Pilot Study on Childhood Sexual Abuse, Diurnal Cortisol Secretion, and Weight Loss in Bariatric Surgery Patients

Hulme, Polly A.; McBride, Corrigan L.; Kupzyk, Kevin; French, Jeffrey A.

doi:10.1080/10538712.2015.1022293

Cited by 10 publications

(4 citation statements)

References 50 publications

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“…However, the two groups did not differ in weight loss or waist circumference (117). By contrast, Hulme et al found that BS did not affect daily cortisol secretion patterns during the first 6 months after surgery, although morning cortisol showed a slightly non-significant post-operative increase (122).…”

Section: Non-metabolic Bs-induced Endocrine Alterationsmentioning

confidence: 88%

Metabolic and Endocrine Consequences of Bariatric Surgery

2019

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Obesity is one of the most serious worldwide epidemics of the twenty-first century according to the World Health Organization. Frequently associated with a number of comorbidities, obesity threatens and compromises individual health and quality of life. Bariatric surgery (BS) has been demonstrated to be an effective treatment to achieve not only sustained weight loss but also significant metabolic improvement that goes beyond mere weight loss. The beneficial effects of BS on metabolic traits are so widely recognized that some authors have proposed BS as metabolic surgery that could be prescribed even for moderate obesity. However, most of the BS procedures imply malabsorption and/or gastric acid reduction which lead to nutrient deficiency and, consequently, further complications could be developed in the long term. In fact, BS not only affects metabolic homeostasis but also has pronounced effects on endocrine systems other than those exclusively involved in metabolic function. The somatotropic, corticotropic, and gonadal axes as well as bone health have also been shown to be affected by the various BS procedures. Accordingly, further consequences and complications of BS in the long term in systems other than metabolic system need to be addressed in large cohorts, taking into account each bariatric procedure before making generalized recommendations for BS. In this review, current data regarding these issues are summarized, paying special attention to the somatotropic, corticotropic, gonadal axes, and bone post-operative health.

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Section: Non-metabolic Bs-induced Endocrine Alterationsmentioning

confidence: 88%

Metabolic and Endocrine Consequences of Bariatric Surgery

2019

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“…Finally, a pilot study suggests that altered cortisol secretion in individuals who suffered from CSA is a contributing factor to the risk of adult obesity ( Hulme et al, 2015 ). Elevated glucocorticoid hormones in the CSA population might favor excess eating behaviors and negatively affect weight loss.…”

Section: Resultsmentioning

confidence: 99%

Psychobiological Consequences of Childhood Sexual Abuse: Current Knowledge and Clinical Implications

2021

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A large body of research has documented the long-term harms of childhood sexual abuse (CSA) on an individual’s emotional-adaptive function and mental health. Recent studies have also provided evidence of the biological impact of CSA, implicating specific alterations in many systems, including the endocrine and immune systems, and in DNA and chromatin, in the pathogenesis of medical disorders. Although the effects of CSA are often examined with regard to the general impact of early-life traumatic experiences, the study of CSA per sè, as a trigger of specific pathogenic pathways, would be more appropriate to understand their long-term implications and develop tailored diagnostic and therapeutic strategies. Based on these premises, this narrative minireview summarizes the research on the short-term and long-term sequelae of CSA, focusing on dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, the effects on the immune system, and the changes to DNA through altered methylation. Also, we discuss the literature that examines dysfunctional DNA telomere erosion and oxidative stress markers as a sign of CSA. Finally, recent evidence of the intergenerational transmission of the effects of CSA is reported. The impact of CSA on brain connectivity and functions is out of the scope of this review, thus brain imaging studies are not included. The results of this minireview are discussed, considering their implications for prevention and clinical practice.

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“…Exploration of the potential impact of childhood trauma on post-operative outcomes, including long-term weight outcome, may also be useful for informing the necessity and timing of interventions.Prior literature on the impact of a history of childhood trauma on subsequent weight loss has been limited and the results mixed. Although one pilot study found that childhood sexual abuse was associated with greater weight loss (29), other research found no association between adverse childhood experiences as post-surgery weightloss (30), and yet other investigations suggest poorer weight losses (31,32). Prospective studies are needed to examine the effects of childhood trauma and interventions to help bariatric surgery patients with a history of abuse and neglect achieve optimal health and wellbeing.…”

Section: Discussionmentioning

confidence: 99%

The relationship between childhood maltreatment and psychopathology in adults undergoing bariatric surgery

Orcutt

King

Kalarchian

et al. 2019

Surgery for Obesity and Related Diseases

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Background: History of childhood maltreatment and psychopathology are common in adults with obesity. Objectives: To report childhood maltreatment and to evaluate associations between severity and type of childhood maltreatment and lifetime history of psychopathology among adults with severe obesity awaiting bariatric surgery. Setting: Four clinical centers of the Longitudinal Assessment of Bariatric Surgery (LABS) Research Consortium. Methods: The Childhood Trauma Questionnaire, which assesses presence/severity (i.e., none, mild, moderate, severe) of physical abuse, mental abuse, physical neglect, mental neglect and sexual abuse, was completed by 302 female and 66 male bariatric surgery patients. Pre-surgery lifetime history of psychopathology and suicidal ideation/behavior (SI/B) were assessed with the

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Pilot Study on Childhood Sexual Abuse, Diurnal Cortisol Secretion, and Weight Loss in Bariatric Surgery Patients

Cited by 10 publications

References 50 publications

Metabolic and Endocrine Consequences of Bariatric Surgery

Metabolic and Endocrine Consequences of Bariatric Surgery

Psychobiological Consequences of Childhood Sexual Abuse: Current Knowledge and Clinical Implications

The relationship between childhood maltreatment and psychopathology in adults undergoing bariatric surgery

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