Pilot study of the effect of therapeutic photobiomodulation on postoperative pain in knee arthroplasty

Rezende, Márcia Uchôa de; Varone, Bruno Butturi; Martuscelli, Diego Ferreira; Ocampos, Guilherme Pereira; Freire, George Miguel Góes; Pinto, Nathali Cordeiro; Sousa, Marcelo Victor Pires de

doi:10.1016/j.bjane.2021.07.040

“…The results are significantly heterogeneous ( I 2 = 97%) ( Figure 3 ). The increase in score was most pronounced in 1 month after DEB treatment and decreased gradually with the extended treatment time, but the difference in baseline level was statistically significant [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

“…The study compared the efficacy of DEB with DEB combined HA, and two studies compared the efficacy of DEB with glucocorticosteroids; 1 study compared the clinical effects of DEB with ozone. In terms of the severity of the classification of AKP, a total of 12 studies used the Kellgren-Lawrence scale, and 1 study used Ahlback scales; in addition, 1 study was not reported [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

Efficacy and Adverse Reactions of Arthroscopic Half-Moon Plate Invasive Surgery in Patients with Acute Knee Pain (AKP): Systematic Review and Meta-Analysis

Sun

¹

,

Huang²

2022

Applied Bionics and Biomechanics

1

0

1

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Objective. To evaluate the efficacy and adverse reactions of arthroscopic half-moon plate invasive surgery (DEB) in patients with knee pain (AKP) using meta-analysis techniques. Methods. The computer retrieves from the English databases PubMed, EMBASE, Cochrane Library, and Web of Science and the Chinese databases China Knowledge Network, Wanfang Database, VIP Database, and China Biomedical Literature Database to collect information about DEB therapeutic AKP randomized controlled trial. Develop criteria for documentation inclusion and exclusion, evaluate the quality and bias risk of literature, and compare differences in efficacy and adverse responses before and after DEB treatment and other conservative treatments. Results. A total of 14 randomized controlled trials and 1464 AKP patients were included in the study, with follow-up duration of 1-12 months. The total knee scores for DEB at 1, 3, 6, and 12 months after treatment were significantly better than baseline levels (1 month: WMD = 34.56 , P = 0.02 ; 3 months: WMD = 27.73 , P = 0.0001 ; 6 months: SMD = 2.38 , P = 0.0001 ; 12 months: SMD = 1.69 , P = 0.001 ). At 6 months of follow-up, DEB improved knee function better than HA ( SMD = 0.47 , P = 0.003 ), and during follow-up for 12 months, DEB relieved knee pain ( SMD = 0.55 , P = 0.0007 ) and improved knee function ( SMD = 0.88 , P = 0.0001 ) which is significantly better than HA. DEB was less effective at improving knee function in 1, 3, and 12 months than DEB joint HA injections (1 month P = 004 ; 3 months P = 0.01 ; 12 months P = 0.03 ). At 6 and 12 months of follow-up, DEB was better at pain relief and improved function than ozone ( P > 0.05 ). DEB and glucocorticosteroids have similar effects in pain relief and improved function at various follow-up times. In terms of adverse reactions, DEB does not increase the risk of adverse events compared to HA ( OR = 0.96 , P = 0.85 ). Conclusion. Compared to HA and ozone, DEB is a more effective treatment for AKP joints, while DEB is combined with HA. The clinical efficacy of injection therapy AKP is better than that of DEB alone.

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“…Two small pilot studies evaluated the feasibility of PBM for patients undergoing total knee arthroplasty. In the first study, de Rezende et al 39 reported administering PBM to 9 patients immediately following the surgery and 24 h later at the hospital. In the second study, Vassão and Laakso 40 reported a case series ( n = 4) of patients who applied light patches at home daily the week before surgery and every other day on the week after the surgery.…”

Section: Discussionmentioning

confidence: 99%

Photobiomodulation self‐treatment at home after rotator cuff arthroscopic repair accelerates improvement in pain, functionality, and quality of life: A double‐blind, sham‐controlled, randomized clinical trial

