Pilot Study of a New Mandibular Advancement Device

Abstract

This study was conducted to determine the efficacy of a customized mandibular advancement device (MAD) in the treatment of obstructive sleep apnea (OSA). Eight patients (M = 3; F = 5; mean age = 56.3 ± 9.4) with a diagnosis of OSA confirmed by polysomnography (PSG) were recruited on the basis of the following inclusion criteria: apnea-hypopnea index (AHI) > 5, age between 18 and 75 years, body mass index (BMI) < 25, and PSG data available at baseline (T0). All were treated with the new NOA® MAD by OrthoApnea (NOA®) for at least 3 months; PSG with NOA in situ was performed after 3 months of treatment (T1). The following parameters were calculated at T0 and T1: AHI, supine AHI, oxygen desaturation index (ODI), percentage of recording time spent with oxygen saturation <90% (SpO2 < 90%), and mean oxygen desaturation (MeanSpO2%). Data were submitted for statistical analysis. The baseline values were AHI = 21.33 ± 14.79, supine AHI = 35.64 ± 12.80, ODI = 17.51 ± 13.5, SpO2 < 90% = 7.82 ± 17.08, and MeanSpO2% = 93.45 ± 1.86. Four patients had mild OSA (5 > AHI < 15), one moderate OSA (15 > AHI < 30), and three severe OSA (AHI > 30). After treatment with NOA®, statistically significant improvements in AHI (8.6 ± 4.21) and supine AHI (11.21 ± 7.26) were recorded. OrthoApnea NOA® could be an effective alternative in the treatment of OSA: the device improved the PSG parameters assessed.

Mandibular Jaw Movement Automated Analysis for Oral Appliance Monitoring in Obstructive Sleep Apnea: A Prospective Cohort Study

“…However, MAD was not suitable for patients who exhibited severe sleepiness or for professional drivers and those with compromised stomatognathic situation (fewer than eight teeth per arch, temporomandibular disorder, periodontitis). The MAD used was a two-piece custom-made device (NOA; OrthoApnea) ( 19 ) ( see data supplement for further details).…”

A Scoping Review of Sleep Apnea: Where Do We Stand?

“…The prefabricated designs are also known as thermoplastic appliances, which are relatively cheaper and the kind that can be bought over the counter. On the other hand, custom-made designs are relatively more sophisticated and expensive because they are produced in a specialized dental laboratory and require the dental imaging of the patient to ensure a good fit [ 87 , 88 ]. While prefabricated devices are simple in design, custom-made designs are more intricate in nature and can consist of multiple and separate parts for the lower and upper jaw.…”

Patients with Obstructive Sleep Apnea and Cardiovascular Diseases: What, When, and Why Is Mandibular Advancement Device Treatment Required? A Short Review

“…Oral appliances (OA) protrude the mandible during sleep to maintain upper airway patency and include a titratable mechanism that allows for a gradual protrusion. Their principle is to increase and stabilize the oropharyngeal and hypopharyngeal airway space by repositioning and maintaining the lower jaw in a forward position during sleep [18,19].…”