Unprecedented numbers of Americans experienced homelessness in 2023. Homelessness causes premature mortality from several preventable causes. Historically, research in homelessness has been driven by psychiatric and social science fields and has focused on neither health behavior nor valid measurement of health outcomes. Only in HIV/AIDS populations is there specific evidence linking housing with improved health outcomes. A partnership between behavioral medicine researchers and housing and homeless service providers could address health behaviors linked to premature mortality. This requires improving measurement of homeless mortality and validating health and wellness measures for people experiencing homelessness. We outline implications for policy to pair support for health behavior change in the context of homelessness with various housing support programs. When done with attention to multi-level health drivers and inclusion of people with lived experience, this partnership could improve health outcomes and reduce premature mortality for people without housing.