Pimecrolimus in an adhesive ointment as a new treatment option for oral lichen planus

Dissemond, Joachim; Schröter, Stefan; Franckson, Tom; Herbig, S.; Goos, M.

doi:10.1111/j.0007-0963.2004.05884.x

Cited by 39 publications

(40 citation statements)

References 11 publications

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“…During the study period, reports were published regarding the efficacy of the topical calcineurin inhibitors tacrolimus [19][20][21] and, in oral disease, pimecrolimus, 22,23 and thus some women with resistant disease in this cohort started treatment. Two women with severe disease responded well to treatment, 1 with complete clearance of erosions after 10 years of active disease, but the response was less favorable in 5 others.…”

Section: Commentmentioning

confidence: 99%

Influence of Treatment of Erosive Lichen Planus of the Vulva on Its Prognosis

Cooper¹,

Wojnarowska²

2006

Arch Dermatol

142

131

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Section: Commentmentioning

confidence: 99%

Influence of Treatment of Erosive Lichen Planus of the Vulva on Its Prognosis

Cooper¹,

Wojnarowska²

2006

Arch Dermatol

142

131

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“…The involvement of mucous membranes is generally seen. In spite of generally without symptom, the disease is sometimes complicated by wide painful erosions, causing a significant loss of quality of life (7). Whether OLP has a premalignant potential is a matter of discussion.…”

Section: Discussionmentioning

confidence: 99%

“…There are some case reports and studies about use of pimecrolimus in OLP with successful results (7,8). A small series of three patients with OLP that is unresponsive to (17) reported a randomized placebocontrolled trial for pimecrolimus in the treatment of erosive OLP cases with a sample size of 12 (6 pimecrolimus, 6 placebo).…”

Section: Discussionmentioning

confidence: 99%

“…Unlike cutaneous lesions, especially erosive OLP is extremely resistant to topical treatment and tends to pursue a chronic process with little tendency to spontaneous resolution (1,7). OLP is a persistent problem, such that most often the best one can achieve is an amelioration of symptoms until resolution occurs.…”

Section: Introductionmentioning

confidence: 99%

“…Pimecrolimus binds to macrophilin-12 and thereby limits the calcium linked phosphatase calcineurin. By blocking the transcription of early cytokines and in this way downregulating synthesis of both T-helper 1-and 2-type cytokines, pimecrolimus inhibits T-cell activation in vitro (6,7,(11)(12)(13). The purpose of this study was to evaluate the efficacy, relative safety, and tolerability of 1% pimecrolimus cream in the treatment of OLP.…”

Section: Introductionmentioning

confidence: 99%

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The Effectiveness of Topical Pimecrolimus in the Treatment of Oral Lichen Planus

Mülayim¹,

Öztürk²,

Uzun³

2016

tdd

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Objectives: Oral lichen planus (OLP) is a chronic inflammatory disorder of unknown etiology that affects the skin and the mucosa, especially the oral mucosa. Several therapeutic agents have been investigated for the treatment of OLP. All agents used in the OLP therapy are palliative. Potent topical steroids are used as the conventional therapy for OLP. Since side-effects or steroid resistance may be encountered, alternative treatments may be necessary. This study aimed to evaluate the efficacy and safety of the topical pimecrolimus in the treatment of OLP. Methods: Seventeen patients with OLP were recruited into this study. Topical pimecrolimus 1% cream was applied twice a day to the affected areas. Patients were followed up for 3-6 months. Photographs of the lesions were taken and analyzed for areas of ulceration, erythema, and reticulation in every clinical examination. Results: We found that topical pimecrolimus 1% cream was an effective treatment for OLP. Two patients could not complete the treatment protocol because of the side effects such as local irritation and nausea. Conclusion: Topical pimecrolimus may be a valuable second treatment choice for patients with steroid-related side-effects or steroid-resistant OLP. However further randomized controlled studies have to be conducted to compare conventional treatment of topical corticosteroid with topical pimecrolimus. Keywords: Oral lichen planus, pimecrolimus, calcineurin inhibitor, treatment, efficacy, safety Öz Abstract Amaç: Oral liken planus (OLP) deri ve mukozaları özellikle de oral mukozayı tutan, etiyolojisi bilinmeyen kronik enflamatuvar bir hastalıktır. OLP tedavisi için birkaç terapötik ajan araştırılmıştır. OLP'nin tedavisinde kullanılan bütün ajanlar palyatif etkilidir. OLP'nin geleneksel tedavisinde potent topikal steroidler kullanılır. Steroidlerin yan etkileri veya steroide direnç ile karşılaşılabileceğinden alternatif tedaviler gerekli olabilir. Bu çalışmada topikal pimekrolimusun OLP'nin tedavisindeki etkinliğini ve güvenirliğini değerlendirmek amaçlandı. Yöntemler: OLP'li 17 hasta çalışmaya alındı. Topikal pimekrolimus %1 krem etkilenmiş bölgelere günde 2 kez uygulandı. Hastalar 3-6 ay süreyle aylık olarak takip edildi. Her kontrolde lezyonların fotoğrafı çekilerek ülserasyon, eritem ve ağ yapısı gibi özellikleri değerlendirildi. Bulgular: Biz OLP'nin tedavisinde topikal %1 pimekrolimusu etkili bulduk. Çalışmaya alınan iki hasta bulantı hissi ve lokal irritasyon gibi yan etkiler nedeni ile tedavi protokolünü tamamlayamadı. Sonuç: Topikal pimekrolimus, steroid ile ilişkili yan etkileri olan hastalarda veya steroide dirençli OLP'nin tedavisinde ikinci seçenek olarak düşünülebilir. Ancak etkinliği tam olarak değerlendirebilmek için OLP'nin geleneksel tedavisi olan topikal steroid ile topikal pimekrolimusun karşılaştırmalı, randomize, kontrollü çalışmaları yapılmalıdır.

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