Pilot study of combined aerobic and resistance exercise on fatigue for patients with head and neck cancer: Inflammatory and epigenetic changes

Xiao, Canhua; Beitler, Jonathan J.; Higgins, Kristin; Chico, Cynthia E; Withycombe, Janice S.; Zhu, Ying; Zhao, Hongyu; Lin, I‐Hsin; Li, Fangyong; Jeon, Sangchoon; Irwin, Melinda L.; Bruner, Deborah Watkins; Miller, Andrew H.; Gary, Rebecca

doi:10.1016/j.bbi.2020.04.044

Cited by 17 publications

(17 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yen et al [27] reported that an 8-week combined aerobic exercise and resistance exercise intervention significantly improved body composition and exercise responses in patients undergoing chemotherapy for HNC as compared with a sedentary group. Our results on HRQoL, in particular fatigue, are in line with previous studies in patients receiving radiotherapy for HNC [40,41]. Moreover, we also found significant differences in U/E and L/E flexibility and dynamic balance within the exercise group and between two groups, respectively.…”

Section: Discussionsupporting

confidence: 92%

“…The findings of greater improvements in body composition, muscle strength and HRQoL in the exercise group compared with the control group concur with the results from previous RCTs of combined aerobic and resistance exercise in patients with HNC undergoing concurrent chemoradiotherapy [22], chemotherapy [27] and radiotherapy [24,40]. In Zhao et al's research, patients undergoing concurrent chemoradiotherapy for HNC were randomized into a maintaining physical activity during cancer treatment (MPACT) group or a control group [22]; the study found a significant beneficial effect of knee strength, mental health and HRQoL in the MPACT group, who received a 14-week functional resistance and walking program, compared to the control group.…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Effects of Exercise in Patients Undergoing Chemotherapy for Head and Neck Cancer: A Pilot Randomized Controlled Trial

Lin

Cheng

Yen

et al. 2021

IJERPH

View full text Add to dashboard Cite

Background: Cisplatin administration may induce muscle atrophy, thereby reducing the fitness level of patients with head and neck cancer (HNC). To date, only animal studies have been conducted to test the effectiveness of exercise interventions in diminishing side effects of cisplatin. Aim: To determine whether exercise training improves physical fitness and health-related quality of life (HRQoL) in patients receiving chemotherapy for Head & Neck (H&N). Material and methods: This pilot-randomized controlled trial was conducted on 57 participants receiving chemotherapy for HNC. The participants were randomized into an exercise group and a control group. The exercise group received moderate-intensity combined aerobic, resistance and flexibility exercises three times a week for eight weeks during chemotherapy. The control group received no specific information regarding exercise. The outcome measures including body composition, muscle strength, balance, flexibility, cardiovascular fitness and health-related quality of life (HRQoL) were assessed at baseline and eight weeks following baseline. Results: The body composition (body fat percentage, p = 0.002; skeletal muscle percentage, p = 0.008), dynamic balance (p = 0.01), muscle strength (upper extremity, p = 0.037; lower extremity, p = 0.025) and HRQoL (p = 0.001) showed a significant difference between the exercise group and the control group eight weeks following baseline. Significant deteriorations were noted in flexibility, muscle strength, cardiovascular fitness and several domains of HRQoL scale in the control group at eight weeks following baseline. Conclusions: This study found that a combined aerobic, resistance and flexibility exercise program during chemotherapy may improve physical fitness (i.e., muscle strength, balance, flexibility and body composition) and HRQoL and alleviate the deterioration of cardiovascular fitness in patients with HNC. Further research studies with large sample sizes are warranted to investigate the long-term effects of exercise in this population.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 88%

Effects of Exercise in Patients Undergoing Chemotherapy for Head and Neck Cancer: A Pilot Randomized Controlled Trial

Lin

Cheng

Yen

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…[32][33][34] Pain is the most common complaint in 80% of the patients that is managed with pharmacological protocol involving NSAID's, opioids and steroids. [5,35] Besides movement restriction of neck, jaw and shoulder are managed with physical therapy that include utilisation of electrotherapeutic modalities, exercise protocols and manual techniques [12,[25][26][27][28][29][30][31][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] Manual therapy techniques when applied to shoulder and neck region have shown to be effective in improving outcome measures including pain and QOL suggesting their safety. Possible reason for safe utilisation of manual therapy approaches in cancer could be because of their principles based on soft tissue that reduces acute inflammation in response to exercise.…”