Abufoul,

Gavish,

Haddad

2023

Lasers Surg Med

3

0

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ObjectiveTo determine whether self‐applied photobiomodulation (PBM) therapy at home, following rotator cuff arthroscopic surgery (RCAS) can accelerate improvement in patient‐reported outcomes within the first 6 months postsurgery.MethodsThis study was a prospective, double‐blind, sham‐controlled, randomized clinical trial (NCT04593342). Patients (n = 50, age 55 ± 7 years, male:female 29:21) who underwent primary RCAS were randomized to receive active (n = 22) or sham (n = 28) PBM devices (B‐Cure Laser Pro, Erica B‐Cure LASER Ltd., Haifa, Israel) in addition to standard care. Patients self‐applied the treatments (808 nm, 15 min, 16.5 J/cm2) at home for 3 months postsurgery. Evaluations were conducted before the surgery (baseline) and at 1–3 and 6 months post‐RCAS (FU‐1M, FU‐3M, FU‐6M), and included Constant–Murley score (CMS), range of motion (ROM), subjective pain by visual analogue scale (VAS), disability by QuickDASH, and quality of life (QOL) by SF‐12. The difference from baseline to follow‐up (ΔFU), %patients achieving minimal clinical important difference (MCID), and patient acceptable symptom score (PASS) were calculated. Comparisons were conducted with superiority 2‐sample t test and χ2.ResultsBaseline values were not significantly different between groups. Both groups had similar improvements in CMS and ROM. However, compared to Sham, PBM significantly accelerated subjective pain reduction at 3 and 6 months (VAS mean ± SD, PBM‐vs‐Sham: ΔFU‐3M 32 ± 33 vs. 16 ± 27, p = 0.040; ΔFU‐6M: 41 ± 36 vs. 23 ± 26, p = 0.038), with a significantly higher proportion of patients achieving MCID at 3 months (76% vs. 48%, p = 0.027) and PASS at 6 months (48% vs. 23%, p = 0.044). PBM also significantly accelerated improvement in functionality and QOL at 6 months (QuickDASH ΔFU‐6M: 30 ± 24 vs. 18 ± 14, p = 0.029; SF‐12 physical component 6.8 ± 12.5 vs. 0.4 ± 8.6, p = 0.031; SF‐12 mental component 8.5 ± 9.1 vs. 2.2 ± 12, p = 0.032).ConclusionsSelf‐applied photobiomodulation following RCAS significantly accelerates decrease in pain and disability, and improves QOL. This nonpharmacologic add‐on therapeutic modality is easy to use and encourages active patient involvement. Its potential use in rehabilitation following other surgeries should be considered.Level of evidenceLevel I, high‐quality RCT.

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“…Developments made in the light of recent research have been in the direction of increasing fertility potential by irradiating sperm cells in the cryopreservation process in different spectrum areas (Fernandes et al 2015, Iaffaldano et al 2016, Yeste et al 2016. Additionally, light application (photobiomodulation) has areas of use in terms of phototherapy (Desan et al 2007, Saltmarche 2008, Avci et al 2013, Soares et al 2021, de Rezende et al 2022.…”

Section: Introductionmentioning

confidence: 99%

Polish Journal of Veterinary Sciences

Ömür

¹

2022

3

0

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The aim of this study was to determine the time-dependent effectiveness of photo-stimulation against bovine sperm cells using a multi-wavelength LED (Light Emitting Diode). Spermatological parameters were evaluated for viability, acrosome structure and motility. In addition, the effect of photo-stimulation on frozen-thawed sperm cells subjected to in vitro capacitation was evaluated in terms of changes in mitochondrial membrane potential. The study consisted of two separate experiments and a total of 32 sperm samples obtained from separate bulls were used. All sperm samples were obtained from Holstein bulls using an artificial vagina. Semen was diluted to a final concentration of 92 x 10 6 spermatozoa per ml in 0.25 ml straws. The sperm cells were frozen using the conventional method. Straws were kept in a 37°C water bath for 20 seconds and diluted 1:4 in phosphate buffered saline (PBS) to eliminate the potentially deleterious effect of glycerol, the main permeable cryoprotectant in the freezing medium for bull sperm. This dilution also helped in the evaluation of sperm quality parameters. In the first experiment, whereas the 15-10-15 showed no differences with the control, other treatments such as 10-10-10, 5-5-5, and 3-1-3 exhibited significantly higher percentages of viable spermatozoa at 24h. The results obtained for acrosome integrity were pretty much similar to those observed in the sperm viability assessment. In effect, while the treatment consisting of 15-10-15 had no positive effects, shorter treatments exerted a much more positive effect. The percentages of acrosome-intact spermatozoa in 2-1-2 and 1-1-1 were significantly higher than those obtained in the control. The significant differences in mitochondrial membrane potential were observed at 0, 2, 4 and 24h post-photo-stimulation in all treatments, except 15-10-15. The highest increase in the percentage of spermatozoa exhibiting high mitochondrial membrane potential was found in 10-10-10, 5-5-5 and 3-1-3 treatments. With regard to total and progressive motility, whereas 10-10-10 was the best regime, 5-5-5 and 3-1-3 treatments also had a positive effect. However, 15-10-15 appeared to have a stimulating effect upon progressive motility at 2h and 4h but later declined and showed no significant differences with regard to the control at 24h. In the second experiment, not immediately after thawing but after having been kept at room temperature for up to 24h, it was observed that there was no statistical difference in terms of viability, acrosome integrity and total/progressive motility between photostimulation and the control group. This indicates that photo-stimulation is less able to exert a beneficial effect when post-thawed sperm are not immediately stimulated. As a result it was determined that photo-stimulation at a pattern of 10-10-10, 5-5-5, 3-1-3 and, to a lesser extent 2-1-2, increases the resilience of frozen-thawed bull sperm when applied upon thawing.

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Pilot study of the effect of therapeutic photobiomodulation on postoperative pain in knee arthroplasty

Cited by 4 publications

References 5 publications

Efficacy and Adverse Reactions of Arthroscopic Half-Moon Plate Invasive Surgery in Patients with Acute Knee Pain (AKP): Systematic Review and Meta-Analysis

Efficacy and Adverse Reactions of Arthroscopic Half-Moon Plate Invasive Surgery in Patients with Acute Knee Pain (AKP): Systematic Review and Meta-Analysis

Photobiomodulation self‐treatment at home after rotator cuff arthroscopic repair accelerates improvement in pain, functionality, and quality of life: A double‐blind, sham‐controlled, randomized clinical trial

Polish Journal of Veterinary Sciences

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