Pilzerkrankungen des Auges

Abstract

Mycotic infections of the eye continue to be an important cause of ocular morbidity. Etiological factors and symptoms are useful for the diagnosis of fungal infections. Mycotic keratitis may be seen after trauma with vegetable material, or in previously diseased eyes. The most common pathogens are Candida, Fusarium, Aspergillus. Clinical features, like the pyramidal Hypopyon, can differentiate fungal from bacterial infections. Mycotic Endophthalmitis refers to intraocular inflammation caused by Candida, Aspergillus, and Cryptococcus. Exogenous mycotic endophthalmitis follows intraocular surgery or trauma. Endogenous mycotic endophthalmitis is frequently an ocular manifestation of a systemic disease. Early diagnosis should be made to ensure prompt initiation of antifungal therapy, to prevent visual loss.

CD3ε of a pan T cell marker involved in mouse Aspergillus fumigatus keratitis

“…In agriculture-based developing countries, plant-induced corneal damage is the main risk factor for FK [17] . Fungal infections of the eye can cause corneal edema, opacity, ulcers and even perforations, which can lead to decreased vision and even blindness [18][19] . The CD3 present on the surface of T cells is a characteristic sign of mature T cells, transducing the activation signal generated by TCR recognition antigen [20] .…”