Pilot study on the identification of silver in skin layers and urine after dermal exposure to a functionalized textile

Bianco, Carlotta; Kežić, Sanja; Visser, Maaike; Pluut, Olivier A.; Adami, Gianpiero; Krystek, Petra

doi:10.1016/j.talanta.2014.12.043

Cited by 14 publications

(5 citation statements)

References 23 publications

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“…a) Time dependent cellular uptake of 75 nm Ag NPs by total quantification with HR-ICPMS The analytical method applied for the total quantification of Ag in cells was developed based on own experience of the quantification of noble metal nanoparticles in biological matrices [23]. The use of aqua regia as digestion media for nanosilver is more advantageous in comparison to nitric acid since in biological matrices also silver chloride (AgCl) is formed which is not dissoluble in nitric acid but which will be dissolved in aqua regia by forming a complex of silver di chloride (AgCl 2 ) − [24]. The measurement method was optimized and the settings are given in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Exploring influences on the cellular uptake of medium-sized silver nanoparticles into THP-1 cells

Krystek

Kettler

Wagt³

et al. 2015

Microchemical Journal

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Section: Resultsmentioning

confidence: 99%

Exploring influences on the cellular uptake of medium-sized silver nanoparticles into THP-1 cells

Krystek

Kettler

Wagt³

et al. 2015

Microchemical Journal

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“…Thus, ionization of silver nanoparticles and ability of Ag + ions to penetrate into or across the skin may result in nanotoxicity. Clinical trials have started, but their scope in limited (Bianco et al, 2015b;Munger et al, 2014;Rigo et al, 2013) In conclusion, this study found that 5 nm Ag nanoparticles cannot pass through rat skin, even after disruption of the epidermal barrier. In contrast, Ag + ions were able to penetrate rat skin after epidermal barrier disruption.…”

Section: Discussionmentioning

confidence: 73%

Permeability of skin to silver nanoparticles after epidermal skin barrier disruption in rats

Kuwagata

Kumagai

Saito

et al. 2017

Fundam. Toxicol. Sci.

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-To analyze the permeability of rat skin to silver nanoparticles, the dorsal skin of Sprague-Dawley rats was exposed to 5 nm Ag nanoparticles or silver nitrate (Ag + ions) percutaneously for 24 hr after disruption of the epidermal barrier by tape stripping (TS) or acetone wiping (AC). Systemic toxicity was examined hematologically and histopathologically, and by assessing blood biochemistry. Although parakeratosis, decrease in keratohyaline granule, and thickening in the epidermis occurred following exposure to both 5 nm Ag nanoparticles and Ag + ions after TS or AC, no Ag-specific changes were observed. Inductively coupled plasma mass spectrometry (ICP-MS) showed silver in the skin of rats exposed to both 5 nm Ag nanoparticles and Ag + ions after TS or AC. Silver was only detected in the liver of rats exposed to Ag + ions after TS, but not exposed to 5 nm Ag nanoparticles after TS or AC. No abnormal histopathological changes in the liver were observed in all rats. In the blood, silver was below detectable levels in all rats and had no adverse effects on hematology or blood biochemistry. These results indicate that silver ions released from 5 nm Ag nanoparticles can percutaneously infiltrate the body only when the skin barrier is disrupted, but does not induce any acute toxicity.

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“…Field trials and other research, which were carried out during NanoRem, have been incorporated into a risk screening model (Nathanail, Gillett, Mccaffrey, Nathanail, & Ogden, ). The risk model for NP applications considers the macro‐scale transport of NPs within saturated media and is based on a modified advection‐dispersion equation (Bianco et al., ; Tosco et al., ). The methodology depends on calculating values of attachment ( k att ) and detachment ( k det ) using the MNMs model (micro‐and NP transport, filtration, and clogging model suite).…”

Section: Risk‐benefit Appraisal For Nanorem Technologiesmentioning

confidence: 99%

“…Field trials and other research, which were carried out during NanoRem, have been incorporated into a risk screening model (Nathanail, Gillett, Mccaffrey, Nathanail, & Ogden, 2016). The risk model for NP applications considers the macro-scale transport of NPs within saturated media and is based on a modified advectiondispersion equation (Bianco et al, 2015;Tosco et al, 2016). The Regarding environmental impact of reactive NPs, toxicity testing of NanoRem NPs generally found that toxicity was low; typically the limiting concentration was 100 milligrams per liter.…”

Section: Environmental Risks From Deploymentmentioning

confidence: 99%

Status of nanoremediation and its potential for future deployment: Risk‐benefit and benchmarking appraisals

Bardos¹,

Merly²,

Kvapil

et al. 2018

Remediation Journal

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NanoRem (Taking Nanotechnological Remediation Processes from Lab Scale to End User Applications for the Restoration of a Clean Environment) was a research project, funded through the European Commission's Seventh Framework Programme, which focuses on facilitating practical, safe, economic, and exploitable nanotechnology for in situ remediation of polluted soil and groundwater, which closed in January 2017. This article describes the status of the nanoremediation implementation and future opportunities for deployment based on risk‐benefit appraisal and benchmarking undertaken in the NanoRem Project. As of November 2016, NanoRem identified 100 deployments of nanoremediation in the field. While the majority of these are pilot‐scale deployments, there are a number of large scale deployments over the last five to 10 years. Most applications have been for plume control (i.e., pathway management in groundwater), but a number of source control measures appear to have taken place. Nanoremediation has been most frequently applied to problems of chlorinated solvents and metals (such as chromium VI). The perception of risk‐benefit balance for nanoremediation has shifted as the NanoRem Project has proceeded. Niche benefits are now more strongly recognized, and some (if not most) of the concerns, for example, relating to environmental risks of nanoremediation deployment, prevalent when the project was proposed and initiated, have been addressed. Indeed, these now appear overstated. However, it appears to remain the case that in some jurisdictions the use of nanoparticles remains less attractive owing to regulatory concerns and/or a lack of awareness, meaning that regulators may demand additional verification measures compared to technologies with which they have a greater level of comfort.

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Pilot study on the identification of silver in skin layers and urine after dermal exposure to a functionalized textile

Cited by 14 publications

References 23 publications

Exploring influences on the cellular uptake of medium-sized silver nanoparticles into THP-1 cells

Exploring influences on the cellular uptake of medium-sized silver nanoparticles into THP-1 cells

Permeability of skin to silver nanoparticles after epidermal skin barrier disruption in rats

Status of nanoremediation and its potential for future deployment: Risk‐benefit and benchmarking appraisals

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