Pilot study of the effect of EPA + DHA supplementation on the fatty acid profile of erythrocytes and breast milk of lactating women from Sonsón, Colombia

Valencia-Naranjo, Alejandra; Manjarres-Correa, Luz M.; Bermúdez-Cardona, Juliana

doi:10.1016/j.crfs.2022.04.008

Cited by 11 publications

(4 citation statements)

References 35 publications

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“…In this study, we observed that environmental factors had a marked impact on the HBM lipid composition. As reported in several epidemiological studies, ,,, including our recent study on Finnish cohort, our data in the current study also showed that the HBM lipid composition was affected by the age and BMI of the mothers, while maternal diet had comparatively weaker effect on the lipid composition, and education or smoking did not show significant associations. The variation of lipid composition of HBM has been attributed to cultural differences (including diet and other lifestyle factors) and genetic differences; however, most studies have investigated the associations on total lipid or lipid FA level only.…”

Section: Resultssupporting

confidence: 89%

Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases

Hyötyläinen,

Ghaffarzadegan,

Karthikeyan

et al. 2024

Environ. Sci. Technol.

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The composition of human breast milk (HBM) exhibits significant variability both between individuals and within the same individual. While environmental factors are believed to play a role in this variation, their influence on breast milk composition remains inadequately understood. Herein, we investigate the impact of environmental factors on HBM lipid composition in a general population cohort. The study included mothers (All Babies In Southeast Sweden study) whose children later progressed to one or more immune-mediated diseases later in life: type 1 diabetes (n = 9), celiac disease (n = 24), juvenile idiopathic arthritis (n = 9), inflammatory bowel disease (n = 7), hypothyroidism (n = 6), and matched controls (n = 173). Lipidome of HBM was characterized by liquid chromatography combined with high-resolution mass spectrometry. We observed that maternal age, body mass index, diet, and exposure to perfluorinated alkyl substances (PFASs) had a marked impact on breast milk lipidome, with larger changes observed in the milk of those mothers whose children later developed autoimmune diseases. We also observed differences in breast milk lipid composition in those mothers whose offspring later developed autoimmune diseases. Our study suggests that breast milk lipid composition is modified by a complex interaction between genetic and environmental factors, and, importantly, this impact was significantly more pronounced in those mothers whose offspring later developed autoimmune/ inflammatory diseases. Our findings also suggest that merely assessing PFAS concentration may not capture the full extent of the impact of chemical exposures; thus, the more comprehensive exposome approach is essential for accurately assessing the impact of PFAS exposure on HBM and, consequently, on the health outcomes of the offspring.

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Section: Resultssupporting

confidence: 89%

Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases

Hyötyläinen,

Ghaffarzadegan,

Karthikeyan

et al. 2024

Environ. Sci. Technol.

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“…In fact, several studies on DHM in North America found DHA values that were similar to or even lower than those of our Veg group [116,117,123]. Secondly, since DHA supplementation to lactating women has consistently been shown to increase DHA concentrations in breast milk [124][125][126][127][128][129][130], it seems an appropriate strategy to recommend DHA supplementation from algal oil to Veg women who want to become milk donors. Most studies show that vegetarians, and especially vegans, consume low to zero amounts of EPA and DHA unless they take supplements [131].…”

Section: Discussionsupporting

confidence: 48%

Human Milk Composition and Nutritional Status of Omnivore Human Milk Donors Compared with Vegetarian/Vegan Lactating Mothers

et al. 2023

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Women of childbearing age in Western societies are increasingly adopting vegetarian diets. These women are sometimes rejected as milk donors, but little about the composition of their milk is known. The present study aimed to compare the intake, nutritional status, and nutritional composition of human milk from omnivore human milk donors (Donors) and vegetarian/vegan lactating mothers (Veg). Milk, blood, and urine samples from 92 Donors and 20 Veg were used to determine their fatty acid profiles, as well as vitamins and minerals. In a representative sample of both groups, we also determined the lipid class profile as a distribution of neutral and polar lipids, the molecular species of triacylglycerols, and the relative composition of phospholipids in their milk. A dietary assessment was conducted with a five-day dietary record (while considering the intake of supplements). We highlight the following results, expressed as the mean (SE), for the Veg vs. Donors: (1) Their docosahexaenoic acid (DHA) intake was 0.11 (0.03) vs. 0.38 (0.03) g/day; the plasma DHA was 0.37 (0.07) vs. 0.83 (0.06)%; and the milk DHA was 0.15 (0.04) vs. 0.33 (0.02)%. (2) Their milk B12 levels were 545.69 (20.49) vs. 482.89 (4.11) pM; 85% of the Veg reported taking B12 supplements (mean dose: 312.1 mcg/day); and the Veg group showed no differences with Donors in terms of total daily intake or plasma B12. (3) Their milk phosphatidylcholine levels were 26.88 (0.67) vs. 30.55 (1.10)%. (4) Their milk iodine levels were 126.42 (13.37) vs. 159.22 (5.13) mcg/L. In conclusion, the Vegs’ milk was shown to be different from the Donors’ milk, mainly due to its low DHA content, which is concerning. However, raising awareness and ensuring proper supplementation could bridge this gap, as has already been achieved for cobalamin.

