Pilot Study of Cystochon<sup>®</sup> (Cranberry Extract, Chondroitin Sulfate, and Hyaluronic Acid Complex) in Interstitial Cystitis/Bladder Pain Syndrome

Kim, Kwang Taek; Lee, Jeong Woo; Choe, Hyun‐Sop

doi:10.14777/uti.2022.17.2.36

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…Hence, research on effective treatment is highly required for IC. Recently, plant-based therapeutics have shown promising results against IC [ 16 , 35 ]. The anti-IC activity of shionone was studied in both in vitro and in vivo experiments.…”

Section: Pharmacological Activities Of Shiononementioning

confidence: 99%

Pharmacological Properties of Shionone: Potential Anti-Inflammatory Phytochemical against Different Diseases

Jaiswal,

Lee

2023

Molecules

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Shionone is a triterpenoid that is the primary constituent of an important ancient Chinese medicine named Radix Asteris. It has emerged as an attractive candidate against different important diseases, including interstitial cystitis, colitis, cancer, Parkinson’s disease, and urinary tract infections, and was found to have a protective effect on multiple organs, including the colon, kidneys, lungs, brain, and bladder. The anti-inflammation activity of shionone may be considered an important property that imparts the positive health outcomes of shionone. Important molecular targets and markers such as TNF-α, STAT3, NLRP3, and NF-κB were also found to be targeted by shionone and were verified in different diseases. This suggests the possible potential of shionone against other diseases associated with these targets. Pharmacokinetic studies also support the therapeutic potential of shionone and provide the initial track that may be pursued for its development. Yet, the compilation of the pharmacological activities of shionone and its important genes and pathway targets are absent in the existing literature, which would direct its development as a therapeutic and/or supplement. Hence, the present review provides a compilation of information concerning pharmacological activities, highlights the existing holes, and proposes a specific direction for the expansion of shionone as a therapeutic against different diseases and conditions.

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Section: Pharmacological Activities Of Shiononementioning

confidence: 99%

Pharmacological Properties of Shionone: Potential Anti-Inflammatory Phytochemical against Different Diseases

Jaiswal,

Lee

2023

Molecules

View full text Add to dashboard Cite

show abstract

Pilot Study of Cystochon^® (Cranberry Extract, Chondroitin Sulfate, and Hyaluronic Acid Complex) in Interstitial Cystitis/Bladder Pain Syndrome

Cited by 1 publication

References 14 publications

Pharmacological Properties of Shionone: Potential Anti-Inflammatory Phytochemical against Different Diseases

Pharmacological Properties of Shionone: Potential Anti-Inflammatory Phytochemical against Different Diseases

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Pilot Study of Cystochon® (Cranberry Extract, Chondroitin Sulfate, and Hyaluronic Acid Complex) in Interstitial Cystitis/Bladder Pain Syndrome

Cited by 1 publication

References 14 publications

Pharmacological Properties of Shionone: Potential Anti-Inflammatory Phytochemical against Different Diseases

Pharmacological Properties of Shionone: Potential Anti-Inflammatory Phytochemical against Different Diseases

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Product

Resources

About

Pilot Study of Cystochon^® (Cranberry Extract, Chondroitin Sulfate, and Hyaluronic Acid Complex) in Interstitial Cystitis/Bladder Pain Syndrome