., 2017 ) and thereby influence BBB properties, as discussed earlier.…”

Section: Potential Mechanisms Affecting the Bbb In Bdmentioning

confidence: 99%

Blood-brain barrier dysfunction in bipolar disorder: Molecular mechanisms and clinical implications

Zhao

Topolski

Tusconi

et al. 2022

Brain, Behavior, & Immunity - Health

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Pilot study of a lifestyle intervention for bipolar disorder: Nutrition exercise wellness treatment (NEW Tx)

Cited by 28 publications

References 14 publications

Multiple lifestyle factors and depressed mood: a cross-sectional and longitudinal analysis of the UK Biobank (N = 84,860)

Multiple lifestyle factors and depressed mood: a cross-sectional and longitudinal analysis of the UK Biobank (N = 84,860)

Physical fitness in patients with bipolar disorder compared with a population‐based sample

Blood-brain barrier dysfunction in bipolar disorder: Molecular mechanisms and clinical implications

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