Pimozide Therapy for Trigeminal Neuralgia

Lechín, Fuad; Dijs, Bertha van der; Lechin, Marcel E.; Amat, José; Lechin, Alex E.; Cabrera, Alejandra; Gómez, Francisca; Acosta, Emilio; Arocha, Luis; Villa, Simón; Jiménez, Vladimir

doi:10.1001/archneur.1989.00520450030015

Cited by 162 publications

(74 citation statements)

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“…101 In a randomized, controlled study of 30 patients with painful diabetic neuropathy, Rull et al 102 observed that after 14 days of treatment, as many as 50% more patients improved on carbamazepine.…”

Section: Carbamazepinementioning

confidence: 99%

Use of Antiepileptic Drugs for Nonepileptic Conditions: Psychiatric Disorders and Chronic Pain

2007

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Summary: Antiepileptic drugs (AEDs) are commonly utilized for nonepileptic conditions, including various psychiatric disorders and pain syndromes. Evidence for their benefit in these nonepileptic conditions varies widely among different drugs, but there is, in general, a paucity of published multicenter randomized double-blind trials. Variable levels of evidence suggest that lamotrigine and the vagal nerve stimulator have antidepressant properties. Carbamazepine, valproate, lamotrigine, and oxcarbazepine appear to have mood stabilizing properties while gabapentin, pregabalin, and tiagabine have anxiolytic benefits. Barbiturates, topiramate, and possibly phenytoin may precipitate or exacerbate depression. Underlying depression and anxiety symptoms may be exacerbated by levetiracetam, while psychotic symptoms have rarely been reported with topiramate, levetiracetam, and zonisamide. Pregabalin, gabapentin, carbamazepine, and oxcarbazepine have been used to treat neuropathic pain such as postherpetic neuralgia, and diabetic polyneuropathy. Topiramate and divalproex sodium have utility in the prophylaxis or acute treatment of migraine. Further rigorous studies are needed to clarify the utility of AEDs in nonepileptic conditions.

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Section: Carbamazepinementioning

confidence: 99%

Use of Antiepileptic Drugs for Nonepileptic Conditions: Psychiatric Disorders and Chronic Pain

2007

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“…Além disso, os resultados da avaliação do alívio global da dor foram ausência de alívio e alívio moderado para o dextrometafano, e alívio moderado e pouco alívio para o placebo, respectivamente para cada paciente, havendo um abandono por exacerbação da dor com o uso desta droga 42 . Três estudos controlados por tratamento ativo compararam a carbamazepina com a tizanidina 43 , a tocainida 44 e a pimozida 45 . A carbamazepina produziu melhores resultados do que a tizanidina, porém ocorreram dois abandonos por dor intolerável (apud Wiffen e col. 46 ).…”

Section: Resultsunclassified

“…Quarenta de 48 (83,3%) pacientes apresentaram efeitos adversos com a pimozida (incluindo lentidão física e mental, tremor nas mãos e manifestações semelhantes à doença de Parkinson) versus 21 dos 48 pacientes com a carbamazepina, não havendo abandono por efeitos adversos. Foram encontrados sérios efeitos tóxicos com a carbamazepina relacionados a elementos celulares do sangue (1), anormalidades na função hepática (1), desenvolvimento insidioso de lentidão física e mental (18) e secreção inadequada de vasopressina (1) 45 .…”

Section: Efeitos Adversos E Abandonos Dos Estudosunclassified

“…In addition, results of global pain relief evaluation were lack of relief or moderate relief for dextromethorphan, and moderate relief and poor relief for placebo, respectively for each patient, with one dropout by pain exacerbation with this drug 42 . Three controlled studies by active treatment have compared carbamazepine to tizanidine 43 , tocainide 44 and pimozide 45 . Carbamazepine has produced better results as compared to tizanidine, however there have been two dropouts by intolerable pain (apud Wiffen et al 46 ).…”

Section: Level Of Analgesiamentioning

confidence: 99%

“…Pimozide has promoted adverse effects in 40 out of 48 patients (including physical and mental slowness, hand shivering and Parkinson's disease-like manifestations) versus 21 out of 48 patients treated with carbamazepine, without dropouts by adverse events. Severe toxic effects were found with carbamazepine and were related to blood cell elements (1), liver function abnormalities (1), insidious development of physical and mental slowness (18) and inadequate vasopressin secretion (1) 45 .…”

Section: Level Of Analgesiamentioning

confidence: 99%

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Tratamento famacológico da neuralgia do trigêmeo: revisão sistemática e metanálise

Alves¹,

Azevedo²,

Carvalho³

2004

Rev. Bras. Anestesiol.

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RESUMO (Colaboração Cochrane, 2003). (Cochrane Collaboration, 2003). RESULTADOS: Os resultados da metanálise sugerem que a carbamazepina é mais eficaz que o placebo. Em três estudos controlados comparando a lamotrigina, o topiramato e o cloridrato de proparacaína ao placebo, somente a lamotrigina mostrou-se superior a ele. O dextrometafano foi comparado ao lorazepam em baixas doses, havendo aumento da dor com o u s o d a q u e l e f á r m a c o . Tr ê s e s t u d o s c o m pa r a r a m a carbamazepina com a tizanidina, a tocainida e a pimozida U n i t e r m o s : D O R , C r ô n i c a : n e u r a l g i a d o t r i g ê m e o ; TERAPÊUTICA, Farmacológica SUMMARY RESULTS: Metanalisys results suggest that carbamazepine is more efficient than placebo. In three controlled studies comparing lamotrigine, topiramate and 0.5% proparacaine hydrochlor i d e , o n l y l a m o t r i g i n e wa s s u p e r i o r t o p l a c e b o . Dextromethorphan was compared to low-dose lorazepam

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