Section: Discussionmentioning

confidence: 99%

Role of Manual Therapy for Neck Pain and Quality of Life in Head and Neck Cancer Survivors: A Systematic Review

Pattanshetty

Patil

2021

IJPC

View full text Add to dashboard Cite

Background: Pain is the one the most dreadful side effects of head and neck cancers and cancer related treatments affecting patients during and after the treatment adding to the problems affecting their ability to speak, swallow, breath and feeding. Manual therapy is standard set of physiotherapy treatments used for alleviating neck pain. It has found to be effective in small subset of cancer patients for relieving pain. Objectives: To highlight the use of various manual therapy techniques focusing in decreasing neck pain and improving quality of life in Head and Neck Cancer survivors that may suggest its safe utilisation in oncology rehabilitation. Materials and Methods: Electronic search was conducted in PubMed, Google Scholar, CINAHL, Pedro, and COCHRANE databases. Reference lists of the included studies and relevant reviews were manually searched. Studies that met the inclusion criteria were evaluated using McMaster critical review form for quantitative studies. A descriptive synthesis was undertaken due to the heterogeneity of the included studies. Results: Seven studies were assessed for risk of bias that comprised of three clinical trials, one case series and three case reports that applied Maitland’s mobilisation, Myofascial release, Muscle Energy Techniques to head and neck cancer survivors in various clinical settings. The outcomes highlighted decrease in pain, improvement in cervical range of motion and quality of life. Conclusion: This review recommends application of manual therapy to head and neck cancer survivors. However, authors caution application of manual therapy in terms of choosing a particular technique. Further, well designed larger sample size with randomisation and double blinding would help to generate better evidence for head and neck cancer survivors.

show abstract

“…Increase in skeletal muscle and lean body mass [41][42][43][44] Improvement in fatigue and acute QoL symptom management.…”

Section: Reduced Exercise Resistance Trainingmentioning

confidence: 99%

“…Fatigue has also been demonstrated to have an impact on the patients’ social functioning, including their motivation for social interactions and personal care, including the desire to source and prepare nutritional meals, and their ability to earn an income [ 65 ]. Despite the certainty of this population experiencing fatigue, it has been demonstrated that exercise, particularly resistance exercise, can reduce the experience of fatigue in this population [ 41 , 42 ].…”

Section: Treatment-related Toxicitiesmentioning

confidence: 99%

Toxicities Caused by Head and Neck Cancer Treatments and Their Influence on the Development of Malnutrition: Review of the Literature

Hunter

Kellett

Toohey

et al. 2020

EJIHPE

View full text Add to dashboard Cite

Malnutrition poses a significant problem for oncology patients, resulting in fatalities within this population. Patients with head and neck cancer (HNC) are at high risk, with up to 90% developing malnutrition. Common treatments used for HNC can often lead to adverse side effects, including oral health conditions, gastrointestinal upsets, and several metabolic changes. Consequently, treatments can cause inadequate nutritional intake, resulting in a reduction in energy consumption, and alterations in energy utilization, contributing to the development of malnutrition. Furthermore, the presence of these treatment toxicities, and the related malnutrition can lead to reduced quality of life, weight loss, and psychological distress. There are interventions available (nutritional, medicinal, and physical therapies) that have demonstrated potential effectiveness in reducing the severity of symptomatic toxicities, reducing the risk of malnutrition, and improving survival outcomes of patients with HNC. Based on the findings of this review, there is an urgent need for the implementation or continuation of multi-disciplinary strategies, as well as updated and improved guidelines to assist in the prevention and treatment of malnutrition caused by treatment-related toxicities in patients with HNC.

show abstract

Pilot study of combined aerobic and resistance exercise on fatigue for patients with head and neck cancer: Inflammatory and epigenetic changes

Cited by 17 publications

References 74 publications

Effects of Exercise in Patients Undergoing Chemotherapy for Head and Neck Cancer: A Pilot Randomized Controlled Trial

Effects of Exercise in Patients Undergoing Chemotherapy for Head and Neck Cancer: A Pilot Randomized Controlled Trial

Role of Manual Therapy for Neck Pain and Quality of Life in Head and Neck Cancer Survivors: A Systematic Review

Toxicities Caused by Head and Neck Cancer Treatments and Their Influence on the Development of Malnutrition: Review of the Literature

Contact Info

Product

Resources

About