Pilot Validation of a New Wireless Patch System as an Ambulatory, Noninvasive Tool That Measures Gut Myoelectrical Signals: Physiologic and Disease Correlations

Axelrod, Lindsay; Axelrod, Steve; Navalgund, Anand; Triadafilopoulos, George

doi:10.1007/s10620-020-06663-y

Cited by 10 publications

(7 citation statements)

References 21 publications

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“…Another major difference is that the stomach normally has a single dominant pacemaker, but the colon has multiple independent and simultaneously active regions. While others have reported a colonic frequency range measured on the body surface of 12–20 cpm 50 , 51 , we have only observed frequencies up to a maximum of about 12 cpm from HRCM analysis, which is in keeping with the majority of manometry studies 31 , 33 , 34 , 52 . Also, our data clearly show that the observed frequency range from the body surface is not always directly congruent with actual colonic frequency range (due to summation effects), yet it still remains below 12 cpm.…”

Section: Discussionsupporting

confidence: 90%

Validation of body surface colonic mapping (BSCM) against high resolution colonic manometry for evaluation of colonic motility

Seo,

Wells,

Dickson

et al. 2024

Sci Rep

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Abnormal cyclic motor pattern (CMP) activity is implicated in colonic dysfunction, but the only tool to evaluate CMP activity, high-resolution colonic manometry (HRCM), remains expensive and not widely accessible. This study aimed to validate body surface colonic mapping (BSCM) through direct correlation with HRCM. Synchronous meal-test recordings were performed in asymptomatic participants with intact colons. A signal processing method for BSCM was developed to detect CMPs. Quantitative temporal analysis was performed comparing the meal responses and motility indices (MI). Spatial heat maps were also compared. Post-study questionnaires evaluated participants’ preference and comfort/distress experienced from either test. 11 participants were recruited and 7 had successful synchronous recordings (5 females/2 males; median age: 50 years [range 38–63]). The best-correlating MI temporal analyses achieved a high degree of agreement (median Pearson correlation coefficient (Rp) value: 0.69; range 0.47–0.77). HRCM and BSCM meal response start and end times (Rp = 0.998 and 0.83; both p < 0.05) and durations (Rp = 0.85; p = 0.03) were similar. Heat maps demonstrated good spatial agreement. BSCM is the first non-invasive method to be validated by demonstrating a direct spatio-temporal correlation to manometry in evaluating colonic motility.

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Section: Discussionsupporting

confidence: 90%

Validation of body surface colonic mapping (BSCM) against high resolution colonic manometry for evaluation of colonic motility

Seo,

Wells,

Dickson

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Another major difference is that the stomach normally has a single dominant pacemaker, but the colon has multiple independent and simultaneously active regions. While others have reported a colonic frequency range measured on the body surface of 12 to 20 cpm 50,51 , we have only observed frequencies up to a maximum of about 12 cpm from HRCM analysis, which is in keeping with the large majority of manometry studies 31,33,34,52 . Also, our data clearly show that the observed frequency range from the body surface is not always directly congruent with actual colonic frequency range (due to summation effects), yet it still remains below 12 cpm.…”

Section: Discussionsupporting

confidence: 89%

Validation of body surface colonic mapping against high resolution colonic manometry: a novel non-invasive tool for evaluation of colonic motility

Seo,

Wells,

Dickson

et al. 2023

Preprint

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Abnormal cyclic motor pattern (CMP) activity is implicated in colonic dysfunction, but the only tool to evaluate CMP activity, high-resolution colonic manometry (HRCM), remains expensive and not widely accessible. This study aimed to validate body surface colonic mapping (BSCM) through direct correlation with HRCM. Synchronous meal-test recordings were performed in asymptomatic participants with intact colons. A signal processing method for BSCM was developed to detect CMPs. Quantitative temporal analysis was performed comparing the meal responses and motility indices (MI). Spatial heat maps were also compared. Post-study questionnaire evaluated participants’ preference and comfort/distress experienced from either test. 11 participants were recruited and 7 had successful synchronous recordings (5 females/2 males; median age: 50 years [range: 38-63]). The best-correlating MI temporal analyses achieved a high degree of agreement (median Pearson correlation coefficient (Rp) value: 0.69; range: 0.47 - 0.77). HRCM and BSCM meal response start and end times (Rp= 0.998 and 0.83; bothp <0.05) and durations (Rp= 0.85;p= 0.03) were similar. Heat maps demonstrated good spatial agreement. BSCM is the first non-invasive method to be validated by demonstrating a direct spatio-temporal correlation to manometry in evaluating colonic motility.

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“…Furthermore, repeatability of sEEnG measurements has not been determined appropriately before. In 2020, Axelrod et al demonstrated that the dominant frequency and signal intensity of sEEnG were constant over a period of three years, but they only demonstrated this graphically [ 20 ]. The results of the current study provide new insights in the use of ultrasound to guide sEEnG electrode positioning as well as the repeatability of the sEEnG measurements.…”

Section: Discussionmentioning

confidence: 99%

Feasibility and repeatability of ultrasound-guided surface electroenterography to measure colonic slow wave motility in healthy adults

Rolleman,

Visser,

Klein

et al. 2024

BMC Gastroenterol

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Surface electroenterography is a potential non-invasive alternative to current diagnostics of colonic motility disorders. However, electrode positioning in electroenterography is often based on general anatomy and may lack generalizability. Furthermore, the repeatability of electroenterography measurements is unknown. This study aimed to evaluate ultrasound-guided electrode positioning for electroenterography measurements and to determine the repeatability of those measurements. In ten healthy adults, two electroenterography procedures were performed, consisting of fasting, ultrasound-guided electrode localization and two 20-minute electroenterography recordings separated by a meal. The dominant frequency, the mean power density (magnitude of colonic motility) and the power percent difference (relative pre- to postprandial increase in magnitude) were determined. Repeatability was determined by Lin’s concordance correlation coefficient. The results demonstrated that the dominant frequency did not differ between pre- and postprandial recordings and was 3 cpm, characteristic of colonic motility. The mean power density increased between the pre- and postprandial measurements, with an average difference of over 200%. The repeatability of both the dominant frequency and power density was poor to moderate, whereas the correlation coefficient of the power percent difference was poor. Concluding, ultrasound-guided surface electroenterography seems able to measure the gastrocolic reflex, but the dissatisfactory repeatability necessitates optimization of the measurement protocol.

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Pilot Validation of a New Wireless Patch System as an Ambulatory, Noninvasive Tool That Measures Gut Myoelectrical Signals: Physiologic and Disease Correlations

Cited by 10 publications

References 21 publications

Validation of body surface colonic mapping (BSCM) against high resolution colonic manometry for evaluation of colonic motility

Validation of body surface colonic mapping (BSCM) against high resolution colonic manometry for evaluation of colonic motility

Validation of body surface colonic mapping against high resolution colonic manometry: a novel non-invasive tool for evaluation of colonic motility

Feasibility and repeatability of ultrasound-guided surface electroenterography to measure colonic slow wave motility in healthy adults

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