Pilot Study on the Effect of Orally Administered Bisphenol A on Glucose and Insulin Response in Nonobese Adults

Abstract

Objective To determine the effects of varying doses of orally administered BPA on indices of glucose metabolism. Methods Eleven college students (21.0 ± 0.8 years; 24.2 ± 3.9 kg/m2) were randomized in a double-blinded, crossover fashion separated by >1 week to placebo (PL), deuterated BPA at 4 µg/kg body weight (BPA-4), and deuterated BPA at 50 µg/kg body weight (BPA-50). Total BPA, glucose, insulin, and C-peptide were assessed at baseline, minutes 15, 30, 45, 60, and every 30 minutes for 2 hours in response to a glucose tolerance test. Results There was a significant condition × time interaction for total BPA (P < 0.001) such that BPA increased more rapidly in BPA-50 than BPA-4 and PL (P = 0.003) and increased more rapidly in BPA-4 than PL (P < 0.001). There were no significant condition × time interactions on glucose, insulin, and C-peptide. Significant condition main effects were observed for glucose such that BPA-50 was significantly lower than PL (P = 0.036) and nearly lower for BPA-4 vs PL (P = 0.056). Significant condition main effects were observed such that insulin in BPA-50 was lower than BPA-4 (P = 0.021), and C-peptide in BPA-50 was lower than BPA-4 (t18 = 3.95; Tukey-adjusted P = 0.003). Glucose, insulin, and C-peptide areas under the curve for the 3-hour profile were significantly lower in BPA-50 vs PL (P < 0.05). Conclusion Orally administered BPA protocol appeared feasible and has immediate effects on glucose, insulin, and C-peptide concentrations.

Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway

“…The rapid BPA-induced potentiation of GSIS has been demonstrated in primary mouse and human β-cells (Soriano et al, 2012). In addition, oral BPA administration rapidly altered insulin and Cpeptide levels in blood of adult individuals (Stahlhut et al, 2018;Hagobian et al, 2019). As in the present work BPS and BPF act akin to BPA in β-cells, an analogous effect on human cells might be expected.…”

Exposure to a “safe” dose of environmental pollutant bisphenol A elevates oxidative stress and modulates vasoactive system in hypertensive rats

“…8 Moreover, orally administered BPA at the US EPA-approved safe dose of 50 μg/kg has immediate effects on indices of glucose metabolism in young, non-obese adults. 9 At the mechanistic level, DNA damaging and apoptotic potentials of BPA and BPS in human bronchial epithelial cells indicate that BPA's DNA damaging potential is mediated through an ATM/ATR/Chk1/p53-dependent pathway. 10 Further, a recent exploration shows chronic exposure to BPA impairs carbohydrate and lipid metabolism by altering corresponding enzymatic and metabolic pathways.…”

Environmental neglect: endocrine disruptors as underappreciated but potentially modifiable diabetes risk factors

“…Collectively, these issues mandate rigorously designed epidemiological and animal studies. Importantly, recent clinical studies have demonstrated that administering BPA to humans alters glucose-insulin homeostasis [127,128]. While these data validate the robust cell-based, animal and epidemiological evidence linking BPA to metabolic disruptions, they also raise an important ethical question: Will such direct evidence of harm be required for each of the thousands of chemicals to which humans are exposed before action is taken to protect public health?…”