Pimobendan, etilefrine, moxifloxacin, and esketamine as reference compounds to validate the DSI Physiotel Digital System in cynomolgus monkeys

Niehoff, Marc; Sternberg, J.; Niggemann, Birgit; Sarazan, Dusty

doi:10.1016/j.vascn.2014.03.102

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…ECG acquisition in NHP is complicated by the fact that conventional ECG electrodes require shaved skin and that awake animals do not easily tolerate skin-attachments unless extensively trained to do so. Hence, ECG in NHPs is either collected from sedated animals [ 6 , 8 , 9 ] or by implanting a telemetry device in combination with highly invasive intracorporal sensors [ 10 – 12 ]. For a non-invasive ECG acquisition from non-sedated monkeys a wearable jacket can be used [ 1 , 13 , 14 ], but this also requires extensive training and physical contact when preparing the animal, which may affect the physiological state.…”

Section: Introductionmentioning

confidence: 99%

Using imaging photoplethysmography for heart rate estimation in non-human primates

et al. 2018

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For humans and for non-human primates heart rate is a reliable indicator of an individual’s current physiological state, with applications ranging from health checks to experimental studies of cognitive and emotional state. In humans, changes in the optical properties of the skin tissue correlated with cardiac cycles (imaging photoplethysmogram, iPPG) allow non-contact estimation of heart rate by its proxy, pulse rate. Yet, there is no established simple and non-invasive technique for pulse rate measurements in awake and behaving animals. Using iPPG, we here demonstrate that pulse rate in rhesus monkeys can be accurately estimated from facial videos. We computed iPPGs from eight color facial videos of four awake head-stabilized rhesus monkeys. Pulse rate estimated from iPPGs was in good agreement with reference data from a contact pulse-oximeter: the error of pulse rate estimation was below 5% of the individual average pulse rate in 83% of the epochs; the error was below 10% for 98% of the epochs. We conclude that iPPG allows non-invasive and non-contact estimation of pulse rate in non-human primates, which is useful for physiological studies and can be used toward welfare-assessment of non-human primates in research.

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Section: Introductionmentioning

confidence: 99%

Using imaging photoplethysmography for heart rate estimation in non-human primates

et al. 2018

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“…Currently, implantable telemetry is considered the gold standard for large animal blood pressure measurement [168]. Various toxicology and pharmacology studies have been completed using implantable pressure telemetry [209][210][211].…”

Section: Direct Measurement Methodsmentioning

confidence: 99%

Miniature implantable telemetry system for pressure-volume cardiac monitoring

Fricke

Sobot

2013

2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)

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“…ECG acquisition in NHP is complicated by the fact that conventional ECG electrodes require shaved skin and that awake animals do not easily tolerate skin-attachments unless extensively trained to do so. Hence, ECG in NHPs is either collected from sedated animals [6,8,9] or by implanting a telemetry device in combination with highly invasive intracorporal sensors [10][11][12]. For a non-invasive ECG acquisition from non-sedated monkeys a wearable jacket can be used [1,13,14], but this also requires extensive training and physical contact when preparing the animal, which may affect the physiological state.…”

Section: Introductionmentioning

confidence: 99%

Using imaging photoplethysmography for heart rate estimation in non-human primates

Unakafov

Moeller

Kagan

et al. 2018

Preprint

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For humans and for non-human primates heart rate is a reliable indicator of an individual's current physiological state, with applications ranging from health checks to experimental studies of cognitive and emotional state. In humans, changes in the optical properties of the skin tissue correlated with cardiac cycles (imaging photoplethysmogram, iPPG) allow non-contact estimation of heart rate by its proxy, pulse rate. Yet, there is no established simple and non-invasive technique for pulse rate measurements in awake and behaving animals. Using iPPG, we here demonstrate that pulse rate in rhesus monkeys can be accurately estimated from facial videos. We computed iPPGs from seven color facial videos of three awake head-stabilized rhesus monkeys. Pulse rate estimated from iPPGs was in good agreement with reference data from a pulse-oximeter with error of pulse rate estimation below 5% for 82% of all epochs, and below 10% for 98% of the epochs. We conclude that iPPG allows non-invasive and non-contact estimation of pulse rate in non-human primates, which is useful for physiological studies and can be used toward welfare-assessment of non-human primates in research.

show abstract

Pimobendan, etilefrine, moxifloxacin, and esketamine as reference compounds to validate the DSI Physiotel Digital System in cynomolgus monkeys

Cited by 4 publications

References 3 publications

Using imaging photoplethysmography for heart rate estimation in non-human primates

Using imaging photoplethysmography for heart rate estimation in non-human primates

Miniature implantable telemetry system for pressure-volume cardiac monitoring

Using imaging photoplethysmography for heart rate estimation in non-human primates

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