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“…Nuestros resultados son consistentes con estudios recientes desarrollados en mujeres lactantes antioqueñas (33,34), los cuales reportaron altas prevalencias de deficiencia en el consumo de nutrientes como proteína, ácidos grasos esenciales, ácido fólico, vitaminas A y C, zinc y calcio, resultados similares a los encontrados en nuestro estudio. En el contexto latinoamericano, una investigación realizada en 50 mujeres chilenas sanas entre 20 y 33 años por Barrera et al (35), comparó la ingesta del sexto mes de embarazo con el sexto mes de lactancia, y se observó una reducción en la ingesta de los grupos de alimentos más nutritivos y un elevado consumo de los grupos de riesgo.…”

Section: Discussionunclassified

Evaluación de ingesta dietética en un grupo de mujeres lactantes en dos poblaciones de Antioquia, Colombia, 2021-2022

Arias-Gutiérrez,

Londoño-Sierra,

Correa-Guzmán

et al. 2023

Rev. colomb. obstet. ginecol.

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Objetivos: describir la prevalencia del riesgo de deficiencia o exceso en la ingesta de nutrientes y el patrón de consumo de alimentos de acuerdo con las recomendaciones establecidas por el Ministerio de Salud y Protección Social y el Instituto Colombianode Bienestar Familiar. Materiales y métodos: se realizó un estudio transversal descriptivo en mujeres sanas que fueron atendidas en dos hospitales del oriente antoqueño, con seguridad alimentaria y nutricional (SAN) según la Escala Latinoamericana y Caribeña de Seguridad Alimentaria (ELCSA), en el primer trimestre de lactancia, evaluadas entre los años 2021 y 2022. La fuente de información fue la historia clínica. Se midieron las características sociodemográficas, clínicas, antropométricas y la ingesta dietética y de micronutrientes. Se empleó estadística descriptiva. Se presenta la prevalencia de déficit o exceso de ingesta calórica y el índice de relación de consumo (IRC). Se utilizaron los software EVINDI v5, PCSIDE v1.0, Stata 16.1 y Jasp 0.16.4. Resultados: se incluyeron 30 mujeres lactantes. La prevalencia de riesgo de deficiencia en la ingesta usual de energía fue 43 % y exceso 16 %; el riesgo de deficiencia proteica fue 98 %. El consumo superior al valor de referencia para grasa saturada fue 86 % y carbohidratos simples 72 %. El patrón de consumo se caracterizó por superar las recomendaciones para azúcares (IRC = 1,29), leche y derivados (IRC = 1,09), cereales, raíces, plátanos y tubérculos (IRC = 1,04). No cumplieron las recomendaciones en la ingesta de grasas (IRC = 0,70), carnes, huevos, leguminosas, frutos secos y semillas (IRC = 0,49), frutas y verduras (IRC = 0,41). Conclusiones: el patrón alimentario identificado dista de las guías nacionales, lo que limita el consumo de macro y micronutrientes, y contribuye al círculo intergeneracional de la malnutrición. Es fundamental realizar nuevas investigaciones en el país para identificar otros patrones de consumo e impulsar acciones de política al respecto.

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Pilot study of the effect of EPA + DHA supplementation on the fatty acid profile of erythrocytes and breast milk of lactating women from Sonsón, Colombia

Cited by 11 publications

References 35 publications

Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases

Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases

Human Milk Composition and Nutritional Status of Omnivore Human Milk Donors Compared with Vegetarian/Vegan Lactating Mothers

Evaluación de ingesta dietética en un grupo de mujeres lactantes en dos poblaciones de Antioquia, Colombia, 2021-2022

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